Regioselective alkylation of 1,3,4,5-tetrahydrobenzo[d]azepin-2-one and biological evaluation of the resulting alkylated products as potentially selective \(\hbox {5-HT}_{\mathrm{2C}}\) agonists Navnit PrajapatiRajani GiridharMange Ram Yadav Full-Length Paper 28 April 2015 Pages: 653 - 667
Synthesis and biological evaluation of (acyl)hydrazones and thiosemicarbazones obtained via in situ condensation of iminium salts with nitrogen-containing nucleophiles Chiara CanevaSilvana AlfeiRoberta Loddo Full-Length Paper 16 June 2015 Pages: 669 - 684
Iodine-catalyzed \(\hbox {sp}^{3}\) C–H bond activation by selenium dioxide: synthesis of diindolylmethanes and di(3-indolyl)selanides P. Seetham NaiduSwarup MajumderPulak J. Bhuyan Full-Length Paper 28 May 2015 Pages: 685 - 693
Copper-catalyzed ligand-free amidation of aryl iodides and amino acid amides to synthesize C3-(Z)-1H-benzo[e][1,4]diazepin-2(3H)-ones Xiao HuYi DongGang Liu Full-Length Paper 07 June 2015 Pages: 695 - 701
A direct access to heptasubstituted biguanides Issa YavariManijeh Nematpour Full-Length Paper 30 April 2015 Pages: 703 - 708
One-pot four-component synthesis of highly substituted [1,2,4]triazolo[1,5-a]pyrimidines Ahmad ShaabaniMozhdeh SeyyedhamzehMahsa Armaghan Full-Length Paper 28 May 2015 Pages: 709 - 715
Stereoselective chlorothiolation of artemisinin-derived C-10 oxa terminal alkynes Naresh SurineniPori BuragohainNabin C. Barua Full-Length Paper 19 June 2015 Pages: 717 - 724
Synthesis of 2-(2,4-dihydroxyphenyl)thieno-1,3-thiazin-4-ones, their lipophilicity and anticancer activity in vitro Joanna MatysiakMałgorzata JuszczakWojciech Rzeski Full-Length Paper 29 April 2015 Pages: 725 - 736
Synthesis and antiproliferative activity of pterostilbene and \(3^\prime \)-methoxy pterostilbene Mannich base derivatives against Hela cells Chongyang LiuLinpei DongQiuan Wang Full-Length Paper Open access 11 July 2015 Pages: 737 - 743
Synthesis and anticancer activity of novel fused pyrimidine hybrids of myrrhanone C, a bicyclic triterpene of Commiphora mukul gum resin Uppuluri Venkata MallavadhaniMadasu ChandrashekharSistla Ramakrishna Full-Length Paper 01 August 2015 Pages: 745 - 757
A facile environment-friendly one-pot two-step regioselective synthetic strategy for 3,7-diarylpyrazolo[1,5-a]pyrimidines related to zaleplon and 3,6-diarylpyrazolo[1,5-a]pyrimidine-7-amines assisted by KHSO\(_{4}\) in aqueous media Asem Satyapati DeviShunan KapingJai Narain Vishwakarma Full-Length Paper 28 May 2015 Pages: 759 - 771
Synthesis of enyne and aryl vinyl sulfoxides: functionalization via Pummerer rearrangement Frederico B. SouzaAnwar ShamimHélio A. Stefani Full-Length Paper 01 August 2015 Pages: 773 - 785
Design, synthesis, in vitro cytotoxic activity evaluation, and apoptosis-induction study of new 9(10H)-acridinone-1,2,3-triazoles Maryam Mohammadi-KhanaposhtaniMaliheh SafaviTahmineh Akbarzadeh Full-Length Paper 14 July 2015 Pages: 787 - 795
Combined isocyanide-based multi-component Ullmann-type reaction: an efficient access to novel nitrogen-containing pentacyclic compounds Shima DianatMohammad MahdaviAlireza Foroumadi Full-Length Paper 01 August 2015 Pages: 797 - 805
