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Metastasis suppressor genes and their role in the tumor microenvironment

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Abstract

The metastatic cascade is a complex process with multiple factors contributing to the seeding and growth of cancer cells at metastatic sites. Within this complex process, several genes have been identified as metastasis suppressors, playing a role in the inhibition of metastasis. Interestingly, some of these genes have been shown to also play a role in regulating the tumor microenvironment. In this review, we comment on the recent developments in the biology of metastasis suppressor genes and their crosstalk with the microenvironment.

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Acknowledgements

We would like to thank Swagata Basu for critical reading and editing of the manuscript.

Funding

This work was supported by an NCI R01 (CA244780), NCI R03 (CA270679), NCI R61 (CA278402) the Irma T. Hirschl Trust, the Emerging Leader Award from the Mark Foundation (to J.J.B.C), and the Tisch Cancer Institute NIH Cancer Center grant (P30 CA196521). C.M. received support from the Ramon Areces Foundation.

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Authors and Affiliations

  1. Department of Medicine, Division of Hematology and Oncology, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Cristina Megino-Luque & Jose Javier Bravo-Cordero

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  1. Cristina Megino-Luque
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  2. Jose Javier Bravo-Cordero
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CM and JJBC wrote and edit the manuscript. CM made the figures.

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Correspondence to Jose Javier Bravo-Cordero.

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Megino-Luque, C., Bravo-Cordero, J.J. Metastasis suppressor genes and their role in the tumor microenvironment. Cancer Metastasis Rev 42, 1147–1154 (2023). https://doi.org/10.1007/s10555-023-10155-6

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