WHAT PROGRAM ANNOUNCEMENTS ARE CURRENTLY OPEN AT THE NIGMS? WHO ARE THE CONTACT PEOPLE? HOW CAN I GET MORE INFORMATION? Rochelle M. Long News Pages: 1425 - 1426
Design of Biological Equivalence Programs for Therapeutic Biotechnology Products in Clinical Development: A Perspective Joyce MordentiJoy A. CavagnaroJames D. Green Commentary Pages: 1427 - 1437
Pharmacokinetic Analysis of Drug Disposition After Intratumoral Injection in a Tissue-Isolated Tumor Perfusion System Akira SaikawaTakehiko NomuraMitsuru Hashida OriginalPaper Pages: 1438 - 1444
Design and Results of a Group Counter-detailing DUR Educational Program Karen B. FarrisDuane M. KirkingRuth Ann C. Opdycke OriginalPaper Pages: 1445 - 1452
Intrinsic Solubility Estimation and pH-Solubility Behavior of Cosalane (NSC 658586), an Extremely Hydrophobic Diprotic Acid Srinivasan VenkateshJianmin LiBradley D. Anderson OriginalPaper Pages: 1453 - 1459
Hydrotropic Solubilization— Mechanistic Studies Renée E. CoffmanDane O. Kildsig OriginalPaper Pages: 1460 - 1463
Stable Formulations of Recombinant Human Growth Hormone and Interferon-γ for Microencapsulation in Biodegradable Mircospheres Jeffrey L. ClelandAndrew J. S. Jones OriginalPaper Pages: 1464 - 1475
Oxidation of Human Insulin-Like Growth Factor I in Formulation Studies, II. Effects of Oxygen, Visible Light, and Phosphate on Methionine Oxidation in Aqueous Solution and Evaluation of Possible Mechanisms Jonas FranssonAnders Hagman OriginalPaper Pages: 1476 - 1481
Synthesis, Antiinflammatory, and Cytotoxic Activities of 2-Alkyl and 2-Benzyl-2-Dimethylaminomethyl-5-(E)-Arylidene Cyclopentanone Hydrochlorides Haitao ChenZhizhong JiVen L. Narayanan OriginalPaper Pages: 1482 - 1487
In Vitro and In Vivo Activity of 16,17-dehydro-epipregnanolones: 17,20-Bond Torsional Energy Analysis and D-ring Conformation Michael B. BolgerScott WielandNancy C. Lan OriginalPaper Pages: 1488 - 1494
Structure-Activity Relationships for Substrates and Inhibitors of Mammalian Liver Microsomal Carboxylesterases Tien L. HuangTakahiro ShiotsukiBruce D. Hammock OriginalPaper Pages: 1495 - 1500
In Vitro-In Vivo Relationship of Oral Extended-Release Dosage Forms Fang-Yu LiuNancy C. SambolChui Yu Liu OriginalPaper Pages: 1501 - 1506
Predicting Injection Site Muscle Damage I: Evaluation of Immediate Release Parenteral Formulations in Animal Models Steven C. SuttonLoreen A. F. EvansKathy A. Norton OriginalPaper Pages: 1507 - 1513
Predicting Injection Site Muscle Damage II: Evaluation of Extended Release Parenteral Formulations in Animal Models Steven C. SuttonLoreen A. F. EvansKathy A. Norton OriginalPaper Pages: 1514 - 1518
Permeation of Buprenorphine and Its 3-Alkyl-Ester Prodrugs Through Human Skin Audra L. StinchcombAnupam PaliwalGordon L. Flynn OriginalPaper Pages: 1519 - 1523
Evaluation of Stereoselective Transdermal Transport and Concurrent Cutaneous Hydrolysis of Several Ester Prodrugs of Propranolol: Mechanism of Stereoselective Permeation Shamim AhmedTeruko ImaiMasaki Otagiri OriginalPaper Pages: 1524 - 1529
Influence of Vehicle, Distant Topical Delivery, and Biotransformation on the Chemopreventive Activity of Apigenin, a Plant Flavonoid, in Mouse Skin Boyong LiHeather PinchDiane R Birt OriginalPaper Pages: 1530 - 1534
Absorption and Presystemic Metabolism of Selegiline Hydrochloride at Different Regions in the Gastrointestinal Tract in Healthy Males Jeffrey S. BarrettPeter SzegoJoyce Ireland OriginalPaper Pages: 1535 - 1540
Effect of Destruction Force on Drug Release from Multiple Unit Controlled Release Dosage Forms in Humans Noriko KatoriWen-Shi MaShigeo Kojima OriginalPaper Pages: 1541 - 1546
A Novel Extravascular Input Function for the Assessment of Drug Absorption in Bioavailability Studies Michael Weiss OriginalPaper Pages: 1547 - 1553
The Relationship Between Rat Intestinal Permeability and Hydrophilic Probe Size Majella E. LaneCaitriona M. O'DriscollOwen I. Corrigan OriginalPaper Pages: 1554 - 1558
Uptake Is the Rate-limiting Step in the Overall Hepatic Elimination of Pravastatin at Steady-state in Rats Masayo YamazakiSayoko AkiyamaYuichi Sugiyama OriginalPaper Pages: 1559 - 1564
Microdialysis Assessment of Microfibrous Collagen Containing a P-Glycoprotein-Mediated Transport Inhibitor, Cyclosporine A, for Local Delivery of Etoposide Hitoshi SatoHidenori KitazawaIsamu Horikoshi OriginalPaper Pages: 1565 - 1569
Fluconazole Distribution to the Brain: A Crossover Study in Freely-moving Rats Using In Vivo Microdialysis Hua YangQin WangWilliam R Elmquist OriginalPaper Pages: 1570 - 1575
Controlled Systemic Absorption and Increased Anesthetic Effect of Bupivacaine Following Epidural Administration of Bupivacaine-Hydroxypropyl-β-Cyclodextrin Complex Jean Christophe FrévilleGilles DolloRoger Le Verge OriginalPaper Pages: 1576 - 1580
Effect of Iontophoresis in Combination with Ionic Enhancers on the Lipid Structure of the Stratum Corneum: An X-ray Diffraction Study Sophie ChesnoyJean DoucetGuy Couarraze Note Pages: 1581 - 1584
Predicting Injection Site Muscle Damage III: Evaluation of Intramuscular Formulations in the L6 Cell Model Loreen A. F. EvansPaul E. GenereuxSteven C. Sutton Note Pages: 1585 - 1587