Abstract
Background
Fluid challenge test is a widely used method for the detection of fluid responsiveness in acute circulatory failure. However, detection of the patient's response to the fluid challenge requires monitoring of cardiac output which is not feasible in many settings. We investigated whether the changes in the pulse oximetry-derived peripheral perfusion index (PPI), as a non-invasive surrogate of cardiac output, can detect fluid responsiveness using the fluid challenge test or not.
Methods
We prospectively enrolled 58 patients with septic shock on norepinephrine infusion. Fluid challenge test, using 200 mL crystalloid solution, was performed in all study subjects. All patients received an additional 300 mL crystalloid infusion to confirm fluid responsiveness. Velocity time integral (VTI) (using transthoracic echocardiography), and PPI were measured at the baseline, after 200 mL fluid challenge, and after completion of 500 mL crystalloids. Fluid responsiveness was defined by 10% increase in the VTI after completion of the 500 mL. The predictive ability of ∆PPI [Calculated as (PPI after 200 mL − baseline PPI)/baseline PPI] to detect fluid responders was obtained using the receiver operating characteristic curve.
Results
Forty-two patients (74%) were fluid responders; in whom, the mean arterial pressure, the central venous pressure, the VTI, and the PPI increased after fluid administration compared to the baseline values. ∆PPI showed moderate ability to detect fluid responders [area under receiver operating characteristic curve (95% confidence interval) 0.82 (0.70–0.91), sensitivity 76%, specificity 80%, positive predictive value 92%, negative predictive value 54%, cutoff value ≥ 5%]. There was a significant correlation between ∆PPI and ∆VTI induced by the fluid challenge.
Conclusion
∆PPI showed moderate ability to detect fluid responsiveness in patients with septic shock on norepinephrine infusion. Increased PPI after 200 mL crystalloid challenge can detect fluid responsiveness with a positive predictive value of 92%; however, failure of the PPI to increase does not exclude fluid responsiveness.
Clinical trial identifier
NCT03805321. Date of registration: 15 January 2019. Clinical trial registration URL: https://clinicaltrials.gov/ct2/show/NCT03805321?term=ahmed+hasanin&rank=9.
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Abbreviations
- APACHE:
-
Acute physiology and chronic health evaluation
- AUROC:
-
Area under receiver operating characteristic
- CI:
-
Confidence interval
- CO2 gap:
-
Central venous-arterial CO2 gap
- PPI:
-
Peripheral perfusion index
- ScVO2 :
-
Central venous oxygen saturation
- SPSS:
-
Statistical package for social science
- VTI:
-
Velocity time integral
References
Acheampong A, Vincent J-L. A positive fluid balance is an independent prognostic factor in patients with sepsis. Crit Care. 2015;19:251.
Hasanin A. Fluid responsiveness in acute circulatory failure. J Intensive Care. 2015;3:50.
Muller L, Toumi M, Bousquet P-J, Riu-Poulenc B, Louart G, Candela D, Zoric L, Suehs C, De La Coussaye JE, Molinari N, Lefrant JY, AzuRéa Group. An increase in aortic blood flow after an infusion of 100 ml colloid over 1 minute can predict fluid responsiveness the mini-fluid challenge study. Anesthesiology. 2011;115:541–7.
Mahjoub Y, Lejeune V, Muller L, Perbet S, Zieleskiewicz L, Bart F, Veber B, Paugam-Burtz C, Jaber S, Ayham A, Zogheib E, Lasocki S, Vieillard-Baron A, Quintard H, Joannes-Boyau O, Plantefève G, Montravers P, Duperret S, Lakhdari M, Ammenouche N, Lorne E, Slama M, Dupont H. Evaluation of pulse pressure variation validity criteria in critically ill patients: a prospective observational multicentre point-prevalence study. Br J Anaesth. 2014;112:681–5.
Xu J, Peng X, Pan C, Cai S, Zhang X, Xue M, Yang Y, Qiu H. Fluid responsiveness predicted by transcutaneous partial pressure of oxygen in patients with circulatory failure: a prospective study. Ann Intensive Care. 2017;7:56.
Jacquet-Lagrèze M, Bouhamri N, Portran P, Schweizer R, Baudin F, Lilot M, Fornier W, Fellahi JL. Capillary refill time variation induced by passive leg raising predicts capillary refill time response to volume expansion. Crit Care. 2019;23:281.
Butler E, Nguyen J, Mahendran S, Aneman A. Fluid responsiveness after cardiac surgery (FRACAS): a prospective observational study using peripheral near-infrared spectroscopy. J Cardiothorac Vasc Anesth. 2018;32:197–204.
