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A direct access to heptasubstituted biguanides

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Abstract

An efficient and experimentally simple copper-catalyzed carbon–nitrogen bond formation for the synthesis of \(N\)-arylated biguanides starting from aryl halides, carbodiimides, and 1,1,3,3-tetramethylguanidine is reported. The potential diversity of this type of reaction, easily available starting materials, and commercially available low-cost catalysts are the incremental features of this methodology.

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Authors and Affiliations

  1. Department of Chemistry, Tarbiat Modares University, PO Box 14115-175, Tehran, Iran

    Issa Yavari & Manijeh Nematpour

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  1. Issa Yavari
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  2. Manijeh Nematpour
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Correspondence to Issa Yavari.

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Yavari, I., Nematpour, M. A direct access to heptasubstituted biguanides. Mol Divers 19, 703–708 (2015). https://doi.org/10.1007/s11030-015-9601-7

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  • DOI: https://doi.org/10.1007/s11030-015-9601-7

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