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NMDA or AMPA/kainate receptor blockade prevents acquisition of conditioned place preference induced by D2/3 dopamine receptor stimulation in rats

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Abstract

Rationale

Recent experiments from this laboratory demonstrated synergistic effects of AMPA/kainate receptor blockade and D2/3 dopamine (DA) receptor stimulation on brain stimulation reward and locomotor activity.

Objectives

Using place conditioning, this study explored further the interaction between DA and glutamate (Glu) using the N-methyl-d-aspartate (NMDA) receptor antagonist MK-801, the AMPA/kainate receptor antagonist NBQX, and the D2/3 DA receptor agonist 7-OH-DPAT.

Methods

Effects of these compounds, alone and combined, were measured in male Sprague–Dawley rats using an unbiased two-compartment place conditioning procedure.

Results

7-OH-DPAT (0.03–5.0 mg kg−1, s.c.) administered immediately prior to conditioning was ineffective; when administered 15 min prior to conditioning, only the highest dose (5.0 mg kg−1, s.c.) induced conditioned place preference (CPP). Acquisition of 7-OH-DPAT-induced CPP was blocked by MK-801 (0.06 or 0.13 mg kg−1, i.p.) or NBQX (0.5 μg) microinjected into the nucleus accumbens (NAS) shell subregion. Intra-NAS shell administration of 7-OH-DPAT (5.0 μg) or NBQX (0.5 μg), alone or combined, failed to induce place conditioning, and this lack of effect was not due to state dependency. Administration of MK-801 or 7-OH-DPAT (5.0 mg kg−1) during the conditioning phase acutely increased horizontal activity, but neither compound, alone or combined, induced conditioned locomotor effects.

Conclusions

Acquisition of place conditioning induced by systemic administration of 7-OH-DPAT is blocked by systemic NMDA receptor antagonism by MK-801 or by the AMPA/kainate receptor antagonist NBQX microinjected into the NAS shell subregion.

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Acknowledgements

This work is funded by the Canadian Institutes of Health Research. R.L.H. Clements was the recipient of postgraduate scholarship from the Natural Sciences and Engineering Research Council of Canada (NSERC).

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Authors and Affiliations

  1. Department of Sociology, University of Alberta, Edmonton, Alberta, Canada

    Anna-Maria Biondo

  2. W.G. Dewhurst Laboratory, Department of Psychiatry, 1E7.44 Mackenzie Health Sciences Centre, University of Alberta, Edmonton, Alberta, T6G 2R7, Canada

    Robert L. H. Clements, David J. Hayes & Andrew J. Greenshaw

  3. Centre for Neuroscience, University of Alberta, Edmonton, Alberta, Canada

    Robert L. H. Clements, David J. Hayes & Andrew J. Greenshaw

  4. Department of Psychology, University of Alberta, Edmonton, Alberta, Canada

    Brendan Eshpeter

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  1. Anna-Maria Biondo
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  2. Robert L. H. Clements
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  5. Andrew J. Greenshaw
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Correspondence to Andrew J. Greenshaw.

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Anna-Maria Biondo and Robert L.H. Clements contributed equally to this work.

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Biondo, AM., Clements, R.L.H., Hayes, D.J. et al. NMDA or AMPA/kainate receptor blockade prevents acquisition of conditioned place preference induced by D2/3 dopamine receptor stimulation in rats. Psychopharmacology 179, 189–197 (2005). https://doi.org/10.1007/s00213-005-2201-y

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