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Volume 46, Issue 1

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Official Journal of the American Aging Association (AGE)

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Volume 46, Issue 1

February 2024

Special Issue: Understanding Senescence in Brain Aging and Alzheimer’s Disease and Special Issue: White matter lesions in age-related cognitive decline: etiology, risk factors, prevention and repair

Issue Editors:

Darren Baker,
Anna Csiszar,
Zoltan Ungvari,
JULIE ANDERSEN,
Farzaneh Sorond

89 articles in this issue

Brain age prediction across the human lifespan using multimodal MRI data
Sihai Guan
Runzhou Jiang
Bharat Biswal
ORIGINAL ARTICLE 21 September 2023 Pages: 1 - 20
Preventing spontaneous cerebral microhemorrhages in aging mice: a novel approach targeting cellular senescence with ABT263/navitoclax
Janet Faakye
Ádám Nyúl-Tóth
Zoltan Ungvari
ORIGINAL ARTICLE 04 December 2023 Pages: 21 - 37
Insights into ageing rates comparison across tissues from recalibrating cerebellum DNA methylation clock
Yucheng Wang
Olivia A. Grant
Leonardo C. Schalkwyk
Original Article Open access 19 August 2023 Pages: 39 - 56
Plasma neurofilament light chain in relation to 10-year change in cognition and neuroimaging markers: a population-based study
Joyce van Arendonk
Frank J. Wolters
M. Arfan Ikram
ORIGINAL ARTICLE Open access 03 August 2023 Pages: 57 - 70
Endocytosis and Alzheimer’s disease
Łukasz Zadka
Marta Sochocka
Jerzy Leszek
REVIEW Open access 30 August 2023 Pages: 71 - 85
Artificial light and neurodegeneration: does light pollution impact the development of Alzheimer’s disease?
Julia Karska
Szymon Kowalski
Jerzy Leszek
Review Open access 21 September 2023 Pages: 87 - 97
Part of 1 collection:

Bridging Geroscience and Neuroscience: Exploring Neurosurgical and Neurological Perspectives on Aging and Age-Related Diseases
Intricate relationship between obstructive sleep apnea and dementia in older adults
Erica Ercolano
Leonardo Bencivenga
Grazia Daniela Femminella
REVIEW Open access 09 October 2023 Pages: 99 - 111
Autonomic nervous system imbalance during aging contributes to impair endogenous anti-inflammaging strategies
Sergio Giunta
Shijin Xia
Fabiola Olivieri
REVIEW Open access 11 October 2023 Pages: 113 - 127
Part of 1 collection:

Bridging Geroscience and Neuroscience: Exploring Neurosurgical and Neurological Perspectives on Aging and Age-Related Diseases
Geroprotective potential of microbiome modulators in the Caenorhabditis elegans model
Brandi C. Miller
Megha Mathai
Shalini Jain
REVIEW Open access 10 August 2023 Pages: 129 - 151
Part of 1 collection:

Animal Models for Translational and Preclinical Geroscience Research
The impact of cardiovascular diagnostics and treatments on fall risk in older adults: a scoping review and evidence map
Anouschka C. Pronk
Liping Wang
Nathalie van der Velde
Review Open access 21 October 2023 Pages: 153 - 169
Comparative analysis of animal lifespan
Nicole C. Riddle
Peggy R. Biga
IISAGE Consortium
REVIEW Open access 27 October 2023 Pages: 171 - 181
Part of 1 collection:

Animal Models for Translational and Preclinical Geroscience Research
Sarcopenia: no consensus, no diagnostic criteria, and no approved indication—How did we get here?
William J. Evans
Jack Guralnik
Ronenn Roubenoff
REVIEW Open access 24 November 2023 Pages: 183 - 190
Part of 1 collection:

Understanding and overcoming the mechanisms driving age-related sarcopenia
The Semmelweis Study: a longitudinal occupational cohort study within the framework of the Semmelweis Caring University Model Program for supporting healthy aging
Zoltan Ungvari
Adam G. Tabák
Bela Merkely
REVIEW Open access 07 December 2023 Pages: 191 - 218
The effect of glycine administration on the characteristics of physiological systems in human adults: A systematic review
Janjira Soh
Shivaanishaa Raventhiran
Andrea B. Maier
REVIEW Open access 18 October 2023 Pages: 219 - 239
Part of 1 collection:

