Abstract
Cancer is a potentially fatal and complex genetic disease characterized by the dysregulation of genome stability and cell proliferation, cell survival and immune surveillance. As cancer is a leading cause of death and its late-stage diagnosis poses a major challenge today, there is an urgent need for actionable and druggable tumor-specific target genes. Large-scale transcriptome sequencing and analysis of cancer tissues and cell lines have uncovered a plethora of non-coding RNAs whose expression is closely associated with tumorigenesis. Among them, microRNAs and long non-coding RNAs are the two prominent non-coding post-transcriptional regulatory molecules, although their biogenesis, length, and mode-of-action mechanisms differ at the molecular level. Since subcellular localization and spatiotemporal expression patterns of microRNA and lncRNAs show fluctuation during different phases of cancer, they have been identified as a promising therapeutic target for diagnosing, monitoring and treating cancer. In this chapter, we will focus on the expression patterns of microRNA and lncRNAs in the most prevalent cancers in both females and males. We also discuss the potential clinical application of these non-coding RNAs in cancer treatment by summarizing potential targetablity and molecular interactions with mRNAs.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Abbastabar M, Sarfi M, Golestani A, Khalili E (2018) lncRNA involvement in hepatocellular carcinoma metastasis and prognosis. EXCLI J 17:900–913
Adam-Artigues A, Garrido-Cano I, Carbonell-Asins JA, Lameirinhas A, Simon S, Ortega-Morillo B, Martinez MT, Hernando C, Constancio V, Burgues O, Bermejo B, Henrique R, Lluch A, Jeronimo C, Eroles P, Cejalvo JM (2021a) Identification of a two-microRNA signature in plasma as a novel biomarker for very early diagnosis of breast cancer. Cancer 13:2848
Adam-Artigues A, Garrido-Cano I, Simon S, Ortega B, Moragon S, Lameirinhas A, Constancio V, Salta S, Burgues O, Bermejo B, Henrique R, Lluch A, Jeronimo C, Eroles P, Cejalvo JM (2021b) Circulating miR-30b-5p levels in plasma as a novel potential biomarker for early detection of breast cancer. ESMO Open 6:100039
Anastasiadou E, Jacob LS, Slack FJ (2018) Non-coding RNA networks in cancer. Nat Rev Cancer 18:5–18
Arab A, Karimipoor M, Irani S, Kiani A, Zeinali S, Tafsiri E, Sheikhy K (2017) Potential circulating miRNA signature for early detection of NSCLC. Cancer Genet 216–217:150–158
Arun G, Spector DL (2019) MALAT1 long non-coding RNA and breast cancer. RNA Biol 16:860–863
Asakura K, Kadota T, Matsuzaki J, Yoshida Y, Yamamoto Y, Nakagawa K, Takizawa S, Aoki Y, Nakamura E, Miura J, Sakamoto H, Kato K, Watanabe SI, Ochiya T (2020) A miRNA-based diagnostic model predicts resectable lung cancer in humans with high accuracy. Commun Biol 3:134
Bai P, Li W, Wan Z (2020) miR-489-3p inhibits prostate cancer progression by targeting DLX1. Cancer Manag Res 12:12581–12581
Barcelo M, Castells M, Bassas L, Vigues F, Larriba S (2019) Semen miRNAs contained in exosomes as non-invasive biomarkers for prostate cancer diagnosis. Sci Rep 9:13772
