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To be or not to be: PP2A as a dual player in CNS functions, its role in neurodegeneration, and its interaction with brain insulin signaling

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Abstract

Accumulating evidence has reached the consensus that the balance of phosphorylation state of signaling molecules is a pivotal point in the regulation of cell signaling. Therefore, characterizing elements (kinases–phosphatases) in the phosphorylation balance are at great importance. However, the role of phosphatase enzymes is less investigated than kinase enzymes. PP2A is a member of serine/threonine protein phosphatase that its imbalance has been reported in neurodegenerative diseases. Therefore, we reviewed the superfamily of phosphatases and more specifically PP2A, its regulation, and physiological functions participate in CNS. Thereafter, we discussed the latest findings about PP2A dysregulation in Alzheimer and Parkinson diseases and possible interplay between this phosphatase and insulin signaling pathways. Finally, activating/inhibitory modulators for PP2A activity as well as experimental methods for PP2A study have been reviewed.

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Acknowledgements

The authors are thankful to neuroscience research center and neurophysiology research center Shahid Beheshti University of Medical science for supporting this work.

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  1. Department of Physiology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Pegah Javadpour & Rasoul Ghasemi

  2. Neurobiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Leila Dargahi

  3. Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Abolhassan Ahmadiani

  4. Neurophysiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Rasoul Ghasemi

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  1. Pegah Javadpour
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Javadpour, P., Dargahi, L., Ahmadiani, A. et al. To be or not to be: PP2A as a dual player in CNS functions, its role in neurodegeneration, and its interaction with brain insulin signaling. Cell. Mol. Life Sci. 76, 2277–2297 (2019). https://doi.org/10.1007/s00018-019-03063-y

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  • DOI: https://doi.org/10.1007/s00018-019-03063-y

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