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A Liaison Brought to Light: Cerebellum-Hippocampus, Partners for Spatial Cognition

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Abstract

This review focuses on the functional and anatomical links between the cerebellum and the hippocampus and the role of their interplay in goal-directed navigation and spatial cognition. We will describe the interactions between the cerebellum and the hippocampus at different scales: a macroscopic scale revealing the joint activations of these two structures at the level of neuronal circuits, a mesoscopic scale highlighting the synchronization of neuronal oscillations, and finally a cellular scale where we will describe the activity of hippocampal neuronal assemblies following a targeted manipulation of the cerebellar system. We will take advantage of this framework to summarize the different anatomical pathways that may sustain this multiscale interaction. We will finally consider the possible influence of the cerebellum on pathologies traditionally associated with hippocampal dysfunction.

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Funding

The National Agency for Research ANR-17-CE16-0019–03 (SynPredict) and ANR-18-CE16-0010–02 (RewInhib) supported LRR and MF. ANR-17-CE37-0015–02 (Navi-GPS) and SATT Lutech supported LRR and ALP.

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  1. Institut de Biologie Paris Seine (IBPS), Cerebellum Navigation and Memory Team (CeZaMe), Sorbonne Université, CNRS, INSERM, Neurosciences Paris Seine (NPS), 75005, Paris, France

    Laure Rondi-Reig, Anne-Lise Paradis & Mehdi Fallahnezhad

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  1. Laure Rondi-Reig
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  2. Anne-Lise Paradis
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  3. Mehdi Fallahnezhad
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Correspondence to Laure Rondi-Reig.

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Rondi-Reig, L., Paradis, AL. & Fallahnezhad, M. A Liaison Brought to Light: Cerebellum-Hippocampus, Partners for Spatial Cognition. Cerebellum 21, 826–837 (2022). https://doi.org/10.1007/s12311-022-01422-3

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