Abstract
Background
The risk factors and incidence of anastomotic leak following colorectal surgery are well reported in the literature. However, the management of the multiple clinical scenarios that may be encountered has not been standardized.
Methods
The medical literature from 1973 to 2007 was reviewed using PubMed for papers relating to anastomotic leaks and abdominal abscess, with a specific emphasis on predisposing factors, prevention strategies, and treatment approaches. A six-round modified Delphi research method was utilized to find consensus among a group of expert colorectal surgeons and interventional radiologists regarding standardized management algorithms for anastomotic leaks.
Results
Management scenarios were divided into those for intraperitoneal anastomoses, extraperitoneal (low pelvic) anastomoses, and anastomoses with proximal diverting stomas. Management options were then based on the clinical presentation and radiographic findings and organized into three interconnected algorithms.
Conclusions
This process was a useful first step toward establishing guidelines for the management of anastomotic leak.
Similar content being viewed by others
References
Peel AL, Taylor EW (1991) Proposed definitions for the audit of postoperative infection: A discussion paper. Surgical Infection Study Group. Ann R Coll Surg Engl 73:385–388
Schrock TR (2005) Anastomotic leak after colon and rectal resections. In Current Therapy in Colon and Rectal Surgery. 2nd edition. Fazio VW, Church JM, and Delaney CP eds. (Philadelphia, PA): Mosby, pp 525–528
Galandiuk S (2005) To drain or not to drain. Ann Surg 241:14–15
Alberts JCJ, Parvaiz A, Moran BJ (2003) Predicting risk and diminishing the consequences of anastomotic dehiscence following rectal resection. Colorectal Dis 5:478–482
Fielding LP, Stewart-Brown S, Blesovsky L et al (1980) Anastomotic integrity after operations for large-bowel cancer: A multicentre study. BMJ 281:411–414
Ansari MZ, Collopy BT, Hart WG et al (2000) In-hospital mortality and associated complications after bowel surgery in Victorian public hospitals. ANZ J Surg 70:6–10
Mäkelä JT, Kiviniemi H, Laitnen S (2003) Risk factors for anastomotic leak after left-sided colorectal resection with rectal anastomosis. Dis Colon Rectum 46:653–660
Braga M, Vignali A, Zuliani W et al (2005) Laparoscopic versus open colorectal surgery: cost-benefit analysis in a single-center randomized trial. Ann Surg 242:890–895, discussion 895–896
Golub R, Golub RW, Cantu R Jr et al (1997) A multivariate analysis of factors contributing to leakage of intestinal anastomoses. J Am Coll Surg 184:364–372
Alves A, Panis Y, Pocard M et al (1999) Management of anastomotic leak after non-diverted large bowel resection. J Am Coll Surg 189:554–559
Branagan G, Finnis D (2005) Prognosis after anastomotic leak in colorectal surgery. Dis Colon Rectum 48:1021–1026
Merkel S, Wang WY, Schmidt O et al (2001) Locoregional recurrence in patients with anastomotic leak after anterior resection for rectal carcinoma. Colorectal Dis 3:154–160
Chang SC, Lin JK, Yang SH et al (2003) Long-term outcome of anastomosis leak after curative resection for mid and low rectal cancer. Hepatgastroenterology 50:1898–1902
Walker KG, Bell SW, Rickard MJ et al (2004) Anastomotic leak is predictive of diminished survival after potentially curative resection for colorectal cancer. Ann Surg 240:255–259
Bell SW, Walker KG, Rickard MJ et al (2003) Anastomotic leak after curative anterior resection results in higher prevalence of local recurrence. Br J Surg 90:1261–1266
Nesbakken A, Nygaard K, Lunde OC (2001) Outcome and late functional results after anastomotic leak following mesorectal excision for rectal cancer. Br J Surg 88:400–404
Heald RJ, Leicester RJ (1981) The low stapled anastomosis. Br J Surg 68:333–337
Bellamy N, Anastassiades P, Watson-Buchanan W et al (1991) Rheumatoid arthritis antirheumatic drug trials. III. Setting the delta for clinical trials of antirheumatic drugs—results of a consensus development (Delphi) exercise. J Rheumatol 18:1908–1915
Clayton MJ (1997) Delphi: a technique to harness expert opinion for critical decision-making tasks in education. Educ Psychol 17:373–386
Critcher C, Gladstone B (1998) Utilizing the Delphi technique in policy discussion: a case study of a privatized utility in Britain. Public Admin 76:431–449
Jones J, Hunter D (1995) Consensus methods for medical and health services research. BMJ 311:376–380
