Sarcopenia: no consensus, no diagnostic criteria, and no approved indication—How did we get here?
Authors (first, second and last of 9)
Collection
Understanding and overcoming the mechanisms driving age-related sarcopenia
Guest Editors Drs. Paul Greenhaff, Janet M Lord and Niharika Duggal and Editor-in-Chief Dr. Zoltan Ungvari, and the editorial team of GeroScience invite submission of original research articles, opinion papers and review articles related to research focused on understanding the mechanisms that underlie age-related loss of muscle mass and strength (sarcopenia) and how to prevent this.
Editors
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Paul Greenhaff
University of Nottingham, UK
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Janet M Lord
University of Birmingham, UK
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Niharika Duggal
University of Birmingham, UK
Articles (64 in this collection)
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Lower muscle mitochondrial energetics is associated with greater phenotypic frailty in older women and men: the Study of Muscle, Mobility and Aging
Authors (first, second and last of 15)
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Inhibition of p53-MDM2 binding reduces senescent cell abundance and improves the adaptive responses of skeletal muscle from aged mice
Authors (first, second and last of 17)
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Greater myofibrillar protein synthesis following weight-bearing activity in obese old compared with non-obese old and young individuals
Authors (first, second and last of 7)
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Physical activity intensity, frequency, duration, volume and the risk of possible sarcopenia in middle-aged and older adults
Authors (first, second and last of 5)
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Sex-specific alteration in human muscle transcriptome with age
Authors (first, second and last of 9)
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Intermittent treatment with elamipretide preserves exercise tolerance in aged female mice
Authors (first, second and last of 7)
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Sex differences in skeletal muscle-aging trajectory: same processes, but with a different ranking
Authors (first, second and last of 10)
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Genes encoding agrin (AGRN) and neurotrypsin (PRSS12) are associated with muscle mass, strength and plasma C-terminal agrin fragment concentration
Authors (first, second and last of 9)
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Altered T cell infiltration and enrichment of leukocyte regulating pathways within aged skeletal muscle are associated impaired muscle function following influenza infection
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Associations between biomarkers of cellular senescence and physical function in humans: observations from the lifestyle interventions for elders (LIFE) study
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Age- and time-dependent mitochondrial genotoxic and myopathic effects of beta-guanidinopropionic acid, a creatine analog, on rodent skeletal muscles
Authors (first, second and last of 10)
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Proteomic features of skeletal muscle adaptation to resistance exercise training as a function of age
Authors (first, second and last of 11)
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Neither myonuclear accretion nor a myonuclear domain size ceiling is a feature of the attenuated hypertrophic potential of aged human skeletal muscle
Authors (first, second and last of 11)
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CYB5R3 overexpression preserves skeletal muscle mitochondria and autophagic signaling in aged transgenic mice
Authors (first, second and last of 6)
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Obesity as a premature aging phenotype — implications for sarcopenic obesity
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Longitudinal associations between blood lysophosphatidylcholines and skeletal muscle mitochondrial function
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Senolytic treatment rescues blunted muscle hypertrophy in old mice
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The Combined Oral Stable Isotope Assessment of Muscle (COSIAM) reveals D-3 creatine derived muscle mass as a standout cross-sectional biomarker of muscle physiology vitality in older age
Authors (first, second and last of 9)
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A neuromuscular perspective of sarcopenia pathogenesis: deciphering the signaling pathways involved
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Pharmacologic treatment with OKN-007 reduces alpha-motor neuron loss in spinal cord of aging mice
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Intrinsic motoneuron excitability is reduced in soleus and tibialis anterior of older adults
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Six weeks of high-intensity interval training enhances contractile activity induced vascular reactivity and skeletal muscle perfusion in older adults
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Extreme longevity variants at the FOXO3 locus may moderate FOXO3 isoform levels
Authors (first, second and last of 11)
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Reversal of deficits in aged skeletal muscle during disuse and recovery in response to treatment with a secrotome product derived from partially differentiated human pluripotent stem cells
Authors (first, second and last of 10)
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Eat like an athlete: insights of sports nutrition science to support active aging in healthy older adults
Authors (first, second and last of 4)
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Grip strength performance from 9431 participants of the GenoFit study: normative data and associated factors
Authors (first, second and last of 7)
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Interactive effects of aging and aerobic capacity on energy metabolism–related metabolites of serum, skeletal muscle, and white adipose tissue
Authors (first, second and last of 12)
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Combined in vivo muscle mass, muscle protein synthesis and muscle protein breakdown measurement: a ‘Combined Oral Stable Isotope Assessment of Muscle (COSIAM)’ approach
Authors (first, second and last of 8)
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Profiling age-related muscle weakness and wasting: neuromuscular junction transmission as a driver of age-related physical decline
Authors (first, second and last of 8)
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Beta-guanidinopropionic acid has age-specific effects on markers of health and function in mice
Authors (first, second and last of 4)
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Lifelong exercise is associated with more homogeneous motor unit potential features across deep and superficial areas of vastus lateralis
Authors (first, second and last of 8)
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Skeletal muscle mitochondrial DNA copy number and mitochondrial DNA deletion mutation frequency as predictors of physical performance in older men and women
Authors (first, second and last of 11)
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Sex differences in the contribution of different physiological systems to physical function in older adults
Authors (first, second and last of 7)
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Associations of muscle lipid content with physical function and resistance training outcomes in older adults: altered responses with metformin
Authors (first, second and last of 9)
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Effects of 16 months of high intensity resistance training on thigh muscle fat infiltration in elderly men with osteosarcopenia
Authors (first, second and last of 8)
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Thyroid hormone signaling is associated with physical performance, muscle mass, and strength in a cohort of oldest-old: results from the Mugello study
Authors (first, second and last of 8)
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Sarcopenia during COVID-19 lockdown restrictions: long-term health effects of short-term muscle loss
Authors (first, second and last of 6)
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Semiautomatic morphometric analysis of skeletal muscle obtained by needle biopsy in older adults
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Sex differences in changes of protein synthesis with rapamycin treatment are minimized when metformin is added to rapamycin
Authors (first, second and last of 16)
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High-intensity exercise training induces mitonuclear imbalance and activates the mitochondrial unfolded protein response in the skeletal muscle of aged mice
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Regular endurance exercise of overloaded muscle of young and old male mice does not attenuate hypertrophy and improves fatigue resistance
Authors (first, second and last of 5)
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Muscle from aged rats is resistant to mechanotherapy during atrophy and reloading
Authors (first, second and last of 11)
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Poor mitochondrial health and systemic inflammation? Test of a classic hypothesis in the Baltimore Longitudinal Study of Aging
Authors (first, second and last of 7)
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Identification of biomarkers for physical frailty and sarcopenia through a new multi-marker approach: results from the BIOSPHERE study
Authors (first, second and last of 15)
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Vaccination mitigates influenza-induced muscular declines in aged mice
Authors (first, second and last of 6)
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Superoxide-mediated oxidative stress accelerates skeletal muscle atrophy by synchronous activation of proteolytic systems
Authors (first, second and last of 11)
