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Inflammation Markers in Type 2 Diabetes and the Metabolic Syndrome in the Pediatric Population

  • Pediatric Type 2 and Monogenic Diabetes (PS Zeitler and O Pinhas-Hamiel, Section Editors)
  • Published:
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Abstract

Purpose of Review

Chronic inflammation, adipokines, and hepatokines have been identified as basis of insulin resistance and β cell failure in animal models. We present our current knowledge concerning the potential relationship between these cytokines, inflammation, metabolic syndrome (MetS), and type 2 diabetes mellitus (T2DM) in the pediatric population.

Recent Findings

Pro-inflammatory cytokines related to insulin resistance and MetS in children are tumor necrosis factor-alpha (TNF-α), interleukin (IL)-6, IL-1β, interferon gamma, pigment epithelium-derived factor, chemerin, vaspin, and fetuin A. Anti-inflammatory cytokines associated with insulin resistance and MetS in children are leptin, adiponectin, omentin, fibroblast growth factor (FGF)-21, osteocalcin, and irisin. These anti-inflammatory cytokines are decreased (adiponectin, omentin, and osteocalcin) or increased (leptin, FGF-21, and irisin) in obesity suggesting a resistance state. TNF-α, fetuin A, and FGF-21 are altered in obese children with T2DM suggesting an involvement in β cell failure.

Summary

These cytokines, adipokines, and hepatokines may be able to predict development of MetS and T2DM and have a potential therapeutic target ameliorating insulin resistance.

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  1. Department of Pediatric Endocrinology, Diabetes and Nutrition Medicine, Vestische Hospital for Children and Adolescents Datteln, University of Witten/Herdecke, Dr. F. Steiner Str. 5, D-45711, Datteln, Germany

    Thomas Reinehr

  2. Center for Integrative Brain Research, Seattle Children’s Research Institute, 1900 Ninth Avenue, Seattle, WA, 98101, USA

    Christian Ludwig Roth

  3. Division of Endocrinology, Department of Pediatrics, University of Washington, Seattle, WA, 98105, USA

    Christian Ludwig Roth

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Reinehr, T., Roth, C.L. Inflammation Markers in Type 2 Diabetes and the Metabolic Syndrome in the Pediatric Population. Curr Diab Rep 18, 131 (2018). https://doi.org/10.1007/s11892-018-1110-5

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