Enhancing Health-span through Anti-Aging Dietary Interventions
A revisiting of “the hallmarks of aging” in domestic dogs: current status of the literature
Ana Gabriela Jiménez
REVIEW 18 August 2023 Pages: 241 - 255
Part of 1 collection:

Aging in Companion Animals
PCSK9: an emerging player in cardiometabolic aging and its potential as a therapeutic target and biomarker
Anna Csiszar
Stefano Tarantini
Zoltan Ungvari
Review Open access 18 December 2023 Pages: 257 - 263
Regional differences in the link between water exchange rate across the blood–brain barrier and cognitive performance in normal aging
Valentinos Zachariou
Colleen Pappas
Brian T. Gold
ORIGINAL ARTICLE Open access 15 September 2023 Pages: 265 - 282
Part of 1 collection:

Bridging Geroscience and Neuroscience: Exploring Neurosurgical and Neurological Perspectives on Aging and Age-Related Diseases
Prediction of cognitive performance differences in older age from multimodal neuroimaging data
Camilla Krämer
Johanna Stumme
Christiane Jockwitz
ORIGINAL ARTICLE Open access 13 June 2023 Pages: 283 - 308
Part of 1 collection:

Bridging Geroscience and Neuroscience: Exploring Neurosurgical and Neurological Perspectives on Aging and Age-Related Diseases
Mild exercise improves executive function with increasing neural efficiency in the prefrontal cortex of older adults
Kyeongho Byun
Kazuki Hyodo
Hideaki Soya
ORIGINAL ARTICLE Open access 15 June 2023 Pages: 309 - 325
Part of 1 collection:

Advances in Neurostimulation in Aging: From Basic Science to Clinical Applications
Rejuvenation of cerebromicrovascular function in aged mice through heterochronic parabiosis: insights into neurovascular coupling and the impact of young blood factors
Rafal Gulej
Ádám Nyúl-Tóth
Zoltan Ungvari
ORIGINAL ARTICLE 21 December 2023 Pages: 327 - 347
Serum factors mediate changes in mitochondrial bioenergetics associated with diet and exercise interventions
Jenny L. Gonzalez-Armenta
Jaclyn Bergstrom
Anthony J. A. Molina
ORIGINAL ARTICLE Open access 27 June 2023 Pages: 349 - 365
Part of 1 collection:

Enhancing Health-span through Anti-Aging Dietary Interventions
Reversal of biological age in multiple rat organs by young porcine plasma fraction
Steve Horvath
Kavita Singh
Harold L. Katcher
Original Article Open access 24 October 2023 Pages: 367 - 394
Part of 1 collection:

Animal Models for Translational and Preclinical Geroscience Research
Fibrinogen in mice cerebral microvessels induces blood–brain barrier dysregulation with aging via a dynamin-related protein 1–dependent pathway
Partha K. Chandra
Manesh Kumar Panner Selvam
David W. Busija
ORIGINAL ARTICLE Open access 28 October 2023 Pages: 395 - 415
Part of 1 collection:

Cell Biology of Vascular Aging
Age-related decline of various cognitive functions in well-experienced male rats treated with the putative anti-aging compound (2R)-1-(1-benzofuran-2-yl)-N-propylpentane-2-amine ((-)BPAP)
Aliz Judit Ernyey
Ferenc Kassai
István Gyertyán
ORIGINAL ARTICLE Open access 12 June 2023 Pages: 417 - 429
Part of 1 collection:

Animal Models for Translational and Preclinical Geroscience Research
Electroencephalogram-based objective assessment of cognitive function level associated with age-related hearing loss
Ran Zhao
Tao Yue
Dong Ming
ORIGINAL ARTICLE 05 June 2023 Pages: 431 - 446
Part of 1 collection:

