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Granulosa Cells-Related MicroRNAs in Ovarian Diseases: Mechanism, Facts and Perspectives

  • Reproductive Biology: Review
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Abstract

MicroRNAs (miRNAs) are a class of short single-stranded, noncoding RNAs that affect the translation of mRNAs by imperfectly binding to homologous 3’UTRs. Research on miRNAs in ovarian diseases is constantly expanding because miRNAs are powerful regulators of gene expression and cellular processes and are promising biomarkers. miRNA mimics, miRNA inhibitors and molecules targeting miRNAs (antimiRs) have shown promise as novel therapeutic agents in preclinical development. Granulosa cells (GCs) are supporting cells for developing oocytes in the ovary. GCs regulate female reproductive health by producing sex hormones and LH receptors. Increasing research has reported the relevance of miRNAs in GC pathophysiology. With in-depth studies of disease mechanisms, there are an increasing number of studies on the biomolecular pathways of miRNAs in gynecology and endocrinology. In the present review, we summarize the different functions of GC-related microRNAs in various ovarian disorders, such as polycystic ovary syndrome, premature ovarian insufficiency, premature ovarian failure and ovarian granulosa cell tumors.

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Funding

This work was supported by the Natural Science Foundation of China (82305011).

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  1. Shengmin Xiao and Juan Du contributed equally to this work..

Authors and Affiliations

  1. School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 611137, People’s Republic of China

    Shengmin Xiao, Juan Du, Xiaohong Luo & Linjiang Song

  2. Department of Oncology, Hejiang Hospital of Traditional Chinese Medicine, Luzhou, 611137, People’s Republic of China

    Guanghui Yuan

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  1. Shengmin Xiao
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  2. Juan Du
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SX and LS designed the research and were responsible for the project conception. SX drafted the manuscript, together with LS and XL. SX revised the manuscript together with JD and GY. All of the authors read and approved the final version of the manuscript.

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Correspondence to Xiaohong Luo or Linjiang Song.

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Xiao, S., Du, J., Yuan, G. et al. Granulosa Cells-Related MicroRNAs in Ovarian Diseases: Mechanism, Facts and Perspectives. Reprod. Sci. (2024). https://doi.org/10.1007/s43032-024-01523-w

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