Professor David E. Smith: A Fearless Scientist and Devoted Mentor Brian ThompsonKim BrouwerMaria M. Posada EditorialNotes 29 November 2023 Pages: 2493 - 2497
Prediction of the Renal Organic Anion Transporter 1 (OAT1)- Mediated Drug Interactions for LY404039, the Active Metabolite of Pomaglumetad Methionil Y. Anne PakMaria M. PosadaKathleen M. Hillgren Original Research Article 12 January 2023 Pages: 2499 - 2511
Application of Pharmacokinetic Modeling to Characterize Hepatobiliary Disposition of Imaging Agents and Alterations due to Liver Injury in Isolated Perfused Rat Livers Angela JeongCatherine M. PastorKim L. R. Brouwer Original Research Article 22 June 2023 Pages: 2513 - 2523
Genome-Wide Association Study for the Genetic Determinants of Thiopurine Methyltransferase Protein Expression in Human Livers and Racial Differences Logan S. SmithXinwen WangHao-Jie Zhu Original Research Article 10 July 2023 Pages: 2525 - 2531
Proton-Coupled Oligopeptide Transport (Slc15) in the Brain: Past and Future Research Jianming XiangRichard F. Keep Review Article 12 June 2023 Pages: 2533 - 2540
The Critical Role of Equilibrative Nucleoside Transporter-2 in Modulating Cerebral Damage and Vascular Dysfunction in Mice with Brain Ischemia-Reperfusion Hui-Ling ChiangKuo-Chen WuChun-Jung Lin Original Research Article 27 July 2023 Pages: 2541 - 2554
Using the LeiCNS-PK3.0 Physiologically-Based Pharmacokinetic Model to Predict Brain Extracellular Fluid Pharmacokinetics in Mice Mohammed A. A. SalehBerfin GülaveElizabeth C. M. de Lange Original Research Article Open access 13 July 2023 Pages: 2555 - 2566
Evaluation of Encequidar as An Intestinal P-gp and BCRP Specific Inhibitor to Assess the Role of Intestinal P-gp and BCRP in Drug-Drug Interactions Jessica ChuErika PanfenHong Shen Original Research Article 31 July 2023 Pages: 2567 - 2584
Oligopeptide/Histidine Transporter PHT1 and PHT2 — Function, Regulation, and Pathophysiological Implications Specifically in Immunoregulation Minlei DongPing LiHuidi Jiang Review Article 23 August 2023 Pages: 2585 - 2596
Incorporating Uremic Solute-mediated Inhibition of OAT1/3 Improves PBPK Prediction of Tenofovir Renal and Systemic Disposition in Patients with Severe Kidney Disease Shih-Yu ChangWeize HuangCatherine K. Yeung Original Research Article 13 September 2023 Pages: 2597 - 2606
Physiological Dynamics in the Upper Gastrointestinal Tract and the Development of Gastrointestinal Absorption Models for the Immediate-Release Oral Dosage Forms in Healthy Adult Human Kai WangGordon L. AmidonDavid E. Smith Review Article 03 October 2023 Pages: 2607 - 2626
Elucidation of Carboxylesterase Mediated Pharmacokinetic Interactions between Irinotecan and Oroxylin A in Rats via Physiologically Based Pharmacokinetic Modeling Jun ZhangYufeng ZhangZhong Zuo Original Research Article 05 September 2023 Pages: 2627 - 2638
Utilization of Rosuvastatin and Endogenous Biomarkers in Evaluating the Impact of Ritlecitinib on BCRP, OATP1B1, and OAT3 Transporter Activity Yeamin HuhAnna PlotkaA. David Rodrigues Original Research Article Open access 10 August 2023 Pages: 2639 - 2651
Integrated Exposure–Response of Dupilumab in Children, Adolescents, and Adults With Atopic Dermatitis Using Categorical and Continuous Efficacy Assessments: A Population Analysis Emily BriggsMohamed A. KamalNidal Huniti Original Research Article Open access 11 December 2023 Pages: 2653 - 2666
Functional Evaluation of P-gp and Bcrp at the Murine Blood-Cerebrospinal Fluid Barrier Austin SunJoanne Wang Original Research Article 13 September 2023 Pages: 2667 - 2675
The Impact of Post-Processing Temperature on PLGA Microparticle Properties Andrew OtteBong Kwan SohKinam Park Original Research Article 17 August 2023 Pages: 2677 - 2685
A Minimal PBPK Model for Plasma and Cerebrospinal Fluid Pharmacokinetics of Trastuzumab after Intracerebroventricular Administration in Patients with HER2-Positive Brain Metastatic Localizations Alicja PuszkielGuilhem BousquetXavier Declèves Original Research Article 11 October 2023 Pages: 2687 - 2697
An Update on Potential Molecular Biomarkers of Dietary Phytochemicals Targeting Lung Cancer Interception and Prevention Rebecca Mary PeterPochung Jordan ChouAh-Ng Tony Kong Review Article 19 September 2023 Pages: 2699 - 2714
Active Uptake of Oxycodone at Both the Blood-Cerebrospinal Fluid Barrier and The Blood-Brain Barrier without Sex Differences: A Rat Microdialysis Study Frida BällgrenMargareta Hammarlund-UdenaesIrena Loryan Original Research Article Open access 23 August 2023 Pages: 2715 - 2730
How Much is Enough? Impact of Efflux Transporters on Drug delivery Leading to Efficacy in the Treatment of Brain Tumors Wenjuan ZhangJu-Hee OhWilliam F. Elmquist Review Article 17 August 2023 Pages: 2731 - 2746
Discovery of the Next Generation of Non-peptidomimetic Neurolysin Activators with High Blood-Brain Barrier Permeability: a Pharmacokinetics Study in Healthy and Stroke Animals Yong ZhangSejal SharmaThomas J. Abbruscato Original Research Article 13 October 2023 Pages: 2747 - 2758