Bridging Geroscience and Neuroscience: Exploring Neurosurgical and Neurological Perspectives on Aging and Age-Related Diseases
Dorsal and ventral fronto-amygdala networks underlie risky decision-making in age-related cognitive decline
Ping Ren
Manxiu Ma
Guozhi Luo
ORIGINAL ARTICLE Open access 12 September 2023 Pages: 447 - 462
Part of 1 collection:

Advances in Neurostimulation in Aging: From Basic Science to Clinical Applications
Serum neurofilament light and white matter characteristics in the general population: a longitudinal analysis
Marco Hermesdorf
Niklas Wulms
Klaus Berger
ORIGINAL ARTICLE Open access 07 June 2023 Pages: 463 - 472
Resting-state fractal brain connectivity is associated with impaired cognitive performance in healthy aging
Akos Czoch
Zalan Kaposzta
Frigyes Samuel Racz
ORIGINAL ARTICLE Open access 17 July 2023 Pages: 473 - 489
Part of 1 collection:

Advances in Neurostimulation in Aging: From Basic Science to Clinical Applications
Associations between physical exercise type, fluid intelligence, executive function, and processing speed in the oldest-old (85 +)
Brian Duy Ho
Joseph M. Gullett
Ronald A. Cohen
ORIGINAL ARTICLE 31 July 2023 Pages: 491 - 503
Associations of plasma NfL, GFAP, and t-tau with cerebral small vessel disease and incident dementia: longitudinal data of the AGES-Reykjavik Study
April C. E. van Gennip
Claudia L. Satizabal
Thomas T. van Sloten
ORIGINAL ARTICLE Open access 02 August 2023 Pages: 505 - 516
Hyperbaric oxygen alleviates selective domains of cognitive and motor deficits in female 5xFAD mice
Paapa Mensah-Kane
Delaney L. Davis
Nathalie Sumien
ORIGINAL ARTICLE 28 December 2023 Pages: 517 - 530
Whole brain irradiation–induced endothelial dysfunction in the mouse brain
Tamas Kiss
Anna Ungvari
Zoltan Ungvari
Original Article Open access 13 November 2023 Pages: 531 - 541
Part of 1 collection:

Cell Biology of Vascular Aging
Functional network disorganization and cognitive decline following fractionated whole-brain radiation in mice
Benjamin A. Seitzman
Francisco J. Reynoso
Adam Q. Bauer
Original Article Open access 25 September 2023 Pages: 543 - 562
Part of 1 collection:

Advances in Neurostimulation in Aging: From Basic Science to Clinical Applications
Sex difference in brain functional connectivity of hippocampus in Alzheimer’s disease
Jordan Williamson
Shirley A. James
Yuan Yang
ORIGINAL ARTICLE 25 September 2023 Pages: 563 - 572
Part of 1 collection:

Advances in Neurostimulation in Aging: From Basic Science to Clinical Applications
Intrinsic functional brain connectivity changes following aerobic exercise, computerized cognitive training, and their combination in physically inactive healthy late-middle-aged adults: the Projecte Moviment
Stavros I. Dimitriadis
Alba Castells-Sánchez
Maria Mataró
ORIGINAL ARTICLE Open access 23 October 2023 Pages: 573 - 596
Part of 1 collection:

Advances in Neurostimulation in Aging: From Basic Science to Clinical Applications
Frailty is associated with worse executive function and higher cerebral blood velocity in cognitively healthy older adults: a cross-sectional study
Myles W. O’Brien
Nick W. Bray
Said Mekari
Original Article 25 October 2023 Pages: 597 - 607
Part of 1 collection:

Bridging Geroscience and Neuroscience: Exploring Neurosurgical and Neurological Perspectives on Aging and Age-Related Diseases
How cognitive performance changes according to the ankle-brachial index score in an elderly cohort? Results from the Toledo Study of Healthy Ageing
Fabio A. Quiñónez Bareiro
José A. Carnicero
Francisco J. García García
ORIGINAL ARTICLE 23 October 2023 Pages: 609 - 620
Part of 1 collection:

