Cerebrospinal fluid neutral lipids predict progression from mild cognitive impairment to Alzheimer’s disease
Authors (first, second and last of 7)
Collection
Bridging Geroscience and Neuroscience: Exploring Neurosurgical and Neurological Perspectives on Aging and Age-Related Diseases
The intersection of geroscience and neuroscience holds great potential for advancing our understanding of aging and age-related diseases. This call invites researchers and physicians from clinical neurosurgery, neurology, and neuroscience programs to contribute their insights and findings on the clinical and translational aspects of diseases affecting the central nervous system (CNS) in older adults. We aim to explore how these diseases impact the aging process and the long-term health of individuals, ultimately affecting their quality of life during aging. Additionally, we are particularly interested in papers that investigate the role of basic mechanisms of aging in the pathogenesis of these age-related CNS diseases from a clinical perspective. Click HERE to learn more.
Articles (65 in this collection)
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Increased brain cytokine level associated impairment of vigilance and memory in aged rats can be alleviated by alpha7 nicotinic acetylcholine receptor agonist treatment
Authors (first, second and last of 9)
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Aerobic exercise training effects on hippocampal volume in healthy older individuals: a meta-analysis of randomized controlled trials
Authors (first, second and last of 9)
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Frailty is associated with worse executive function and higher cerebral blood velocity in cognitively healthy older adults: a cross-sectional study
Authors (first, second and last of 9)
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Neuropathological and sociodemographic factors associated with the cortical amyloid load in aging and Alzheimer’s disease
Authors (first, second and last of 6)
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How cognitive performance changes according to the ankle-brachial index score in an elderly cohort? Results from the Toledo Study of Healthy Ageing
Authors (first, second and last of 7)
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Autonomic nervous system imbalance during aging contributes to impair endogenous anti-inflammaging strategies
Authors (first, second and last of 4)
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Beyond the aging spine – a systematic review of functional changes in the human brain in cervical spondylotic myelopathy
Authors (first, second and last of 10)
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Differential predictability of cognitive profiles from brain structure in older males and females
Authors (first, second and last of 4)
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Artificial light and neurodegeneration: does light pollution impact the development of Alzheimer’s disease?
Authors (first, second and last of 8)
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Deep neural network-estimated age using optical coherence tomography predicts mortality
Authors (first, second and last of 11)
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Regional differences in the link between water exchange rate across the blood–brain barrier and cognitive performance in normal aging
Authors (first, second and last of 8)
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Involvement of ApoE4 in dementia with Lewy bodies in the prodromal and demented stages: evaluation of the Strasbourg cohort
Authors (first, second and last of 9)
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Glucose metabolism in posterior cingulate cortex has supplementary value to predict the progression of cognitively unimpaired to dementia due to Alzheimer’s disease: an exploratory study of 18F-FDG-PET
Authors (first, second and last of 8)
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Examining racial differences in the network structure and properties of specific cognitive domains among older adults
Authors (first, second and last of 4)
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Age- and gender-related dispersion of brain networks across the lifespan
Authors (first, second and last of 6)
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Prefrontal hemodynamic features of older adults with preserved visuospatial working memory function
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Investigating the associations between upper limb motor function and cognitive impairment: a scoping review
Authors (first, second and last of 4)
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Prediction of cognitive performance differences in older age from multimodal neuroimaging data
Authors (first, second and last of 8)
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Electroencephalogram-based objective assessment of cognitive function level associated with age-related hearing loss
Authors (first, second and last of 8)
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Low circulating adropin concentrations predict increased risk of cognitive decline in community-dwelling older adults
Authors (first, second and last of 6)
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CCA identifies a neurophysiological marker of adaptation capacity that is reliably linked to internal locus of control of cognition in amnestic MCI
Authors (first, second and last of 5)
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Changes in hippocampal volume during a preceding 10-year period do not correlate with cognitive performance and hippocampal blood‒brain barrier permeability in cognitively normal late-middle-aged men
Authors (first, second and last of 9)
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A sex-stratified analysis of neuroimmune gene expression signatures in Alzheimer’s disease brains
Authors (first, second and last of 9)
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Is an MRI-derived anatomical measure of dementia risk also a measure of brain aging?
Authors (first, second and last of 12)
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Cognition and brain health among older adults in Iceland: the AGES-Reykjavik study
Authors (first, second and last of 7)
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Angiotensin receptor blocker use is associated with upregulation of the memory-protective angiotensin type 4 receptor (AT4R) in the postmortem brains of individuals without cognitive impairment
Authors (first, second and last of 13)
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Age-related decline in circulating IGF-1 associates with impaired neurovascular coupling responses in older adults
Authors (first, second and last of 14)
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Aging: working memory capacity and spatial strategies in a virtual orientation task
Authors (first, second and last of 4)
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Systemic inflammatory markers in relation to cognitive function and measures of brain atrophy: a Mendelian randomization study
Authors (first, second and last of 6)
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A retrotransposon storm marks clinical phenoconversion to late-onset Alzheimer’s disease
Authors (first, second and last of 16)
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Glucose metabolism patterns: A potential index to characterize brain ageing and predict high conversion risk into cognitive impairment
Authors (first, second and last of 9)
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Perceived social isolation is correlated with brain structure and cognitive trajectory in Alzheimer’s disease
Authors (first, second and last of 11)
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Elevated α-synuclein and NfL levels in tear fluids and decreased retinal microvascular densities in patients with Parkinson’s disease
Authors (first, second and last of 4)
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Imaging subtle leaks in the blood–brain barrier in the aging human brain: potential pitfalls, challenges, and possible solutions
Authors (first, second and last of 6)
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Functional and transcriptional profiling of microglial activation during the chronic phase of TBI identifies an age-related driver of poor outcome in old mice
Authors (first, second and last of 12)
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Investigating the combination of plasma amyloid-beta and geroscience biomarkers on the incidence of clinically meaningful cognitive decline in older adults
Authors (first, second and last of 12)
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Analysis of complexity in the EEG activity of Parkinson’s disease patients by means of approximate entropy
Authors (first, second and last of 5)
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Examination of pituitary adenylate cyclase-activating polypeptide in Parkinson’s disease focusing on correlations with motor symptoms
Authors (first, second and last of 14)
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Selective brain regional changes in lipid profile with human aging
Authors (first, second and last of 10)
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Loss of aly/ALYREF suppresses toxicity in both tau and TDP-43 models of neurodegeneration
Authors (first, second and last of 5)
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Cerebral venous congestion exacerbates cerebral microhemorrhages in mice
Authors (first, second and last of 11)
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Molecular markers of DNA repair and brain metabolism correlate with cognition in centenarians
Authors (first, second and last of 9)
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Apolipoprotein E ɛ4–related effects on cognition are limited to the Alzheimer’s disease spectrum
Authors (first, second and last of 5)
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Necroptosis increases with age in the brain and contributes to age-related neuroinflammation
Authors (first, second and last of 6)
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Cognitive decrement in older adults with symptomatic peripheral artery disease
Authors (first, second and last of 10)
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Effect of genetic depletion of MMP-9 on neurological manifestations of hypertension-induced intracerebral hemorrhages in aged mice
Authors (first, second and last of 5)
