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Serum Vaspin Concentrations in Relation to Insulin Sensitivity Following RYGB-Induced Weight Loss

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Abstract

Background

Recently, vaspin was identified as a novel adipokine with insulin-sensitizing effects that might be implicated in endogenous glucose regulation. Our objective was to evaluate the impact of acute weight loss and metabolic changes on serum vaspin concentrations in morbidly obese subjects following laparoscopic Roux-en-Y gastric bypass (RYGB) surgery.

Methods

Longitudinal, clinical intervention study in 33 morbidly obese subjects before and 12 months after RYGB was conducted. Fasting serum concentrations of vaspin were measured by a commercially available ELISA and correlated with BMI, parameters of insulin sensitivity, and other biochemical measurements. Fasting insulin sensitivity was estimated using the homeostasis model assessment (HOMA) of insulin resistance.

Results

RYGB-induced weight loss resulted in a reduction of circulating vaspin, leptin, insulin, and C-peptide levels as well as of BMI, HbA1c, and HOMA (p < 0.0001, respectively). Changes in serum vaspin concentrations correlated positively with those in HOMA, insulin, C-peptide, HbA1c, and leptin (p < 0.05, respectively) levels. The association between percent change of vaspin and HOMA remained significant even after the adjustment for RYGB-induced changes in BMI.

Conclusions

Following RYGB surgery, changes in serum vaspin concentrations correlate significantly with the reduction of circulating leptin, insulin, and C-peptide levels and with the amelioration of insulin sensitivity. However, further studies have to elucidate whether vaspin is only a biomarker for body-weight-related changes of insulin sensitivity or whether it is implicated in the regulation of human glucose homeostasis.

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Abbreviations

ALT:

Alanine-aminotransferase

AST:

Aspartate transaminase

BMI:

Body mass index

CRP:

C-Reactive protein

gGT:

Gamma glutamyl-transpeptidase

HDL-C:

High-density lipoprotein cholesterol

HOMA:

Homeostasis model assessment of insulin resistance

LDL-C:

Low-density lipoprotein cholesterol

Non-HDL-C:

Non-high-density lipoprotein cholesterol

OLETF:

Otsuka Long-Evans Tokushima Fatty

RYGB:

Laparascopic Roux-en-Y gastric bypass

S-creatinine:

Serum creatinine

TG:

Triglycerides

TC:

Total cholesterol

Vaspin:

Visceral adipose-tissue derived serpin

WAT:

White adipose tissue

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All authors have nothing to disclose.

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Authors and Affiliations

  1. Department of Internal Medicine III, Division of Endocrinology and Metabolism, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria

    Ammon Handisurya, Michaela Riedl, Greisa Vila, Christina Maier, Martin Clodi, Bernhard Ludvik, Anton Luger & Alexandra Kautzky-Willer

  2. Department of Internal Medicine III, Division of Nephrology, Medical University of Vienna, Vienna, Austria

    Thomas Prikoszovich

  3. Department of Surgery, Medical University of Vienna, Vienna, Austria

    Gerhard Prager

Authors
  1. Ammon Handisurya
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  2. Michaela Riedl
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  3. Greisa Vila
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  4. Christina Maier
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  5. Martin Clodi
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  6. Thomas Prikoszovich
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  7. Bernhard Ludvik
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  8. Gerhard Prager
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  9. Anton Luger
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  10. Alexandra Kautzky-Willer
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Corresponding author

Correspondence to Alexandra Kautzky-Willer.

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Handisurya, A., Riedl, M., Vila, G. et al. Serum Vaspin Concentrations in Relation to Insulin Sensitivity Following RYGB-Induced Weight Loss. OBES SURG 20, 198–203 (2010). https://doi.org/10.1007/s11695-009-9882-y

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  • DOI: https://doi.org/10.1007/s11695-009-9882-y

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