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Gastrointestinal dysfunction in the synucleinopathies

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Abstract

Interest in gastrointestinal dysfunction in Parkinson’s disease has blossomed over the past 30 years and has generated a wealth of investigation into this non-motor aspect of the disorder, research that has encompassed its pathophysiology, its clinical features, and its impact on quality of life. The question of gastrointestinal dysfunction in the other synucleinopathies has not received nearly as much attention, but information and knowledge are growing. In this review, the current knowledge, controversies, and gaps in our understanding of the pathophysiology of gastrointestinal dysfunction in Parkinson’s disease and the other synucleinopathies will be addressed, and extended focus will be directed toward the clinical problems involving saliva management, swallowing, gastric emptying, small intestinal function, and bowel function that are so problematic in these disorders.

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Fig. 1

Modified from Pfeiffer RF. Autonomic dysfunction in Parkinson’s disease. Neurotherapeutics 2020 [269]

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  1. Department of Neurology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR, 97239-3098, USA

    Kathryn A. Chung & Ronald F. Pfeiffer

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Kathryn A. Chung, MD: none. Ronald F. Pfeiffer, MD: consulting honoraria—Acadia, Acorda; lecture honoraria—Acadia; royalties for book editing—CRC Press, Humana Press; legal consulting fees—Henry and Beaver LLP.

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Chung, K.A., Pfeiffer, R.F. Gastrointestinal dysfunction in the synucleinopathies. Clin Auton Res 31, 77–99 (2021). https://doi.org/10.1007/s10286-020-00745-7

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