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Bilateral intra-accumbens self-administration ofd-amphetamine: Antagonism with intra-accumbens SCH-23390 and sulpiride

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Abstract

The efficacy ofd-amphetamine to support a selective bilateral intra-accumbens self-administration response was examined. Bilateral intra-accumbens infusions ofd-amphetamine were made contingent upon the acquisition of a lever-pressing response. Two identical levers were available within the operant chamber. Depression of the drug lever resulted in the intra-accumbens delivery of 1 µgd-amphetamine; responses upon the second, control lever were recorded but had no programmed consequences. Animals were not ‘primed’ with non-contingent infusions ofd-amphetamine at any time during these experiments. Nonetheless, animals readily acquired a selective response upon the drug lever. Removal of thed-amphetamine moiety from the infusate resulted in a large decline in responding, and the abolition of the selectivity of the response for the drug lever. Adulteration of the infusate with either the D1 dopamine receptor antagonist SCH-23390 or the D2 dopamine receptor antagonist sulpiride enhanced the rate of response selectively upon the drug lever. Reductions in the dose ofd-amphetamine also increased the rate of response. The effect of co-adulteration of the infusate with both SCH-23390 and sulpiride together was purely additive. The implications of these data for the methodology of intracranial drug self-administration, and the relationship between D1 and D2 dopamine receptors within the nucleus accumbens are discussed.

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Authors and Affiliations

  1. Department of Psychology, University of York, YOI SDD, Heslington, York, UK

    Gavin D. Phillips

  2. Department of Experimental Psychology, University of Cambridge, Downing Street, CB2 3DY, Cambridge, UK

    Trevor W. Robbins

  3. Department of Anatomy, University of Cambridge, Downing Street, CB2 3DY, Cambridge, UK

    Barry J. Everitt

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  1. Gavin D. Phillips
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  2. Trevor W. Robbins
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Phillips, G.D., Robbins, T.W. & Everitt, B.J. Bilateral intra-accumbens self-administration ofd-amphetamine: Antagonism with intra-accumbens SCH-23390 and sulpiride. Psychopharmacology 114, 477–485 (1994). https://doi.org/10.1007/BF02249339

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  • DOI: https://doi.org/10.1007/BF02249339

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