Baumgartner U, Berger F, Gheinani AH, Burgener SS, Monastyrskaya K, Vassella E (2018) miR-19b enhances proliferation and apoptosis resistance via the EGFR signaling pathway by targeting PP2A and BIM in non-small cell lung cancer. Mol Cancer 17:44
Bian EB, Ma CC, He XJ, Wang C, Zong G, Wang HL, Zhao B (2016) Epigenetic modification of miR-141 regulates SKA2 by an endogenous ‘sponge’ HOTAIR in glioma. Oncotarget 7:30610–30625
Bitaraf A, Babashah S, Garshasbi M (2020) Aberrant expression of a five-microRNA signature in breast carcinoma as a promising biomarker for diagnosis. J Clin Lab Anal 34:e23063
Bonci D, Coppola V, Musumeci M, Addario A, D’urso L, Collura D, Peschle C, de Maria R, Muto G (2009) The Mir-15a/Mir-16-1 cluster controls prostate cancer progression control by targeting of multiple oncogenic activities. J Urol 181:188–188
Brummer A, Hausser J (2014) MicroRNA binding sites in the coding region of mRNAs: extending the repertoire of post-transcriptional gene regulation. Bioessays 36:617–626
Cai H, Yuan Y, Hao YF, Guo TK, Wei X, Zhang YM (2013) Plasma microRNAs serve as novel potential biomarkers for early detection of gastric cancer. Med Oncol 30:452
Cai H, Liu X, Zheng J, Xue Y, Ma J, Li Z, Xi Z, Li Z, Bao M, Liu Y (2017) Long non-coding RNA taurine upregulated 1 enhances tumor-induced angiogenesis through inhibiting microRNA-299 in human glioblastoma. Oncogene 36:318–331
Calin GA, Croce CM (2006) MicroRNA signatures in human cancers. Nat Rev Cancer 6:857–866
Calin GA, Sevignani C, Dumitru CD, Hyslop T, Noch E, Yendamuri S, Shimizu M, Rattan S, Bullrich F, Negrini M, Croce CM (2004) Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci U S A 101:2999–3004
Cannistraci A, Hascoet P, Ali A, Mundra P, Clarke NW, Pavet V, Marais R (2022) MiR-378a inhibits glucose metabolism by suppressing GLUT1 in prostate cancer. Oncogene 41:1445–1455
Cao XN, Lai SY, Hu FY, Li GD, Wang GH, Luo XL, Fu XN, Hu JB (2017) miR-19a contributes to gefitinib resistance and epithelial mesenchymal transition in non-small cell lung cancer cells by targeting c-Met. Sci Rep 7:2939
Cao W, Cheng W, Wu W (2018) MicroRNAs reprogram tumor immune response. Methods Mol Biol 1699:67–74
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest ARR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato X, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, Di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SPT, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Babu MM, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S et al (2005) The transcriptional landscape of the mammalian genome. Science 309:1559–1563
Chen W, Bocker W, Brosius J, Tiedge H (1997) Expression of neural BC200 RNA in human tumours. J Pathol 183:345–351
Chen ZH, Zhang GL, Li HR, Luo JD, Li ZX, Chen GM, Yang J (2012) A panel of five circulating microRNAs as potential biomarkers for prostate cancer. Prostate 72:1443–1452
Chen W, Wang H, Chen H, Liu S, Lu H, Kong D, Huang X, Kong Q, Lu Z (2014a) Clinical significance and detection of microRNA-21 in serum of patients with diffuse large B-cell lymphoma in Chinese population. Eur J Haematol 92:407–412
