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Dopamine Receptor Subtypes in Reward and Relapse

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The Dopamine Receptors

Part of the book series: The Receptors ((REC))

Abstract

With the advent of subtype-selective ligands and dopamine receptor knockout mice, the last two decades have seen an explosion in research on the role of dopamine receptor subtypes in reward and relapse to drug-seeking behavior. This chapter represents a relatively comprehensive review of this literature, beginning with the ability of D1-like and D2-like receptor agonists to support self-administration behavior and produce conditioned preference, and followed by the modulation of natural reward, brain stimulation reward, and conditioned reward with subtype-selective ligands and dopamine receptor knockout mice. Subsequent sections describe the modulation of drug and alcohol self-administration by dopamine receptor subtypes, and role of dopamine receptor subtypes in relapse to drug and alcohol seeking in animal models. Finally, down-regulation in dopamine receptors following chronic drug self-administration is discussed in reference to differential changes in dopamine receptor-mediated behavior, suggesting that better integration between biological and behavioral data is needed in future studies.

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Acknowledgements

This work is supported by United States Public Health Service Grants DA 010460 and DA 018743 and by the Wesley Gilliland Professorship in Biomedical Research (UTSW).

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  1. Department of Psychiatry, The Seay Center for Basic and Applied Research in Psychiatric Illness, University of Texas Southwestern Medical Center, 75390-9070, Dallas, Texas, USA

    David W. Self

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  1. Portland VA Medical Center (R & D-30), SW. US Veterans Hospital Rd. 3710, Portland, 97239-2999, U.S.A.

    Kim A. Neve

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Self, D.W. (2010). Dopamine Receptor Subtypes in Reward and Relapse. In: Neve, K. (eds) The Dopamine Receptors. The Receptors. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60327-333-6_17

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