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Effect of Cytotoxic Compounds on Activity of Antioxidant Enzyme System in MCF-7 and H1299 Cells

  • Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

We studied the function of the antioxidant system in tumor cell lines MCF-7 and H1299 that differ by the state of tumor suppressor gene p53. Exposure to different classes of cytotoxic compounds induced several types of antioxidant system responses that depend on the type of cell line. The effects of platinum(II) and platinum(IV) complexes on activity of antioxidant enzymes vary, which can be explained by differences in their accumulation and biotransformation in tumor cells. Triazole and oxazolidinone derivatives had little effect on activity of superoxide dismutase and catalase in H1299 cells, but increased superoxide dismutase activity in MCF-7 cells.

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Authors and Affiliations

  1. Institute of Problems Chemical Physics, Russian Academy of Sciences, Chernogolovka, Russia

    V. A. Mumyatova, A. A. Balakina, N. V. Filatova, V. D. Sen’, A. G. Korepin & A. A. Terentev

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  1. V. A. Mumyatova
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  2. A. A. Balakina
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  3. N. V. Filatova
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  4. V. D. Sen’
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  5. A. G. Korepin
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  6. A. A. Terentev
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Correspondence to V. A. Mumyatova.

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Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 1, pp. 45-49, January, 2016

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Mumyatova, V.A., Balakina, A.A., Filatova, N.V. et al. Effect of Cytotoxic Compounds on Activity of Antioxidant Enzyme System in MCF-7 and H1299 Cells. Bull Exp Biol Med 161, 179–183 (2016). https://doi.org/10.1007/s10517-016-3371-9

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  • DOI: https://doi.org/10.1007/s10517-016-3371-9

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