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Inflammatory Reaction and Disease States

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Biologic Rhythms in Clinical and Laboratory Medicine

Abstract

Clinicians are well aware that the signs and symptoms of rheumatoid arthritis (RA) and osteoarthritis (OA) vary within days and between days. The classic morning stiffness observed in patients with RA is so characteristic that it has become one of the diagnostic criteria of the disease [1]. In the last decade, the circadian and circannual variability in inflammatory and arthritic diseases has been confirmed by clinical studies, and important time-dependent variations have been demonstrated, including the desirable and undesirable side effects of nonsteroidal anti-inflammatory drugs (NSAID). The concepts and principles of chronopharmacology can now be used to optimize the efficacy of NSAID in patients suffering from arthritis, but most physicians must familiarize themselves with this new approach in drug treatment.

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Authors
  1. G. Labrecque
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Editors and Affiliations

  1. Faculté de Médecine Pitié-Salpétrière, Laboratoire de Biochimie Médicale, 91, Boulevard de l’Hôpital, 75634, Paris Cedex 13, France

    Yvan Touitou (Professor of Biochemistry) (Professor of Biochemistry)

  2. Department of Laboratory Medicine and Pathology, University of Minnesota, 640 Jackson Street, 55101-259, St.Paul, MN, USA

    Erhard Haus (Professor, Chairman) (Professor, Chairman)

  3. Department of Anatomic and Clinical Pathology, St. Paul-Ramsey Medical Center, 640 Jackson Street, 55101-259, St.Paul, MN, USA

    Erhard Haus (Professor, Chairman) (Professor, Chairman)

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© 1992 Springer-Verlag Berlin Heidelberg

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Labrecque, G. (1992). Inflammatory Reaction and Disease States. In: Touitou, Y., Haus, E. (eds) Biologic Rhythms in Clinical and Laboratory Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78734-8_35

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  • DOI: https://doi.org/10.1007/978-3-642-78734-8_35

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78736-2

  • Online ISBN: 978-3-642-78734-8

  • eBook Packages: Springer Book Archive

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