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Seasonal variation in peripheral blood leukocyte subsets and in serum interleukin-6, and soluble interleukin-2 and-6 receptor concentrations in normal volunteers

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Abstract

This study has been carried out in order to investigate seasonal variation in peripheral blood immune cells, such as leukocytes, monocytes, neutrophils, lymphocytes, CD3+ T, CD4+ T, CD8+ t, CD25+ T, CD20+ B, and serum interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6R) and sIL-2R levels in normal volunteers. Toward this end, 26 normal volunteers (13 men, 13 women) had monthly blood samplings during one calendar year for peripheral blood count, flow cytometric enumeration of peripheral leukocyte subsets and immunoassays of IL-6, sIL-6R and sIL-2R. It was found that most of the immune variables change rhythmically during the seasons as a group phenomenon. Statistically significant yearly variations with seasonal rhythms, i.e. annual rhythms or harmonics, such as semiannual, tetramensual and trimensual rhythms, were found in the number of leukocytes, neutrophils, monocytes, lymphocytes, CD4+ T, CD8+ T, CD25+ T, CD20+ B cells, in the CD4+/CD8+ ratio, and serum IL-6 and sIL-6R levels. It is concluded that the immune system is characterized by a multifrequency time-structure with significant high-amplitude yearly variations in the number of some peripheral blood leukocyte subsets.

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References

  1. Goulding, N. J., and Hall, N. D., Pharmac. Ther.58 (1994) 249.

    Article  Google Scholar 

  2. Haus, E., in: Biologic Rhythms in Clinical and Laboratory Medicine, p. 504. Eds Y. Touitou and E. Haus. Springer Verlag, New York 1992.

    Chapter  Google Scholar 

  3. Haus, E., Lakatua, D., Swoyer, J., and Sackett-Lundeen, L., Am. J. Anat.168 (1983) 467.

    Article  CAS  PubMed  Google Scholar 

  4. Fernandes, G., in: Biologic Rhythms in Clinical and Laboratory Medicine, p. 493. Eds Y. Touitou and E. Haus. Springer Verlag, New York 1992.

    Chapter  Google Scholar 

  5. Smaaland, R., and Laerum, O. D., in: Biologic Rhythms in Clinical and Laboratory Medicine, p. 527. Eds Y. Touitou and E. Haus. Springer Verlag New York 1992.

    Chapter  Google Scholar 

  6. Bureau, J. P., and Garrelly, L., in: Biologic Rhythms in Clinical and Laboratory Medicine, p. 547. Eds Y. Touitou and E. Haus. Springer Verlag, New York 1992.

    Chapter  Google Scholar 

  7. Reinberg, A., and Smolensky, M., in: Biological Rhythms and Medicine. Cellular, Metabolic, Physiopathologic and Pharmacologic Aspects. Springer, Berlin-Heidelberg-New York 1983.

    Chapter  Google Scholar 

  8. Reinberg, A., Schuller, E., Delasnerie, N., Clench, J., and Helary, M., Nouv. Presse med.6 (1977) 3819.

    CAS  PubMed  Google Scholar 

  9. Reinberg, A., Schuller, E., Clench, J., and Smolensky, M. H., in: Recent Advances in the Chronobiology of Allergy and Immunology, p. 251. Ed. M. H. Smolensky. Pergamon Press, New York 1980.

    Google Scholar 

  10. Gidlow, D. A., Ann. clin. Biochem.20 (1983) 341.

    Article  CAS  PubMed  Google Scholar 

  11. Tromp, S. W., Medical Biometeorology. Elsevier, Amsterdam 1963.

    Google Scholar 

  12. Rocker, L., Feddersen, H. M., Hoffmeister, H., and Junge, B., Klin. Wschr.58 (1980) 769.

    Article  CAS  PubMed  Google Scholar 

  13. Bratescu, A., and Teodorescu, M., J. Allergy clin. Immun.68 (1981) 273.

    Article  CAS  PubMed  Google Scholar 

  14. Lévi, F., Canon, C., Touitou, Y., Reinberg, A., and Mathé, G., J. clin. Invest.81 (1988) 407.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Abo, T., and Kumagai, K., Clin. expl Immun.33 (1978) 441.

