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Circulating pro-inflammatory cytokines and adiponectin in young men with type 2 diabetes

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Abstract

This study was designed to investigate plasma circulating pro-inflammatory cytokines, adiponectin and high-sensitive C-reactive protein (hsCRP) in young men with type 2 diabetes. New-onset young men with type 2 diabetes (young diabetes, YDM; age between 10 and 25) were recruited and divided into a non-obese group (NOYDM, body mass index, BMI ≦ 25 kg/m2, N = 23) and an obese group (OBYDM, BMI ≧ 25 kg/m2, N = 24). Twenty-four non-obese non-diabetic young men served as controls. Hemoglobin A1c, fasting glycemic index, lipids, adiponectin, hsCRP, tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were determined. Insulin sensitivity and β-cell function were calculated using the homeostasis model assessment method (HOMA-IR and HOMA-β, respectively). Compared to controls, significantly greater HOMA-IR (7.9 ± 1.9 and 10.4 ± 2.5 vs. 1.5 ± 0.3, P < 0.001) and fasting insulin (103.3 ± 21.1 and 209.9 ± 24.4 vs. 48.5 ± 6.7 pmol/l, P < 0.01 and P < 0.001, respectively) were observed in NOYDM and OBYDM. There were significantly lower plasma adiponectin and higher hsCRP and TNF-α levels in OBYDM, whereas higher TNF-α and IL-6 were shown in NOYDM. Spearman rank correlation analysis demonstrated significant correlations between BMI and adiponectin (R = −0.44, P < 0.005), CRP (R = 0.28, P < 0.05), TNF-α (R = 0.42, P < 0.005) and IL-6 (R = 0.33, P < 0.01) in all YDM. Among measured cytokines, only adiponectin was significantly correlated with HOMA-IR, this correlation was abolished when adjusted for age and BMI (R = −0.24, P = 0.12). YDM not only exhibits insulin resistance, but also has inflammatory and atherogenic properties. BMI might be a major determinant of those markers.

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Acknowledgments

We sincerely thank the study staff for their technical assistance, particularly Miss Wang for the laboratory measurements, and all of the patients who participated in this study. This work is supported by grants (TSGH-C94-075, TSGH-C95-S04 and TSGH-C99-166) from the Tri-Service General Hospital.

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Authors and Affiliations

  1. Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, 325, Section 2, Cheng-Kung Road, Neihu 114, Taipei, Taiwan, ROC

    Sheng-Chiang Su, Chang-Hsun Hsieh, Fone-Ching Hsiao & Yi-Jen Hung

  2. Division of Endocrinology and Metabolism, Department of Internal Medicine, Cardinal Tien Hospital, Xindian, Taiwan, ROC

    Dee Pei

  3. Division of Endocrinology and Metabolism, Department of Internal Medicine, Taipei Medical University-Shuang Ho Hospital, Taipei, Taiwan, ROC

    Chung-Ze Wu

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  1. Sheng-Chiang Su
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Correspondence to Yi-Jen Hung.

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Su, SC., Pei, D., Hsieh, CH. et al. Circulating pro-inflammatory cytokines and adiponectin in young men with type 2 diabetes. Acta Diabetol 48, 113–119 (2011). https://doi.org/10.1007/s00592-009-0171-y

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  • DOI: https://doi.org/10.1007/s00592-009-0171-y

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