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Astroglial Serotonin Receptors as the Central Target of Classic Antidepressants

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Astrocytes in Psychiatric Disorders

Part of the book series: Advances in Neurobiology ((NEUROBIOL,volume 26))

Abstract

Major depressive disorder (MDD) presents multiple clinical phenotypes and has complex underlying pathological mechanisms. Existing theories cannot completely explain the pathophysiological mechanism(s) of MDD, while the pharmacology of current antidepressants is far from being fully understood. Astrocytes, the homeostatic and defensive cells of the central nervous system, contribute to shaping behaviors, and regulating mood and emotions. A detailed introduction on the role of astrocytes in depressive disorders is thus required, to which this chapter is dedicated. We also focus on the interactions between classic antidepressants and serotonin receptors, overview the role of astrocytes in the pharmacological mechanisms of various antidepressants, and present astrocytes as targets for the treatment of bipolar disorder. We provide a foundation of knowledge on the role of astrocytes in depressive disorders and astroglial 5-HT2B receptors as targets for selective serotonin reuptake inhibitors in vivo and in vitro.

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Acknowledgments

BL’s work is supported by the National Natural Science Foundation of China (grant number 8187185), LiaoNing Revitalization Talents Program (grant number XLYC1807137), the Scientific Research Foundation for Returned Scholars of Education Ministry of China (grant number 20151098), LiaoNing Thousands Talents Program (grant number 202078), and “ChunHui” Program of Education Ministry of China (grant number 2020703). CS’s work is supported by a grant from the Italian Ministry of Education, University and Research (2015KP7T2Y_002) and a grant from the Sapienza University of Rome (RM11916B7A8D0225). VP’s work is supported by a grant from the National Institute of General Medical Sciences of the National Institutes of Health (R01GM123971). VP is an Honorary Professor at the University of Rijeka, Croatia.

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Authors and Affiliations

  1. Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK

    Alexei Verkhratsky

  2. Achucarro Center for Neuroscience, IKERBASQUE, Basque Foundation for Science, Bilbao, Spain

    Alexei Verkhratsky

  3. Department of Neurobiology, The University of Alabama at Birmingham, Birmingham, AL, USA

    Vladimir Parpura

  4. Department of Physiology and Pharmacology “Vittorio Erspamer”, SAPIENZA University of Rome, Rome, Italy

    Caterina Scuderi

  5. Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University, Shenyang, People’s Republic of China

    Baoman Li

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  1. Alexei Verkhratsky
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  2. Vladimir Parpura
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  4. Baoman Li
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Correspondence to Baoman Li .

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Editors and Affiliations

  1. Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University, Shenyang, China

    Baoman Li

  2. Department of Neurobiology, The University of Alabama at Birmingham, Birmingham, AL, USA

    Vladimir Parpura

  3. Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK

    Alexei Verkhratsky

  4. Department of Physiology and Pharmacology “Vittorio Erspamer”, Sapienza University of Rome, Rome, Italy

    Caterina Scuderi

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Verkhratsky, A., Parpura, V., Scuderi, C., Li, B. (2021). Astroglial Serotonin Receptors as the Central Target of Classic Antidepressants. In: Li, B., Parpura, V., Verkhratsky, A., Scuderi, C. (eds) Astrocytes in Psychiatric Disorders. Advances in Neurobiology, vol 26. Springer, Cham. https://doi.org/10.1007/978-3-030-77375-5_13

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