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A perspective on the metastasis suppressor field

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Abstract

Metastasis is the leading cause of cancer patient mortality. Metastasis suppressors are genes that, upon reexpression in metastatic tumor cells to levels observed in their nonmetastatic counterparts, significantly reduce metastasis without affecting the growth of the primary tumor. Analysis of > 30 metastasis suppressors revealed complex mechanisms of action that include multiple signaling pathways, transcriptional patterns, posttranscriptional regulatory mechanisms, and potential contributions of genomic stability. Clinical testing of strategies to re-establish a validated metastasis suppressor pathway in tumors is best directed to the adjuvant setting, with the goal of inhibiting the outgrowth of occult micrometastases.

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Authors and Affiliations

  1. Women’s Malignancies Branch, Center for Cancer Research, National Cancer Institute, Building 37, Room 1126, NCI, NIH, Bethesda, MD, 20892, USA

    Imran Khan & Patricia S. Steeg

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  1. Imran Khan
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  2. Patricia S. Steeg
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Correspondence to Patricia S. Steeg.

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Khan, I., Steeg, P.S. A perspective on the metastasis suppressor field. Cancer Metastasis Rev 42, 1061–1063 (2023). https://doi.org/10.1007/s10555-023-10131-0

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  • DOI: https://doi.org/10.1007/s10555-023-10131-0

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