    CAS  Google Scholar 

  16. MacMurray, J. P., Barker, J. P., Armstrong, J. D., Bozzetti, L. P., and Kuhn, I. N., Life Sci.32 (1983) 2363.

    Article  CAS  PubMed  Google Scholar 

  17. Lévi, F., and Halberg, F., L Ric. clin. lab.12 (1982) 323.

    Article  Google Scholar 

  18. Shifrine, M., Garsd, A., and Rosenblatt, L. S., J. Interdiscipl. Cycle Res.13 (1982) 157.

    Article  Google Scholar 

  19. Pati, A. K., Florentin, I., Chung, V., DeSousa, M., Lévi, F., and Mathe, G., Cell. Immun.108 (1987) 227.

    Article  CAS  Google Scholar 

  20. Brock, M. A., J. Immun.130 (1983) 2686.

    Article  Google Scholar 

  21. Canon, C., and Lévi, F., in: Biologic Rhythms in Clinical and Laboratory Medicine, p. 635. Eds. Y. Toutiou and E. Haus. Springer Verlag, New York 1992.

    Chapter  Google Scholar 

  22. Labrecque, G., in: Biologic Rhythms in Clinical and Laboratory Medicine, p. 483. Eds Y. Toutiou and E. Haus. Springer Verlag, New York 1992.

    Chapter  Google Scholar 

  23. Cohen, P., Wax, Y., and Modan, B., Cancer Res.43 (1983) 892.

    CAS  PubMed  Google Scholar 

  24. Langlands, A. O., Simpson, H., Sothern, R. B., and Halberg, F., in: Proceedings of the 8th International Scientific Meeting of the International Epidemiological Association, p. 17. Int. Epidemiol. Ass. San Juan, Puerto Rico 1977.

    Google Scholar 

  25. Hrushesky, W. J. M., Haus, E., Lakatua, D., Vogelzang, N., and Kennedy, B. J., Proc. Am. Soc. clin. Oncol.24 (1983) 18.

    Google Scholar 

  26. Hrushesky, W. J. M., and Marz, W. J., in: Biologic Rhythms in Clinical and Laboratory Medicine, p. 611. Eds Y. Toutiou and E. Haus. Springer Verlag, New York 1992.

    Chapter  Google Scholar 

  27. De Meyer, F., and Vogelaere, P., Int. J. Biometeor.34 (1991) 105.

    Article  Google Scholar 

  28. Maes, M., Cosyns, P., Meltzer, H. Y., DeMyer, F., and Peeters, D., Am. J. Psychiatr.150 (1993) 1380.

    Article  CAS  PubMed  Google Scholar 

  29. Maes, M., De Meyer, F., Peeters, D., Meltzer, H. Y., Schotte, C., Scharpe, S., and Cosyns, P., Int. J. Biometeor.37 (1993) 78.

    Article  CAS  Google Scholar 

  30. American Psychiatric Association, Diagnostic and Statistical Manual of Mental Disorders, 3rd edn, revised. American Psychiatric Association, Washington, DC, 1987.

    Google Scholar 

  31. Spitzer, R. L., Williams, J. B. W., Gibbon, M. S. W., and First, M. B., Structured Clinical Interview according to DSM-III-R. American Psychiatric Press, Inc., Washington, DC 1990.

    Google Scholar 

  32. Blackman, R. B., and Tukey, J. W., in: The Measurement of Power Spectra. Dover, New York 1959.

    Google Scholar 

  33. Vanicěk, P., Astrophys. Space Sci.4 (1969) 387.

    Article  Google Scholar 

  34. Bingham, C., Arbogast, B., Cornelissen, G., Lee, J. K., and Halberg, F., Chronobiology9 (1982) 397.

    CAS  Google Scholar 

  35. Nelson, W., Tong, Y. L., Lee, J., and Halberg, F., Chronobiology6 (1979) 305.

    CAS  Google Scholar 

  36. Ostrom, C. W., The Timpe Series Analysis: Regression Techniques, Eds J. L. Sullivan and R. G. Niemi. Sage Publications, London 1980.

    Google Scholar 

  37. Haus, E., and Toutiou, Y., in: Biologic Rhythms in Clinical and Laboratory Medicine, p. 673. Eds Y. Touitou and E. Haus. Springer Verlag, Berlin 1992.

    Chapter  Google Scholar 

  38. Fraser, C. G., and Harris, E. K., Crit. Rev. clin. lab. Sci.27 (1989) 409.

    Article  CAS  PubMed  Google Scholar 

  39. Fraser, C. G., in: Interpretation of Clinical Chemistry Laboratory Data, p. 111. Ed. C. G. Fraser. Blackwell Scientific Publications, Oxford 1986.