Hasanin A, Mukhtar A, Nassar H. Perfusion indices revisited. J Intensive Care. 2017;5:24.
Beurton A, Teboul JL, Gavelli F, Gonzalez FA, Girotto V, Galarza L, Anguel N, Richard C, Monnet X. The effects of passive leg raising may be detected by the plethysmographic oxygen saturation signal in critically ill patients. Crit Care. 2019;23:19.
De Courson H, Michard F, Chavignier C, Verchère E, Nouette-Gaulain K, Biais M. Do changes in perfusion index reflect changes in stroke volume during preload-modifying manoeuvres? J Clin Monit Comput. 2020;34:1193–8.
Lima AP, Beelen P, Bakker J. Use of a peripheral perfusion index derived from the pulse oximetry signal as a noninvasive indicator of perfusion. Crit Care Med. 2002;30:1210–3.
Hasanin A, Mohamed SAR, El-adawy A. Evaluation of perfusion index as a tool for pain assessment in critically ill patients. J Clin Monit Comput. 2017;31:961–5.
Corsini I, Cecchi A, Coviello C, Dani C. Perfusion index and left ventricular output correlation in healthy term infants. Eur J Pediatr. 2017;176:1013–8.
Lian H, Wang X, Zhang Q, Zhang H, Liu D. Changes in perfusion can detect changes in the cardiac index in patients with septic shock. J Int Med Res. 2020;48:300060520931675.
Beurton A, Gavelli F, Teboul J-L, De Vita N, Monnet X. Changes in the plethysmographic perfusion index during an end-expiratory occlusion detect a positive passive leg raising test. Crit Care Med. 2020;49:e–151–e–160.
Lakhal K, Ehrmann S, Perrotin D, Wolff M, Boulain T. Fluid challenge: tracking changes in cardiac output with blood pressure monitoring (invasive or non-invasive). Intensive Care Med. 2013;39:1953–62.
Toscani L, Aya HD, Antonakaki D, Bastoni D, Watson X, Arulkumaran N, Rhodes A, Cecconi M. What is the impact of the fluid challenge technique on diagnosis of fluid responsiveness? A systematic review and meta-analysis. Crit Care. 2017;21:207.
Shi R, Monnet X, Teboul JL. Parameters of fluid responsiveness. Curr Opin Crit Care. 2020;26:319–26.
Kattan E, Hernández G, Ospina-Tascón G, Valenzuela ED, Bakker J, Castro R. A lactate-targeted resuscitation strategy may be associated with higher mortality in patients with septic shock and normal capillary refill time: a post hoc analysis of the ANDROMEDA-SHOCK study. Ann Intensive Care. 2020;10:1–9.
Castro R, Kattan E, Ferri G, Pairumani R, Valenzuela ED, Alegría L, Oviedo V, Pavez N, Soto D, Vera M, Santis C, Astudillo B, Cid MA, Bravo S, Ospina-Tascón G, Bakker J, Hernández G. Effects of capillary refill time-vs. lactate-targeted fluid resuscitation on regional, microcirculatory and hypoxia-related perfusion parameters in septic shock: a randomized controlled trial. Ann Intensive Care. 2020;10:150.
Jaffee W, Hodgins S, McGee WT. Tissue edema, fluid balance, and patient outcomes in severe sepsis: an organ systems review. J Intensive Care Med. 2018;33:502–9.
Lammi MR, Aiello B, Burg GT, Rehman T, Douglas IS, Wheeler AP, deBoisblanc BP, National Institutes of Health, National Heart, Lung, and Blood Institute ARDS Network Investigators. Response to fluid boluses in the fluid and catheter treatment trial. Chest. 2015;148:919–26.
Klijn E, van Velzen MHN, Lima AP, Bakker J, van Bommel J, Groeneveld ABJ. Tissue perfusion and oxygenation to monitor fluid responsiveness in critically ill, septic patients after initial resuscitation: a prospective observational study. J Clin Monit Comput. 2015;29:707–12.
Xu B, Yang X, Wang C, Jiang W, Weng L, Hu X, Peng J, Du B. Changes of central venous oxygen saturation define fluid responsiveness in patients with septic shock: a prospective observational study. J Crit Care. 2016;38:13–9.
Hasanin A, Mostafa M. Evaluation of fluid responsiveness during COVID-19 pandemic: what are the remaining choices? J Anesth. 2020;34:758–64.
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Hasanin, A., Karam, N., Mukhtar, A.M. et al. The ability of pulse oximetry-derived peripheral perfusion index to detect fluid responsiveness in patients with septic shock. J Anesth 35, 254–261 (2021). https://doi.org/10.1007/s00540-021-02908-w
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DOI: https://doi.org/10.1007/s00540-021-02908-w