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Cytostatic action of triazole and oxazolidinone derivatives

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Abstract

We synthesized a number of derivatives of 1,2,3-benzotriazole, 1,2,4-triazole, and oxazolidine-2-one derivatives, among which compounds suppressing the growth of the tumor cells HeLa and H1299 were revealed. The studies of the effect of these compounds on the cell cycle and activity of caspase dependent degradation of poly(ADP-ribose) polymerase showed that these compounds at the IC50 doses exhibit cytostatic effect on tumor cells. In the MCF7 cells, these compounds induce an increase in expression of the tumor suppressor p53.

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Authors and Affiliations

  1. Institute of Problems of Chemical Physics, Russian Academy of Sciences, 1 prosp. Akad. Semenova, 142432, Chernogolovka, Moscow region, Russian Federation

    V. A. Derevkova, R. I. Papina, A. G. Korepin, N. M. Glushakova & A. A. Terent’ev

  2. N. I. Lobachevsky Nizhni Novgorod State University, 23 prosp. Gagarina, 603950, Nizhny Novgorod, Russian Federation

    I. V. Balalaeva

Authors
  1. V. A. Derevkova
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  2. I. V. Balalaeva
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  3. R. I. Papina
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  4. A. G. Korepin
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  5. N. M. Glushakova
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  6. A. A. Terent’ev
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Correspondence to A. A. Terent’ev.

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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 6, pp. 1141–1145, June, 2011.

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Derevkova, V.A., Balalaeva, I.V., Papina, R.I. et al. Cytostatic action of triazole and oxazolidinone derivatives. Russ Chem Bull 60, 1166–1171 (2011). https://doi.org/10.1007/s11172-011-0183-y

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  • DOI: https://doi.org/10.1007/s11172-011-0183-y

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