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“Negative Inotropic Cascades” in Cardiomyocytes Triggered by Substances Relevant to Sepsis

  • Chapter
Pathophysiology of Shock, Sepsis, and Organ Failure

Abstract

In animal experiments as well as in studies with isolated heart preparations, direct effects of bacterial toxins and sepsis mediators on heart function interfere with indirect ones and are often difficult to discern; primary effects on the coronary circulation and stimulation of local mediator cells often superimpose direct negative inotropic and cytotoxic effects of toxins and mediators in the heart. Although the methodological limitations are conspicuous, experiments with isolated heart muscle cells may circumvent many of these problems and represent a suitable model to study direct cardiodepressive effects of these substances.

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  1. Department of Medicine I, Klinikum Grosshadern, University of München, 8000, München, Germany

    K. Werdan, U. Müller & C. Reithmann

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  2. U. Müller
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  1. Ludwig-Boltzmann Institute for Experimental and Clinical Traumatology, Donaueschingenstraße 13, A-1200, Vienna, Austria

    Günther Schlag M. D.  & Heinz Redl Ph. D.  & 

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Werdan, K., Müller, U., Reithmann, C. (1993). “Negative Inotropic Cascades” in Cardiomyocytes Triggered by Substances Relevant to Sepsis. In: Schlag, G., Redl, H. (eds) Pathophysiology of Shock, Sepsis, and Organ Failure. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76736-4_55

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