Bridging Geroscience and Neuroscience: Exploring Neurosurgical and Neurological Perspectives on Aging and Age-Related Diseases
Neuropathological and sociodemographic factors associated with the cortical amyloid load in aging and Alzheimer’s disease
Sayonara P. da Silva
Carla C. M. de Castro
Felipe P. Fiuza
ORIGINAL ARTICLE 23 October 2023 Pages: 621 - 643
Part of 1 collection:

Bridging Geroscience and Neuroscience: Exploring Neurosurgical and Neurological Perspectives on Aging and Age-Related Diseases
Increased brain cytokine level associated impairment of vigilance and memory in aged rats can be alleviated by alpha7 nicotinic acetylcholine receptor agonist treatment
Zsolt Kristóf Bali
Lili Veronika Nagy
István Hernádi
ORIGINAL ARTICLE Open access 23 November 2023 Pages: 645 - 664
Part of 1 collection:

Bridging Geroscience and Neuroscience: Exploring Neurosurgical and Neurological Perspectives on Aging and Age-Related Diseases
A randomized placebo-controlled trial of nicotinamide riboside in older adults with mild cognitive impairment
Miranda E. Orr
Eithan Kotkowski
Becky Powers
Original Article 23 November 2023 Pages: 665 - 682
Part of 1 collection:

Enhancing Health-span through Anti-Aging Dietary Interventions
Cerebrospinal fluid neutral lipids predict progression from mild cognitive impairment to Alzheimer’s disease
Farida Dakterzada
Mariona Jové
Gerard Piñol-Ripoll
ORIGINAL ARTICLE Open access 24 November 2023 Pages: 683 - 696
Part of 1 collection:

Bridging Geroscience and Neuroscience: Exploring Neurosurgical and Neurological Perspectives on Aging and Age-Related Diseases
Age-related decrease in inter-subject similarity of cortical morphology and task and resting-state functional connectivity
Junhong Yu
ORIGINAL ARTICLE 25 November 2023 Pages: 697 - 711
Fingerprints of decreased cognitive performance on fractal connectivity dynamics in healthy aging
Zalan Kaposzta
Akos Czoch
Frigyes Samuel Racz
Original Article Open access 20 December 2023 Pages: 713 - 736
Comparative study of machine learning methods for modeling associations between risk factors and future dementia cases
Vaka Valsdóttir
María K. Jónsdóttir
Hlynur Stefánsson
ORIGINAL ARTICLE 23 December 2023 Pages: 737 - 750
The effect of aperiodic components in distinguishing Alzheimer’s disease from frontotemporal dementia
Zhuyong Wang
Anyang Liu
Wangming Zhang
ORIGINAL ARTICLE 19 December 2023 Pages: 751 - 768
Early cerebral amyloid-β accumulation and hypermetabolism are associated with subtle cognitive deficits before accelerated cerebral atrophy
Aftab Bakhtiari
Krisztina Benedek
Mark B. Vestergaard
ORIGINAL ARTICLE Open access 16 December 2023 Pages: 769 - 782
Investigating the association between a history of depression and biomarkers of Alzheimer’s disease, cerebrovascular disease, and neurodegeneration in patients with dementia
Patrick Salwierz
Simrika Thapa
M. Carmela Tartaglia
Original Article 14 December 2023 Pages: 783 - 793
Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used
David E. Harrison
Randy Strong
Richard A. Miller
ORIGINAL ARTICLE Open access 02 December 2023 Pages: 795 - 816
Lifelong exercise training promotes the remodelling of the immune system and prostate signalome in a rat model of prostate carcinogenesis
Elisabete Nascimento-Gonçalves
Fernanda Seixas
Paula A. Oliveira
ORIGINAL ARTICLE Open access 12 May 2023 Pages: 817 - 840
Part of 1 collection:

Animal Models for Translational and Preclinical Geroscience Research
Executive function mediates age-related variation in social integration in female vervet monkeys (Chlorocebus sabaeus)
Jacob D. Negrey
Brett M. Frye
Carol A. Shively
ORIGINAL ARTICLE 23 May 2023 Pages: 841 - 852
Part of 1 collection:

Animal Models for Translational and Preclinical Geroscience Research