de Villiers MR, de Villiers PJ, Kent AP (2005) The Delphi technique in health sciences education research. Med Teach 27:639–643
Roddy E, Zhang W, Doherty M et al (2006) Evidence-based clinical guidelines: a new system to better determine true strength of recommendation. J Eval Clin Pract 12:347–352
Oncel M, Remzi FH (2003) Perioperative complications in colorectal surgery. Clin Colon Rectal Surg 16:143–152
Truong S, Bohm G, Klinge U et al (2004) Results after endoscopic treatment of postoperative upper gastrointestinal fistulas and leaks using combined Vicryl plug and fibrin glue. Surg Endosc 18:1105–1108
Bonanomi G, Prince JM, McSteen F et al (2004) Sealing effect of fibrin glue on the healing of gastrointestinal anastomoses: implications for the endoscopic treatment of leaks. Surg Endosc 18:1620–1624
Nesbakken A, Nygaard K, Lunde OC et al (2005) Anastomotic leak following mesorectal excision for rectal cancer: true incidence and diagnostic challenges. Colorectal Dis 7:576–581
Kumar RR, Kim JT, Haukoos JS et al (2006) Factors affecting the successful management of intra-abdominal abscesses with antibiotics and the need for percutaneous drainage. Dis Colon Rectum 49:183–189
Haaga JR, Nakamoto D, Stellato T et al (2000) Intracavitary urokinase for enhancement of percutaneous abscess drainage: phase II trial. AJR Am J Roentgenol 174:1681–1685
Haaga JR, Nakamoto D (2004) Computed tomography-guided drainage of intra-abdominal infections. Curr Infect Dis Rep 6:105–114
Siewert B, Tye G, Kruskal J et al (2006) Impact of CT-guided drainage in the treatment of diverticular abscesses: size matters. AJR Am J Roentgenol 186:680–686
Whitlow CB, Opelka FG, Gathright JB Jr et al (1997) Treatment of colorectal and ileoanal anastomotic sinuses. Dis Colon Rectum 40:760–763
Fleshman JW, McLeod RS, Cohen Z et al (1988) Improved results following use of an advancement technique in the treatment of ileoanal anastomotic complications. Int J Colorectal Dis 3:161–165
Schrock TR, Deveney CW, Dunphy JE (1973) Factors contributing to leak of colonic anastomoses. Ann Surg 177:513–518
Brennan SS, Pickford IR, Evans M et al (1982) Staples or sutures for colonic anastomoses: a controlled clinical trial. Br J Surg 69:722–724
McGinn FP, Gartell PC, Clifford PC et al (1985) Staples or sutures for low colorectal anastomoses: a prospective randomized trial. Br J Surg 72:603–605
Beard JD, Nicholson ML, Sayers RD et al (1990) Intraoperative air testing of colorectal anastomosis: a prospective, randomized trial. Br J Surg 77:1095–1097
Mealy K, Burke P, Hyland J (1992) Anterior resection with a defunctioning colostomy: Questions of safety. Br J Surg 79:305–317
Kracht M, Hay JM, Fagniez PL et al (1993) Ileocolonic anastomosis after right hemicolectomy for carcinoma: stapled or hand-sewn? A prospective, multicenter, randomized trial. Int J Colorectal Dis 8:29–33
Redmond HP, Austin OM, Clery AP et al (1993) Safety of double-stapled anastomosis in low anterior resection. Br J Surg 80:924–927
Karanjia ND, Corder AP, Bearn P et al (1994) Leakage from stapled low anastomosis after total mesorectal excision for carcinoma of the rectum. Br J Surg 81:1224–1226
Santos JC Jr, Batista J, Sirimarco MT et al (1994) Prospective randomized trial of mechanical bowel preparation in patients undergoing elective colorectal surgery. Br J Surg 81:1673–1676
Fingerhut A, Hay JM, Elhadad A et al (1995) Supraperitoneal colorectal anastomosis: hand-sewn versus circular staples–a controlled clinical trial; French Associations for Surgical Research. Surgery 118:479–485
Sagar PM, Hartley MN, Macfie J et al (1995) Randomized trial of pelvic drainage after rectal resection. Dis Colon Rectum 38:254–258
Hansen O, Schwenk W, Hucke HP et al (1996) Colorectal stapled anastomoses. Experiences and results. Dis Colon Rectum 39:30–36
Mann B, Kleinschmidt S, Stremmel W (1996) Prospective study of hand-sutured anastomosis after colorectal resection. Br J Surg 83:29–31
Vignali A, Fazio VW, Lavery IC et al (1997) Factors associated with the occurrence of leaks in stapled rectal anastomoses: a review of 1,014 patients. J Am Coll Surg 185:105–113
Dehni N, Schlegel RD, Cunningham C et al (1998) Influence of a defunctioning stoma on leakage rates after low colorectal anastomosis and colonic J pouch-anal anastomosis. Br J Surg 85:1114–1117
