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Serum levels of fetuin A are increased in women with gestational diabetes mellitus

  • Gynecologic Endocrinology and Reproductive Medicine
  • Published:
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Abstract

Purpose

Fetuin A is associated with insulin resistance and type 2 diabetes mellitus (DM). We aimed to investigate circulating fetuin A concentrations in gestational diabetes mellitus (GDM).

Methods

Serum fetuin A levels were studied in 26 pregnant women with GDM and 24 healthy pregnant women between 24th and 28th gestational weeks. Fetuin A levels were also evaluated in 18 of women with GDM at postpartum.

Results

Fetuin A concentrations were significantly increased in women with GDM compared to healthy pregnant women (35.0 ± 3.2 vs. 32.0 ± 4.4 ng/ml; p = 0.01). Also, fetuin A levels in women with GDM significantly decreased at postpartum period (35.0 ± 3.2 vs. 31.7 ± 3.9 ng/ml; p = 0.001). In whole pregnant women, there were positive correlations between fetuin A and HbA1c (r = 0.418, p = 0.002), total cholesterol (r = 0.332, p = 0.018) and triglycerides (r = 0.306, p = 0.031). Multivariate regression analysis demonstrated that HbA1c was the important predictor of circulating fetuin A level (beta = 0.375, p = 0.01).

Conclusion

In conclusion, our results indicate that serum fetuin A concentrations are increased in women with GDM and decreased after delivery. Therefore, fetuin A might have a role in the development of insulin resistance and the metabolic changes in GDM.

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Acknowledgments

We gratefully thank Elif Ayvali for helping in laboratory analysis.

Conflict of interest

There is no conflict of interest to disclose.

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Authors and Affiliations

  1. Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara, Turkey

    Ozlem Turhan Iyidir, Ceyla Konca Degertekin, Banu Aktas Yilmaz, Alev E. Altinova, Fusun B. Toruner, Goksun Ayvaz & Mujde Akturk

  2. Department of Obstetrics and Gynecology, Gazi University Faculty of Medicine, Ankara, Turkey

    Nuray Bozkurt

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  1. Ozlem Turhan Iyidir
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  2. Ceyla Konca Degertekin
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Correspondence to Ozlem Turhan Iyidir.

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Iyidir, O.T., Degertekin, C.K., Yilmaz, B.A. et al. Serum levels of fetuin A are increased in women with gestational diabetes mellitus. Arch Gynecol Obstet 291, 933–937 (2015). https://doi.org/10.1007/s00404-014-3490-3

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  • DOI: https://doi.org/10.1007/s00404-014-3490-3

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