General synthesis of 2,1-benzisoxazoles (anthranils) from nitroarenes and benzylic C–H acids in aprotic media promoted by combination of strong bases and silylating agents Michał WiȩcławMariusz BobinKrzysztof Wojciechowski Full-Length Paper Open access 11 August 2015 Pages: 807 - 816
Synthesis and antidepressant activities of 4-(substituted-phenyl)tetrazolo[1,5-a]quinazolin-5(4H)-ones and their derivatives Hong-Jian ZhangShi-Ben WangZhe-Shan Quan Full-Length Paper 07 August 2015 Pages: 817 - 828
Structure–activity relationship studies on quinoxalin-2(1H)-one derivatives containing thiazol-2-amine against hepatitis C virus leading to the discovery of BH6870 Qi-Fei ZhongRui LiuGang Liu Full-Length Paper 24 July 2015 Pages: 829 - 853
In silico identification of targets for a novel scaffold, 2-thiazolylimino-5-benzylidin-thiazolidin-4-one Poornima IyerJahnavi BollaM. Elizabeth Sobhia Full-Length Paper 19 April 2015 Pages: 855 - 870
Exploring structural requirements for peripherally acting 1,5-diaryl pyrazole-containing cannabinoid 1 receptor antagonists for the treatment of obesity Mayank Kumar SharmaPrashant R. MurumkarMange Ram Yadav Full-Length Paper 17 July 2015 Pages: 871 - 893
Fragment virtual screening based on Bayesian categorization for discovering novel VEGFR-2 scaffolds Yanmin ZhangYu JiaoYadong Chen Full-Length Paper 29 May 2015 Pages: 895 - 913
Analysis of B-Raf\(^{\mathrm{V600E}}\) inhibitors using 2D and 3D-QSAR, molecular docking and pharmacophore studies Reza AalizadehEslam PourbasheerMohammad Reza Ganjali Full-Length Paper 15 August 2015 Pages: 915 - 930
Modelling the molecular mechanism of protein–protein interactions and their inhibition: CypD–p53 case study S. M. FayazG. K. Rajanikant Full-Length Paper 14 July 2015 Pages: 931 - 943
In silico prediction of drug-induced myelotoxicity by using Naïve Bayes method Hui ZhangPeng YuJi Zhang Full-Length Paper 11 July 2015 Pages: 945 - 953
Large-scale structure-activity relationship study of hepatitis C virus NS5B polymerase inhibition using SMILES-based descriptors Apilak WorachartcheewanVirapong PrachayasittikulChanin Nantasenamat Full-Length Paper 12 July 2015 Pages: 955 - 964
Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one derivatives as Aurora A kinase inhibitors: LQTA-QSAR analysis and detailed systematic validation of the developed model Ashish M. KanhedRadha Charan DashMange Ram Yadav Full-Length Paper 17 July 2015 Pages: 965 - 974
Latest QSAR study of adenosine A\(_{\mathrm{2B}}\) receptor affinity of xanthines and deazaxanthines Alfonso Pérez-GarridoVirginia Rivero-BucetaMarta Teijeira Bautista Full-Length Paper 10 July 2015 Pages: 975 - 989
Screening of potential targets in Plasmodium falciparum using stage-specific metabolic network analysis Neel DholakiaPinakin DhandhukiaNilanjan Roy Full-Length Paper 25 August 2015 Pages: 991 - 1002
Discovery of new \({\varvec{Mycobacterium~tuberculosis}}\) proteasome inhibitors using a knowledge-based computational screening approach Rukmankesh MehraReena ChibAmit Nargotra Full-Length Paper 01 August 2015 Pages: 1003 - 1019
Activity cliffs and activity cliff generators based on chemotype-related activity landscapes Jaime Pérez-VillanuevaOscar Méndez-LucioJosé L. Medina-Franco Full-Length Paper 07 July 2015 Pages: 1021 - 1035