Chen L, Lu MH, Zhang D, Hao NB, Fan YH, Wu YY, Wang SM, Xie R, Fang DC, Zhang H, Hu CJ, Yang SM (2014b) miR-1207-5p and miR-1266 suppress gastric cancer growth and invasion by targeting telomerase reverse transcriptase. Cell Death Dis 5:e1034
Chen L, Xiao H, Wang ZH, Huang Y, Liu ZP, Ren H, Song H (2014c) miR-29a suppresses growth and invasion of gastric cancer cells in vitro by targeting VEGF-A. BMB Rep 47:39–44
Chen CL, Tseng YW, Wu JC, Chen GY, Lin KC, Hwang SM, Hu YC (2015) Suppression of hepatocellular carcinoma by baculovirus-mediated expression of long non-coding RNA PTENP1 and MicroRNA regulation. Biomaterials 44:71–81
Chen X, Wu L, Li DZ, Xu YM, Zhang LP, Niu K, Kong R, Gu JY, Xu ZH, Chen ZT, Sun JG (2018a) Radiosensitizing effects of miR-18a-5p on lung cancer stem-like cells via downregulating both ATM and HIF-1 alpha. Cancer Med 7:3834–3847
Chen LJ, Wang XQ, Zhu YH, Zhu J, Lai QZ (2018b) miR-200b-3p inhibits proliferation and induces apoptosis in colorectal cancer by targeting Wnt1. Mol Med Rep 18:2571–2580
Chen L, Gao HB, Liang JT, Qiao JJ, Duan J, Shi HJ, Zhen TT, Li H, Zhang FF, Zhu ZW, Han AJ (2018c) miR-203a-3p promotes colorectal cancer proliferation and migration by targeting PDE4D. Am J Cancer Res 8:2387–2401
Chen TM, Xiao Q, Wang XJ, Wang ZQ, Hu JW, Zhang Z, Gong ZN, Chen SL (2019) miR-16 regulates proliferation and invasion of lung cancer cells via the ERK/MAPK signaling pathway by targeted inhibition of MAPK kinase 1 (MEK1). J Int Med Res 47:5194–5204
Chen Z, Gao Y, Gao S, Song D, Feng Y (2020a) MiR-135b-5p promotes viability, proliferation, migration and invasion of gastric cancer cells by targeting Kruppel-like factor 4 (KLF4). Arch Med Sci 16:167–176
Chen M, Zhang R, Lu L, Du J, Chen C, Ding K, Wei X, Zhang G, Huang Y, Hou J (2020b) LncRNA PVT1 accelerates malignant phenotypes of bladder cancer cells by modulating miR-194-5p/BCLAF1 axis as a ceRNA. Aging (Albany NY) 12:22291–22312
Chen L, Qian X, Wang Z, Zhou X (2021a) The HOTAIR lncRNA: a remarkable oncogenic promoter in human cancer metastasis. Oncol Lett 21:302
Chen ZH, Li Y, Tan BB, Li F, Zhao Q, Fan LQ, Zhang ZD, Zhao XF, Liu Y, Wang D (2021b) Long non-coding RNA ASNR targeting miR-519e-5p promotes gastric cancer development by regulating FGFR2. Front Cell Dev Biol 9:679176
Chiang CH, Chu PY, Hou MF, Hung WC (2016) MiR-182 promotes proliferation and invasion and elevates the HIF-1 alpha-VEGF-A axis in breast cancer cells by targeting FBXW7. American. J Cancer Res 6:1785
Chiou GY, Cherng JY, Hsu HS, Wang ML, Tsai CM, Lu KH, Chien Y, Hung SC, Chen YW, Wong CI, Tseng LM, Huang PI, Yu CC, Hsu WH, Chiou SH (2012) Cationic polyurethanes-short branch PEI-mediated delivery of Mir145 inhibited epithelial-mesenchymal transdifferentiation and cancer stem-like properties and in lung adenocarcinoma. J Control Release 159:240–250
Choi S, Lee S, Han YH, Choi J, Kim I, Lee J, An HJ (2022) miR-31-3p functions as a tumor suppressor by directly targeting GABBR2 in prostate cancer. Front Oncol 12:945057
Chung S, Nakagawa H, Uemura M, Piao L, Ashikawa K, Hosono N, Takata R, Akamatsu S, Kawaguchi T, Morizono T, Tsunoda T, Daigo Y, Matsuda K, Kamatani N, Nakamura Y, Kubo M (2011) Association of a novel long non-coding RNA in 8q24 with prostate cancer susceptibility. Cancer Sci 102:245–252
