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Prevalence of small intestinal bacterial overgrowth in Chinese patients with Parkinson’s disease

  • Neurology and Preclinical Neurological Studies - Original Article
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Abstract

Parkinson’s disease (PD) is associated with gastrointestinal motility abnormalities that could favor the occurrence of small intestinal bacterial overgrowth (SIBO). The aim of the study was to assess the prevalence of SIBO in Chinese patients with PD and the potential impact of SIBO on gastrointestinal symptoms and motor function. 182 consecutive Chinese patients with PD patients and 200 sex, age, and BMI-matched subjects without PD were included. All participants underwent the glucose breath test to assess SIBO. We examined the associations between factors and SIBO with logistic regression using SPSS. Fifty-five of the 182 PD patients were SIBO positive (30.2 %; 95 % CI 23.5–36.9 %) compared with 19 of 200 in the control group (9.5 %; 95 % CI 5.4–13.6 %); the difference was statistically significant (P < 0.0001; OR 4.13; 95 % CI 2.34–7.29). Motor fluctuations present was higher in the PD patients with SIBO than in the patients without SIBO (70.9 vs. 45.7 %; P = 0.002). Multivariate analysis showed that disease duration, Hoehn and Yahr stage, Unified PD Rating-III score, Unified PD Rating-IV score, and Non-Motor Symptoms Scale score were the factors associated with the SIBO-positive status in PD patients. SIBO was highly prevalent in PD, and nearly one-third was detected. SIBO was associated with worse gastrointestinal symptoms and worse motor function. Further studies are needed to specify the reasons underlying SIBO and worse motor function in PD.

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Acknowledgments

We express our gratitude to all the participations, the nurses, and physicians who participated in this study, and thereby made this work possible. We especially want to express our gratitude to those doctors who participated in the samples collection and tested. We also acknowledge the contribution of reviewers who have helped us to improve the manuscript.

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Authors and Affiliations

  1. Department of Neurology, The First Affiliated Hospital of Xinxiang Medical University, No. 88. Jiankang Road, Weihui, Xinxiang, 453100, Henan, People’s Republic of China

    Xiao-Lu Niu, Li Liu, Zhi-Xiu Song, Qing Li, Zhi-Hua Wang, Jian-Long Zhang & He-Hua Li

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  1. Xiao-Lu Niu
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  2. Li Liu
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  3. Zhi-Xiu Song
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  4. Qing Li
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  5. Zhi-Hua Wang
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  7. He-Hua Li
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Correspondence to He-Hua Li.

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All authors have read the journal’s policy on conflicts of interest and have disclosed none potential conflicts of interest.

Research involving human participants

This study was approved by the Institutional Review Board of the First Affiliated Hospital of Xinxiang Medical University.

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Informed written consent was obtained from each patient, family, or legal guardian.

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Niu, XL., Liu, L., Song, ZX. et al. Prevalence of small intestinal bacterial overgrowth in Chinese patients with Parkinson’s disease. J Neural Transm 123, 1381–1386 (2016). https://doi.org/10.1007/s00702-016-1612-8

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  • DOI: https://doi.org/10.1007/s00702-016-1612-8

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