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Jahreszeitliche Veränderungen diagnostisch wichtiger Blutbestandteile

Seasonal variation of blood components important for diagnosis

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Summary

In a comparative study, the differences between the values measured for 26 blood and serum components in both winter and summer were determined in 78 healthy subjects. Comparable conditions during the preparation of test persons, sampling, processing of specimens, and measurement were strictly observed. The term “season” is defined more precisely by meteorological data.

In the summer season, significantly higher values were found for leukocytes (9%), lactate dehydrogenase and MCHC (7% each), creatinine (7%, in women only), and MCH (1%) whereas significantly lower values were exhibited by aspartate aminotransferase (18%), alanine aminotransferase (14%), alkaline phosphatase (11%), glucose and packed cell volume (7% each), MCV (6%), total protein (2%), erythrocytes, albumin, sodium and chloride (1% each). These partly considerable alterations should be taken into account in the establishment of reference values and evaluation of laboratory findings (above all, when intraindividual comparison is involved). There were no significant alterations of the following parameters: hemoglobin, γ-glutamyl transferase, urea, uric acid, creatinine (men only), bilirubin, cholesterol, total glycerol, potassium, calcium, and inorganic phosphate.

In another series of experiments involving 32 test persons, the influence of different ambient temperatures during blood sampling on the above mentioned blood components was studied. Within the 18–30° C range, no significant alterations were detected.

Zusammenfassung

Bei 78 gesunden Männern und Frauen wurden Differenzmessungen zwischen Winter und Sommer für 26 Blut- und Serumbestandteile durchgeführt. Vergleichbare Bedingungen bei der Patientenvorbereitung, Probennahme, Probenverarbeitung und Messung wurden streng eingehalten. Der Begriff „Jahreszeit“ ist durch meteorologische Daten differenzierter beschrieben. Signifikanthöhere Werte fanden sich im Sommer bei Leukozyten (9%), Laktatdehydrogenase und MCHC (je 7%), Kreatinin (nur bei Frauen 7%), MCH (1%). Im Sommer signifikantniedrigere Werte als im Winter zeigten Aspartataminotransferase (18%), Alaninaminotransferase (14%), alkalische Phosphatase (11%), Glukose und Zellpakkungsvolumen (je 7%), MCV (6%), Gesamteiwei\ (2%), Erythrozyten, Albumin, Natrium und Chlorid (je 1%). Diese zum Teil erheblichen Veränderungen müssen bei der Aufstellung von Referenzwerten und bei der Beurteilung von Laboratoriumsbefunden — besonders im intraindividuellen Vergleich — berücksichtigt werden. Keine signifikanten Veränderungen ergaben sich bei Hämoglobin, γ-Glutamyltransferase, Harnstoff, Harnsäure, Kreatinin (nur bei Männern), Bilirubin, Cholesterin, Gesamtglycerin, Kalium, Calcium, anorganischem Phosphat.

In einem weiteren Versuch an 32 Probanden wurde der Einfluß verschiedener Umgebungstemperaturen bei der Blutentnahme auf dieselben Blut- und Serumbestandteile geprüft. Im Bereich von 18–30° C traten keine bedeutsamen Veränderungen auf.

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Authors and Affiliations

  1. Physiologisches Institut der Freien Universität Berlin, Germany

    L. Röcker, H. -M. Feddersen,  H. Hoffmeister & B. Junge

  2. Leistungszentrum Berlin (Sportmedizin), Germany

    L. Röcker, H. -M. Feddersen,  H. Hoffmeister & B. Junge

  3. Institut für Sozialmedizin und Epidemiologie des Bundesgesundheitsamtes Berlin, Germany

    L. Röcker, H. -M. Feddersen,  H. Hoffmeister & B. Junge

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  1. L. Röcker
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  2. H. -M. Feddersen
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  3. H. Hoffmeister
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  4. B. Junge
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Herrn Prof. Dr. Harald Mellerowicz zum 60. Geburtstag gewidmet.

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Röcker, L., Feddersen, H.M., Hoffmeister, H. et al. Jahreszeitliche Veränderungen diagnostisch wichtiger Blutbestandteile. Klin Wochenschr 58, 769–778 (1980). https://doi.org/10.1007/BF01478285

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  • DOI: https://doi.org/10.1007/BF01478285

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