Cieslik M, Chinnaiyan AM (2018) Cancer transcriptome profiling at the juncture of clinical translation. Nat Rev Genet 19:93–109
Cornett AL, Lutz CS (2014) Regulation of COX-2 expression by miR-146a in lung cancer cells. RNA 20:1419–1430
Cortez MA, Bueso-Ramos C, Ferdin J, Lopez-Berestein G, Sood AK, Calin GA (2011) MicroRNAs in body fluids--the mix of hormones and biomarkers. Nat Rev Clin Oncol 8:467–477
Cory S, Adams JM (2019) A joint odyssey into cancer genetics. Annu Rev Cancer Biol 3(3):1–19
Cui M, Wang H, Yao X, Zhang D, Xie Y, Cui R, Zhang X (2019a) Circulating microRNAs in cancer: potential and challenge. Front Genet 10:626
Cui L, Nai M, Zhang K, Li L, Li R (2019b) lncRNA WT1-AS inhibits the aggressiveness of cervical cancer cell via regulating p53 expression via sponging miR-330-5p. Cancer Manag Res 11:651–667
Dai FQ, Li CR, Fan XQ, Tan L, Wang RT, Jin H (2019) miR-150-5p Inhibits non-small-cell lung cancer metastasis and recurrence by targeting HMGA2 and beta-catenin signaling. Mol Ther Nucleic Acids 16:675–685
Dai T, Zhao X, Li Y, Yu L, Li Y, Zhou X, Gong Q (2020) miR-423 promotes breast cancer invasion by activating NF-kappaB signaling. Onco Targets Ther 13:5467–5478
Dastmalchi N, Hosseinpourfeizi MA, Khojasteh SMB, Baradaran B, Safaralizadeh R (2020) Tumor suppressive activity of miR-424-5p in breast cancer cells through targeting PD-L1 and modulating PTEN/PI3K/AKT/mTOR signaling pathway. Life Sci 259:118239
Deng M, Tang HL, Lu XH, Liu MY, Lu XM, Gu YX, Liu JF, He ZM (2013) miR-26a suppresses tumor growth and metastasis by targeting FGF9 in gastric cancer. PLoS One 8:e72662
Deng YH, Deng ZH, Hao H, Wu XL, Gao H, Tang SH, Tang H (2018) MicroRNA-23a promotes colorectal cancer cell survival by targeting PDK4. Exp Cell Res 373:171–179
Ding L, Xu YJ, Zhang W, Deng YJ, Si MS, Du Y, Yao HM, Liu XY, Ke YH, Si JM, Zhou TH (2010) MiR-375 frequently downregulated in gastric cancer inhibits cell proliferation by targeting JAK2. Cell Res 20:784–793
Du L, Zhao Z, Ma X, Hsiao TH, Chen Y, Young E, Suraokar M, Wistuba I, Minna JD, Pertsemlidis A (2014) miR-93-directed downregulation of DAB2 defines a novel oncogenic pathway in lung cancer. Oncogene 33:4307–4315
Duan J, Zhang H, Qu Y, Deng T, Huang D, Liu R, Zhang L, Bai M, Zhou L, Ying G, Ba Y (2016) Onco-miR-130 promotes cell proliferation and migration by targeting TGFbetaR2 in gastric cancer. Oncotarget 7:44522–44533
Duan X, Qiao S, Li D, Li S, Zheng Z, Wang Q, Zhu X (2021) Circulating miRNAs in serum as biomarkers for early diagnosis of non-small cell lung cancer. Front Genet 12:673926
Esteller M (2011) Non-coding RNAs in human disease. Nat Rev Genet 12:861–874
Feng F, Liu H, Chen AP, Xia QH, Zhao Y, Jin XB, Huang JJ (2019) miR-148-3p and miR-152-3p synergistically regulate prostate cancer progression via repressing KLF4. J Cell Biochem 120:17228–17239
Filippova EA, Fridman MV, Burdennyy AM, Loginov VI, Pronina IV, Lukina SS, Dmitriev AA, Braga EA (2021) Long noncoding RNA GAS5 in breast cancer: epigenetic mechanisms and biological functions. Int J Mol Sci 22:6810
