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Metastatic bone disease from breast cancer: a review of minimally invasive techniques for diagnosis and treatment

  • General Review • TUMORS - METASTASES
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European Journal of Orthopaedic Surgery & Traumatology Aims and scope Submit manuscript

Abstract

Skeletal-related events in patients with metastatic bone disease include intractable severe pain, pathologic fracture, spinal cord and nerve compression, hypercalcemia and bone marrow aplasia. In patients with breast cancer, the skeleton is the most frequent site for metastases. Treatment options for metastatic bone disease in these patients include bisphosphonates, chemotherapeutic agents, opioids, hormonal therapy, minimally invasive/interventional and surgical techniques. Interventional oncology techniques for breast cancer patients with bone metastases include diagnostic (biopsy) and therapeutic (palliative and curative) approaches. In the latter, percutaneous ablation, augmentation and stabilization are included. The purpose of this article is to describe the basic concepts of biopsy, ablation, embolization and peripheral skeleton augmentation techniques in patients with metastatic bone disease from breast carcinoma. The necessity for a tailored approach applying different techniques for different cases and locations will be addressed.

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Authors and Affiliations

  1. Second Department of Radiology, National and Kapodistrian University of Athens, School of Medicine, Attikon University General Hospital, 41 Ventouri Street, Holargos, 15562, Athens, Greece

    Dimitrios Filippiadis, Argyro Mazioti, Konstantinos Palialexis & Alexis Kelekis

  2. First Department of Orthopaedics, Attikon University General Hospital, 41 Ventouri Street, Holargos, 15562, Athens, Greece

    Andreas F. Mavrogenis, Panayiotis D. Megaloikonomos & Panayiotis J. Papagelopoulos

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  1. Dimitrios Filippiadis
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  2. Andreas F. Mavrogenis
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  3. Argyro Mazioti
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  4. Konstantinos Palialexis
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  5. Panayiotis D. Megaloikonomos
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  6. Panayiotis J. Papagelopoulos
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  7. Alexis Kelekis
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Correspondence to Dimitrios Filippiadis.

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Filippiadis, D., Mavrogenis, A.F., Mazioti, A. et al. Metastatic bone disease from breast cancer: a review of minimally invasive techniques for diagnosis and treatment. Eur J Orthop Surg Traumatol 27, 729–736 (2017). https://doi.org/10.1007/s00590-017-1986-9

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