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Metastasis suppressors in breast cancers: mechanistic insights and clinical potential

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Abstract

For the most part, normal epithelial cells do not disseminate to other parts of the body and proliferate, as do metastatic cells. Presumably, a class of molecules—termed metastasis suppressors—are involved in this homeostatic control. Metastasis suppressors are, by definition, cellular factors that, when re-expressed in metastatic cells, functionally inhibit metastasis without significantly inhibiting tumor growth. In this brief review, we catalog known metastasis suppressors, what is known about their mechanism(s) of action, and experimental and clinical associations to date.

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Acknowledgments

Work from the authors’ laboratory has been generously supported by grants from US National Cancer Institute RO1-CA134981 (DRW), Susan G. Komen for the Cure SAC11037 (DRW), National Foundation for Cancer Research-Center for Metastasis Research (DRW), and partial support from the Kansas Bioscience Authority (DRW), RO1-CA87728 (DRW), and P30-CA168524 (DRW). DRW is the Hall Family Foundation Professor of Molecular Medicine and a Kansas Bioscience Authority Eminent Scholar.

Conflict of interest

The authors have no conflicts to declare.

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Authors and Affiliations

  1. Department of Cancer Biology, The University of Kansas Medical Center, Kansas City, KS, 66160, USA

    Christopher R. Bohl, Sitaram Harihar, Warren L. Denning, Rahul Sharma & Danny R. Welch

  2. University of Kansas Cancer Center and National Foundation for Cancer Research—Center for Metastasis Research, The University of Kansas Cancer Center, Kansas City, KS, 66160,, USA

    Danny R. Welch

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  1. Christopher R. Bohl
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  2. Sitaram Harihar
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  4. Rahul Sharma
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Correspondence to Danny R. Welch.

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Christopher R. Bohl, Sitaram Harihar, and Warren Denning contributed equally to this manuscript.

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Bohl, C.R., Harihar, S., Denning, W.L. et al. Metastasis suppressors in breast cancers: mechanistic insights and clinical potential. J Mol Med 92, 13–30 (2014). https://doi.org/10.1007/s00109-013-1109-y

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  • DOI: https://doi.org/10.1007/s00109-013-1109-y

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