Flores-Perez A, Marchat LA, Rodriguez-Cuevas S, Bautista-Pina V, Hidalgo-Miranda A, Ocampo EA, Martinez MS, Palma-Flores C, Fonseca-Sanchez MA, Astudillo-De La Vega H, Ruiz-Garcia E, Gonzalez-Barrios JA, Perez-Plasencia C, Streber ML, Lopez-Camarillo C (2016) Dual targeting of ANGPT1 and TGFBR2 genes by miR-204 controls angiogenesis in breast cancer. Sci Rep 6:34504
Friedman RC, Farh KK, Burge CB, Bartel DP (2009) Most mammalian mRNAs are conserved targets of microRNAs. Genome Res 19:92–105
Fu Q, Sun ZY, Yang F, Mao TC, Gao YY, Wang H (2019) SOX30, a target gene of miR-653-5p, represses the proliferation and invasion of prostate cancer cells through inhibition of Wnt/beta-catenin signaling. Cell Mol Biol Lett 24:71
Gao Y, Yu H, Liu Y, Liu X, Zheng J, Ma J, Gong W, Chen J, Zhao L, Tian Y, Xue Y (2018) Long non-coding RNA HOXA-AS2 regulates malignant glioma behaviors and vasculogenic mimicry formation via the MiR-373/EGFR axis. Cell Physiol Biochem 45:131–147
Gehring WJ, Hiromi Y (1986) Homeotic genes and the homeobox. Annu Rev Genet 20:147–173
Ghafouri-Fard S, Taheri M (2019a) Maternally expressed gene 3 (MEG3): a tumor suppressor long non coding RNA. Biomed Pharmacother 118:109129
Ghafouri-Fard S, Taheri M (2019b) UCA1 long non-coding RNA: an update on its roles in malignant behavior of cancers. Biomed Pharmacother 120:109459
Ghafouri-Fard S, Dashti S, Hussen BM, Farsi M, Taheri M (2021) BCYRN1: an oncogenic lncRNA in diverse cancers. Pathol Res Pract 220:153385
Gil N, Ulitsky I (2020) Regulation of gene expression by cis-acting long non-coding RNAs. Nat Rev Genet 21:102–117
Goyal B, Yadav SRM, Awasthee N, Gupta S, Kunnumakkara AB, Gupta SC (2021) Diagnostic, prognostic, and therapeutic significance of long non-coding RNA MALAT1 in cancer. Biochim Biophys Acta Rev Cancer 1875:188502
Grunnet M, Sorensen JB (2012) Carcinoembryonic antigen (CEA) as tumor marker in lung cancer. Lung Cancer 76:138–143
Gu Y, Pais G, Becker V, Korbel C, Ampofo E, Ebert E, Hohneck J, Ludwig N, Meese E, Bohle RM, Zhao YJ, Menger MD, Laschke MW (2021a) Suppression of endothelial miR-22 mediates non-small cell lung cancer cell-induced angiogenesis. Mol Ther Nucleic Acids 26:849–864
Gu ZH, You ZX, Yang YC, Ding R, Wang ML, Pu JM, Chen J (2021b) Inhibition of MicroRNA miR-101-3p on prostate cancer progression by regulating Cullin 4B (CUL4B) and PI3K/AKT/mTOR signaling pathways. Bioengineered 12:4719–4735
Guffanti A, Iacono M, Pelucchi P, Kim N, Solda G, Croft LJ, Taft RJ, Rizzi E, Askarian-Amiri M, Bonnal RJ, Callari M, Mignone F, Pesole G, Bertalot G, Bernardi LR, Albertini A, Lee C, Mattick JS, Zucchi I, de Bellis G (2009) A transcriptional sketch of a primary human breast cancer by 454 deep sequencing. BMC Genomics 10:163
Gunelli R, Fragala E, Fiori M (2021) PCA3 in prostate cancer. Methods Mol Biol 2292:105–113
Guo TM, Zheng CZ, Wang ZG, Zheng XF (2019) miR-584-5p regulates migration and invasion in non-small cell lung cancer cell lines through regulation of MMP-14. Mol Med Rep 19:1747–1752
Guo YJ, Pan WW, Liu SB, Shen ZF, Xu Y, Hu LL (2020) ERK/MAPK signalling pathway and tumorigenesis. Exp Ther Med 19:1997–2007
