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The role of serine/threonine protein phosphatase type 5 (PP5) in the regulation of stress-induced signaling networks and cancer

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Abstract

Although the aberrant actions of protein kinases have long been known to contribute to tumor promotion and carcinogenesis, roles for protein phosphatases in the development of human cancer have only emerged in the last decade. In this review, we discuss the data obtained from studies examining the biological and pathological roles of a serine/threonine protein phosphatase, PP5, which suggest that PP5 is a potentially important regulator of both hormone- and stress-induced signaling networks that enable a cell to respond appropriately to genomic stress.

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Abbreviations

ASK1:

apoptosis signal-regulating kinase 1

ATM:

ataxia-telangiectasia mutated kinase

ATR:

ATM and Rad 3 related kinase

DNA-PKcs:

DNA-dependent Ser/Thr protein kinase

EGF:

epidermal growth factor

ER:

estrogen receptor

ERK:

extracellular signal-regulated kinase1/mitogen-activated protein kinase 1

FKBP51:

51kDa FK506-binding protein

FKBP52:

52kDa FK506-binding protein

GR:

glucocorticoid receptor

HIF-1:

hypoxia inducible factor-1

Hsp-90:

heat shock protein 90

Mdm2:

p53-murine double minute 2 Ub E3 ligase

MEK:

MAP/ERK kinase 1

p53:

p53 tumor suppressor protein

PP1:

serine/threonine protein phosphatase type 1

PP2A:

serine/threonine protein phosphatase type 2A

PP2B:

serine/threonine protein phosphatase type 2B/calcinurin

PP4:

serine/threonine protein phosphatase type 4

PP5:

serine/threonine protein phosphatase type 5

PP6:

serine/threonine protein phosphatase type 6

PP7:

serine/threonine protein phosphatase type 7

PPAR:

peroxisome proliferator activated receptors

PPase:

serine/threonine protein phosphatase

Rac:

Rac GTP-binding protein

Raf-1:

Raf proto-oncogene serine/threonine protein kinase

Rho:

Rho GTP-binding protein

TPR:

tetratricopeptide repeat

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Acknowledgements

This work was supported in part by grants from the National Institutes of Health (NCI grant CA-60750 to REH), the National Center for Research Resources, a component of NIH (NCRR P2PRR016478 to TG).

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Authors and Affiliations

  1. Department of Biological Sciences, Southeastern Oklahoma State University, 1405 N. 4th Ave., PMB 4087, Durant, OK, 74701, USA

    Teresa Golden

  2. Department of Biochemistry and Molecular Biology, MSB 2362, University of South Alabama, Mobile, AL, 36688, USA

    Mark Swingle & Richard E. Honkanen

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  1. Teresa Golden
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Golden, T., Swingle, M. & Honkanen, R.E. The role of serine/threonine protein phosphatase type 5 (PP5) in the regulation of stress-induced signaling networks and cancer. Cancer Metastasis Rev 27, 169–178 (2008). https://doi.org/10.1007/s10555-008-9125-z

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