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Brain Pericytes: Emerging Concepts and Functional Roles in Brain Homeostasis

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Abstract

Brain pericytes are an important constituent of neurovascular unit. They encircle endothelial cells and contribute to the maturation and stabilization of the capillaries in the brain. Recent studies have revealed that brain pericytes play pivotal roles in a variety of brain functions, such as regulation of capillary flow, angiogenesis, blood brain barrier, immune responses, and hemostasis. In addition, brain pericytes are pluripotent and can differentiate into different lineages similar to mesenchymal stem cells. The brain pericytes are revisited as a key player to maintain brain function and repair brain damage.

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Acknowledgments

This study was partially supported by Coordination, Support and Training Program for Translational Research and Grant-in-Aid for Scientific Research (C 19590992, C 22590937) from The Japanese Ministry of Education, Culture, Sports, Science and Technology. We are grateful to Dr. Masanori Wakisaka for his helpful comments.

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  1. Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-8582, Japan

    Masahiro Kamouchi, Tetsuro Ago & Takanari Kitazono

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  1. Masahiro Kamouchi
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Correspondence to Masahiro Kamouchi.

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Kamouchi, M., Ago, T. & Kitazono, T. Brain Pericytes: Emerging Concepts and Functional Roles in Brain Homeostasis. Cell Mol Neurobiol 31, 175–193 (2011). https://doi.org/10.1007/s10571-010-9605-x

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