Hamamoto J, Soejima K, Yoda S, Naoki K, Nakayama S, Satomi R, Terai H, Ikemura S, Sato T, Yasuda H, Hayashi Y, Sakamoto M, Takebayashi T, Betsuyaku T (2013) Identification of microRNAs differentially expressed between lung squamous cell carcinoma and lung adenocarcinoma. Mol Med Rep 8:456–462
Hamfjord J, Stangeland AM, Hughes T, Skrede ML, Tveit KM, Ikdahl T, Kure EH (2012) Differential expression of miRNAs in colorectal cancer: comparison of paired tumor tissue and adjacent normal mucosa using high-throughput sequencing. PLoS One 7:e34150
Han LP, Fu T, Lin Y, Miao JL, Jiang QF (2016) MicroRNA-138 negatively regulates non-small cell lung cancer cells through the interaction with cyclin D3. Tumor Biol 37:291–298
Han Q, Cheng P, Yang HJ, Liang HP, Lin FC (2019) Altered expression of microRNA-365 is related to the occurrence and development of non-small-cell lung cancer by inhibiting TRIM25 expression. J Cell Physiol 234:22321–22330
Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144:646–674
Hawkes N (2019) Cancer survival data emphasise importance of early diagnosis. BMJ 364:l408
He XH, Zou KJ (2020) MiRNA-96-5p contributed to the proliferation of gastric cancer cells by targeting FOXO3. J Biochem 167:101–108
He Q, Fang Y, Lu F, Pan J, Wang L, Gong W, Fei F, Cui J, Zhong J, Hu R, Liang M, Fang L, Wang H, Yu M, Zhang ZF (2019a) Analysis of differential expression profile of miRNA in peripheral blood of patients with lung cancer. J Clin Lab Anal 33:e23003
He C, Lu XW, Yang F, Qin L, Guo ZF, Sun Y, Wu JW (2019b) LncRNA UCA1 acts as a sponge of miR-204 to up-regulate CXCR4 expression and promote prostate cancer progression. Biosci Rep 39:BSR20181465
He QL, Ye AH, Ye WBA, Liao XM, Qin GQ, Xu YQ, Yin YT, Luo HQ, Yi MH, Xian LY, Zhang SA, Qin XY, Zhu W, Li YL (2021) Cancer-secreted exosomal miR-21-5p induces angiogenesis and vascular permeability by targeting KRIT1. Cell Death Dis 12:576
Hill M, Tran N (2021) miRNA interplay: mechanisms and consequences in cancer. Dis Model Mech 14:dmm047662
Hirschfeld M, Rucker G, Weiss D, Berner K, Ritter A, Jager M, Erbes T (2020) Urinary exosomal microRNAs as potential non-invasive biomarkers in breast cancer detection. Mol Diagn Ther 24:215–232
Ho CS, Noor SM, Nagoor NH (2018) MiR-378 and MiR-1827 regulate tumor invasion, migration and angiogenesis in human lung adenocarcinoma by targeting RBX1 and CRKL, respectively. J Cancer 9:331–345
Hong H, Yu HZ, Yuan JF, Guo CY, Cao HY, Li WB, Xiao CH (2016) MicroRNA-200b impacts breast cancer cell migration and invasion by regulating ezrin-radixin-moesin. Med Sci Monit 22:1946–1952
Hosono Y, Niknafs YS, Prensner JR, Iyer MK, Dhanasekaran SM, Mehra R, Pitchiaya S, Tien J, Escara-Wilke J, Poliakov A, Chu SC, Saleh S, Sankar K, Su FY, Guo SL, Qiao YY, Freier SM, Bui HH, Cao XH, Malik R, Johnson TM, Beer DG, Feng FY, Zhou WB, Chinnaiyan AM (2017) Oncogenic role of THOR, a conserved cancer/testis long non-coding RNA. Cell 171:1559
Hou P, Zhao Y, Li Z, Yao R, Ma M, Gao Y, Zhao L, Zhang Y, Huang B, Lu J (2014) LincRNA-ROR induces epithelial-to-mesenchymal transition and contributes to breast cancer tumorigenesis and metastasis. Cell Death Dis 5:e1287
Hou XW, Sun X, Yu Y, Zhao HM, Yang ZJ, Wang X, Cao XC (2017) miR-361-5p suppresses lung cancer cell lines progression by targeting FOXM1. Neoplasma 64:526–534