    Google Scholar 

  40. Harris, E. K., Prog. clin. Path.8 (1981) 45.

    CAS  Google Scholar 

  41. Libeer, J.-P., External Quality Assessments in Clinical Laboratories: European Perspectives, Today and Tommorow. Doctoral Thesis, University of Antwerp 1993.

  42. Arendt, J., in: Biologic Rhythms in Clinical and Laboratory Medicine, p. 348. Eds Y. Toutiou and E. Haus. Springer Verlag, New York 1992.

    Chapter  Google Scholar 

  43. Ratajczak, H. V., Thomas, P. T., Sothern, R. B., Vollmuth, T., and Heck, J. D., Chronobiol. Int.10 (1993) 383.

    Article  CAS  PubMed  Google Scholar 

  44. Brainard, G., Knobler, R. L., Podolin, P. L., Lavasa, M., and Lublin, F. D., Life Sci.40 (1987) 1319

    Article  CAS  PubMed  Google Scholar 

  45. Vetvicka, V., Holub, M., and Houstek, J., APMIS101 (1993) 113.

    Article  CAS  PubMed  Google Scholar 

  46. Vetvicka, V., Holub, M., and Houstek, J., Thymus21 (1993) 11.

    CAS  PubMed  Google Scholar 

  47. Roemeling, R. von, in: Biologic Rhythms in Clinical and Laboratory Medicine, p. 600. Eds Y. Touitou and E. Haus. Springer Verlag, New York 1992.

    Chapter  Google Scholar 

  48. Agrimonti, F., Angeli, A., Frairia, R., Fazzari, A. M., Tamagnone, C., Fornaro, D., and Ceresa, F., Chronobiology9 (1982) 107.

    CAS  Google Scholar 

  49. Arendt, J., Wirz-Justice, A., Bradtke, A., Neurosci. Lett.7 (1977) 327.

    Article  Google Scholar 

  50. Gatti, G., Angeli, A., and Carignola, R., in: Biological Rhythms in Clinical Laboratory Medicine, p. 363. Eds Y. Touitou and E. Haus. Springer Verlag, New York 1992.

    Chapter  Google Scholar 

  51. Solensky, M. H., and Sargent, F. S., in: Advances in Climatic Physiology, p. 281. Eds S. Itoh, K. Ogata and H. Yoshimura. Igaku Shoin, Tokyo 1972.

    Chapter  Google Scholar 

  52. Smolensky, M. H., in: Biologic Rhythms in Clinical Laboratory Medicine, p. 658. Y. Touitou and E. Haus. Springer Verlag, New York 1992.

    Chapter  Google Scholar 

  53. Smolensky, M. H., in: Biological Rhythms and Medicine, p. 131. Eds A. Reinberg and M. H. Smolensky. Springer Verlag, New York 1983.

    Chapter  Google Scholar 

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Author notes

  1. M. Maes

    Present address: Department of Psychiatry, University Hospital of Cleveland, School of Medicine, Hanna Pavilion, Room B-68, 2040 Abington Road, 44106, Cleveland, OH, USA

Authors and Affiliations

  1. Department of Psychiatry, Case Western Reserve University, Cleveland, Ohio, USA

    P. Thompson

  2. Department of Immunology, University of Antwerp, Wilrijk, Belgium

    W. Stevens, L. De Clerck & C. Bridts

  3. Department of Medical Biochemistry, University of Antwerp, Wilrijk, Belgium

    S. Scharpe

  4. Eurogenetics, Tessenderlo, Belgium

    E. Bosmans

  5. Department of Geophysics, Royal Meterological Institute, Brussels, Belgium

    F. De Meyer

  6. Department of Psychiatry, University Hospital of Antwerp, Edegem, Belgium

    P. D'Hondt, D. Peeters & P. Cosyns

  7. Laboratory of Clinical Biology, Middelheim Ziekenhuis, Antwerp, Belgium

    H. Neels & A. Wauters

  8. Laboratory of Clinical Biology, St-Augustinus Ziekenhuis, Antwerp, Belgium

    W. Cooreman

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Maes, M., Stevens, W., Scharpe, S. et al. Seasonal variation in peripheral blood leukocyte subsets and in serum interleukin-6, and soluble interleukin-2 and-6 receptor concentrations in normal volunteers. Experientia 50, 821–829 (1994). https://doi.org/10.1007/BF01956463

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