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Reduced expression of Raf kinase inhibitor protein correlates with poor prognosis in pancreatic cancer

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Abstract

Aim

Raf kinase inhibitory protein (RKIP) is an inhibitor of the Raf/MEK/MAP kinase signaling cascade and a suppressor of cancer metastasis. But its function in pancreatic cancer was not yet clarified completely. The aim of this study was to investigate the involvement of RKIP in pancreatic cancer.

Methods

RKIP expression was investigated retrospectively by immunohistochemistry in paraffin-embedded primary tumor tissue samples from a series (n = 99) of consecutive patients with pancreatic cancer. Survival was calculated using Kaplan–Meier curves. Parameters found to be of prognostic significance in univariate analysis were verified in a multivariate Cox regression model.

Results

RKIP expression was high in normal pancreatic epithelium and retained to varying degrees in pancreatic cancer tissues. However, in tumor tissues with lymph node metastasis (P = 0.008) and high UICC stage (P = 0.006), RKIP expression was highly significantly reduced or lost. Furthermore, the reduced expression of RKIP significantly correlated with both poor overall and disease-free survival (P = 0.008 and 0.01, respectively). Multivariate analyses revealed RKIP to be an independent prognosticator.

Conclusion

These findings suggest that RKIP could be a promising marker for predicting a better prognosis in pancreatic cancer.

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Authors and Affiliations

  1. National Hepatobiliary and Enteric Surgery Research Center, Xiangya Hospital, Central South University, Xiangya Road 87, Changsha, Hunan, China

    Shi-peng Song, Sheng-bin Zhang, Zhe-hai Li, Bing Li, Qian-de Liao & Yang-de Zhang

  2. Department of Genery Surgery, The Third Affiliated Hospital of Inner Mongolia Medical College (Baogang Hospital of Inner Mongolia), Shaoxian Road 20, Kun District, Baotou, Inner Mongolia

    Shi-peng Song, Sheng-bin Zhang & Yong-sheng Zhou

  3. Department of Genery Surgery, The Hospital of Jiuyuan Baotou, Shahe Street 31, Jiuyuan District, Baotou, Inner Mongolia

    Zhan-wei Bian

Authors
  1. Shi-peng Song
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  2. Sheng-bin Zhang
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  3. Zhe-hai Li
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  4. Yong-sheng Zhou
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  5. Bing Li
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  6. Zhan-wei Bian
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  7. Qian-de Liao
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  8. Yang-de Zhang
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Corresponding author

Correspondence to Yang-de Zhang.

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Song, Sp., Zhang, Sb., Li, Zh. et al. Reduced expression of Raf kinase inhibitor protein correlates with poor prognosis in pancreatic cancer. Clin Transl Oncol 14, 848–852 (2012). https://doi.org/10.1007/s12094-012-0870-7

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  • DOI: https://doi.org/10.1007/s12094-012-0870-7

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