Peterson S, Freitag M, Hellmich G et al (1998) Anastomotic leak: Impact on local recurrence and survival in surgery of colorectal cancer. Int J Colorectal Dis 13:160–163
Rullier E, Laurent C, Garrelon JL et al (1998) Risk factors for anastomotic leak after resection for rectal cancer. Br J Surg 85:355–358
Watson AJM, Krukowski ZH, Munro A (1999) Salvage of large bowel anastomotic leak. Br J Surg 86:499–500
Marijnen CA, Kapiteijn E, van de Velde CJ et al (2002) Acute side effects and complications after short-term preoperative radiotherapy combined with total mesorectal excision in primary rectal cancer. J Clin Oncol 20:817–825
Marusch F, Koch A, Schmidt U et al (2002) Value of a protective stoma in low anterior resections for rectal cancer. Dis Colon Rectum 45:1164–1171
Wong NY, Eu KW (2005) A defunctioning ileostomy does not prevent clinical anastomotic leak after a low anterior resection: a prospective, comparative study. Dis Colon Rectum 48:2076–2079
Platell C, Barwood N, Dorfmann G,et al (2007) The incidence of anastomotic leaks in patients undergoing colorectal surgery. Colorectal Dis 9:71–79
Acknowledgments
The International Anastomotic Leak Study Group consisted of an initial hypothesis group of R. Phitayakorn, C.P. Delaney, H.L. Reynolds, B.J. Champagne, A.G. Heriot, P. Neary, A.J. Senagore and an international collaborative group of the following coauthors: P. Ambrosetti, University Hospital, Geneva, Switzerland; C. Bailey, Universite Louis Pasteur, Strasbourg, France; R.P. Billingham, University of Washington, Seattle, Washington, USA; M. Braga, San Raffaele University Vita-Salute, Milan, Italy; W.D. Buie, University of Calgary, Calgary, Alberta, Canada; A.W. Darzi, Imperial College, London, UK; P.R. Douglas, Prince of Wales Hospital, University of New South Wales, Sydney, Australia; E.J. Dozois, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN, USA; N.S. Fearnhead, Addenbrooke’s Hospital, Cambridge, UK; F.A. Frizelle, Christchurch Hospital, Christchurch, New Zealand; S.L. Gearhart, Johns Hopkins Medical Institutions, Lutherville, MD, USA; Q.H. Gonzalez, Instituto Nacional de Ciencias Medicas y Nutricion S.Z., Tlalpan, Mexico City, Mexico; J.R. Haaga, University Hospitals of Cleveland, Cleveland, OH, USA; G.J. Harris, St. Richard’s Hospital, West Sussex, UK; A.F. Horgan, Freeman Hospital, Newcastle Upon Tyne, UK; P.G. Horgan, Glasgow Royal Infirmary, Alexandra Parade, Glasgow, Scotland, UK; H. Kehlet, The Juliane Marie Centre, Rigshospitalet, Copenhagen, Denmark; S.H. Kim, Korea University Hospital, Seoul, Korea; A.M. Lacy, University of Barcelona, Barcelona, Spain; J. Leroy, Universite Louis Pasteur, Strasbourg, France; F. López-Kostner, Hospital Clínico Pontificia Universidad Católica de Chile, Chile; K.A. Ludwig, Duke University Medical Center, Durham, NC, USA; J. Marks, The Lankenau Hospital and Institute for Medical Research, Wynnewood, PA, USA; A.J. Megibow, New York University School of Medicine, New York, NY, USA; J.I. Merlino, MetroHealth Medical Center, Cleveland, OH, USA; J.R. Monson, University of Hull and Castle Hill Hospital, Hull, East Yorkshire, UK; R.W. Motson, Colchester General Hospital, Turner Road, Colchester, UK; D.A. Nakamoto, University Hospitals of Cleveland, Cleveland, OH, USA; G.L. Newstead, Sydney Colorectal Associates, Prince of Wales Private Hospital, New South Wales, Australia; P.R. O’Connell, Mater Misericordiae University Hospital, Dublin, Ireland; Y. Panis, Beaujon Hospital, Clichy-Paris, France; F. Penninckx, University Clinic Gasthuisberg, Leuven, Belgium; A. Rajput, Roswell Park Cancer Institute, State University of New York at Buffalo, Buffalo, NY, USA; F. Seow Choen, Mt. Elizabeth Medical Centre, Singapore; M.J. Stamos, University of California, Irvine School of Medicine, Orange, CA, USA; A. Vignali, San Raffaele University Vita-Salute, Milan, Italy; S.D. Wexner, Cleveland Clinic Florida, Weston, FL, USA; K.S. Wong, National University Hospital Singapore, Yong Loo Lin School of Medicine, Singapore
Author information
Authors and Affiliations
Consortia
Corresponding author
Rights and permissions
About this article
Cite this article
Phitayakorn, R., Delaney, C.P., Reynolds, H.L. et al. Standardized Algorithms for Management of Anastomotic Leaks and Related Abdominal and Pelvic Abscesses After Colorectal Surgery. World J Surg 32, 1147–1156 (2008). https://doi.org/10.1007/s00268-008-9468-1
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00268-008-9468-1