Skip to main content
SpringerLink
Log in

Effect of platelet activating factor on guinea-pig papillary muscle

  • Short Communications
  • Physiology, Pathophysiology
  • Published:
Experientia Aims and scope Submit manuscript

Summary

Platelet activating factor (PAF) induces a biphasic effect on guinea-pig papillary muscle: 1. a transient positive inotropic effect preceded by an increase in action potential duration (APD); 2. a marked negative effect on inotropism and on APD. Since Ca++ slow action potentials were initially enhanced by PAF and then markedly depressed, it is suggested that PAF specifically interferes with the Ca++ slow channel.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Benveniste, J., Henson, P.M., and Cochrane, C.G., J. exp. Med.136 (1972) 1356.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Benveniste, J., Tencé, M., Bidault, J., Boullet, C., and Polonsky, J. C.r. acad. Sci. Paris289 (1979) 1037.

    CAS  Google Scholar 

  3. Demopoulos, C.A., Pinckard, R.N., and Hanahan, D.J., J. biol. Chem.254 (1979) 9355.

    Article  CAS  PubMed  Google Scholar 

  4. Camussi, G., Aglietta, M., Coda, R., Bussolino, F., Piacibello, W., and Tetta, C., Immunology42 (1981) 191.

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Mencia-Huerta, J.M., and Benveniste, J., Eur. J. Immun.9 (1979) 409.

    Article  CAS  Google Scholar 

  6. Chignard, M., Le Couedic, J.P., Tencé, M., Vargafting, B.B., and Benveniste, J., Br. J. Hemat.46 (1980) 455.

    Article  CAS  Google Scholar 

  7. Camussi, G., Aglietta, M., Malavasi, F., Tetta, C., Piacibello, W., Sanavio, F., and Bussolino, F., J. Immun.131 (1983) 2397.

    Article  CAS  PubMed  Google Scholar 

  8. Pinckard, R.N., Farr, R.S., and Hanahan, D.J., J. Immun.123 (1983) 1847.

    Article  Google Scholar 

  9. Camussi, G., Tetta, C., Deregibus, M.C., Bussolino, F., Segoloni, G., and Vercellone, A., J. Immun.128 (1982) 86.

    Article  CAS  PubMed  Google Scholar 

  10. Pinckard, R.N. in: Current topics in inflammation and infection, p. 38. Eds. G. Majno and R.S. Cotran. Williams and Wilkins, Baltimore 1982.

    Google Scholar 

  11. Findlay, S.R., Lichtenstein, L.M., Hanahan, D.J., and Pinckard, R.N., Am. J. Physiol.241 (1981) 130.

    Article  Google Scholar 

  12. Halonen, M., Palmer, J.D., Lohman, C., McManus, L., and Pickard, R.N., Am. Rev. Resp. Dis.122 (1980) 915.

    CAS  PubMed  Google Scholar 

  13. Burke, J.A., Levi, R., Hanahan, D.J., and Pinckard, R.N., Fedn Proc.41 (1982) 3235.

    Google Scholar 

  14. Cedrini, L., Camino, E., Alloatti, G., Cantino, D., and Botto Micca, F., J. Physiol.77 (1981) 861.

    CAS  Google Scholar 

  15. Benveniste, J., Le Couedic, J.P., Polonsky, J., and Tencé, M., Nature269 (1977) 170.

    Article  CAS  PubMed  Google Scholar 

  16. Fleckenstein, A., in: New Perspective on Calcium Antagonists. Ed. G. B. Weiss, Am. Physiol. Soc., Bethesda, Maryland 1981.

    Google Scholar 

  17. Lee, T.C., Malone, B., Blank, M.L., and Snyder, F., Biochem. biophys. Res. Commun.102 (1981) 1262.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Author notes

  1. G. Alloatti & M. Meda

    Present address: Istituto di Fisiologia Generale, Università degli Studi di Torino, Torino, Italy

Authors and Affiliations

  1. Laboratorio di Immunopatologia, Ospedale di S. Giovanni Battista e della Città di Torino, Torino, Italy

    G. Camussi,  G. Alloatti, G. Montrucchio, M. Meda & G. Emanuelli

Authors
  1. G. Camussi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. Alloatti
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G. Montrucchio
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. Meda
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. G. Emanuelli
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Camussi, G., Alloatti, G., Montrucchio, G. et al. Effect of platelet activating factor on guinea-pig papillary muscle. Experientia 40, 697–699 (1984). https://doi.org/10.1007/BF01949729

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01949729

Keywords

Search

Navigation