Hou ZH, Xu XW, Fu XY, Zhou LD, Liu SP, Tan DM (2020) Long non-coding RNA MALAT1 promotes angiogenesis and immunosuppressive properties of HCC cells by sponging miR-140. Am J Physiol Cell Physiol 318:C649–C663
Hu XY, Miao JY, Zhang M, Wang XF, Wang ZZ, Han J, Tong DD, Huang C (2018) miRNA-103a-3p promotes human gastric cancer cell proliferation by targeting and suppressing ATF7 in vitro. Mol Cells 41:390–400
Hu Y, French SW, Chau T, Liu HX, Sheng L, Wei F, Stondell J, Garcia JC, Du Y, Bowlus CL, Wan YY (2019) RARbeta acts as both an upstream regulator and downstream effector of miR-22, which epigenetically regulates NUR77 to induce apoptosis of colon cancer cells. FASEB J 33:2314–2326
Huang Z, Huang D, Ni S, Peng Z, Sheng W, Du X (2010) Plasma microRNAs are promising novel biomarkers for early detection of colorectal cancer. Int J Cancer 127:118–126
Huang Z, Zhu D, Wu L, He M, Zhou X, Zhang L, Zhang H, Wang W, Zhu J, Cheng W, Chen Y, Fan Y, Qi L, Yin Y, Zhu W, Shu Y, Liu P (2017) Six serum-based miRNAs as potential diagnostic biomarkers for gastric cancer. Cancer Epidemiol Biomarkers Prev 26:188–196
Huang ZM, Ge HF, Yang CC, Cai Y, Chen Z, Tian WZ, Tao JL (2019) MicroRNA-26a-5p inhibits breast cancer cell growth by suppressing RNF6 expression. Kaohsiung J Med Sci 35:467–473
Huang WT, Zhang H, Jin Z, Li K, Hu C, Li ML, Situ J (2020) MiR-219-5p inhibits prostate cancer cell growth and metastasis by targeting HMGA2. Eur Rev Med Pharmacol Sci 24:4710–4718
Huarte M, Guttman M, Feldser D, Garber M, Koziol MJ, Kenzelmann-Broz D, Khalil AM, Zuk O, Amit I, Rabani M, Attardi LD, Regev A, Lander ES, Jacks T, Rinn JL (2010) A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response. Cell 142:409–419
Itani MM, Nassar FJ, Tfayli AH, Talhouk RS, Chamandi GK, Itani ARS, Makoukji J, Boustany RN, Hou L, Zgheib NK, Nasr RR (2021) A signature of four circulating microRNAs as potential biomarkers for diagnosing early-stage breast cancer. Int J Mol Sci 22:6121
Iwasaki H, Shimura T, Yamada T, Okuda Y, Natsume M, Kitagawa M, Horike SI, Kataoka H (2019) A novel urinary microRNA biomarker panel for detecting gastric cancer. J Gastroenterol 54:1061–1069
Iwasaki H, Shimura T, Kitagawa M, Yamada T, Nishigaki R, Fukusada S, Okuda Y, Katano T, Horike SI, Kataoka H (2022) A novel urinary miRNA biomarker for early detection of colorectal cancer. Cancer 14:461
Iyer MK, Niknafs YS, Malik R, Singhal U, Sahu A, Hosono Y, Barrette TR, Prensner JR, Evans JR, Zhao S, Poliakov A, Cao XH, Dhanasekaran SM, Wu YM, Robinson DR, Beer DG, Feng FY, Iyer HK, Chinnaiyan AM (2015) The landscape of long noncoding RNAs in the human transcriptome. Nat Genet 47:199
Jana S, Sengupta S, Biswas S, Chatterjee A, Roy H, Bhattacharyya A (2017) miR-216b suppresses breast cancer growth and metastasis by targeting SDCBP. Biochem Biophys Res Commun 482:126–133
Jang JY, Kim YS, Kang KN, Kim KH, Park YJ, Kim CW (2021) Multiple microRNAs as biomarkers for early breast cancer diagnosis. Mol Clin Oncol 14:31
Jiang Z, Yin J, Fu W, Mo Y, Pan Y, Dai L, Huang H, Li S, Zhao J (2014) MiRNA 17 family regulates cisplatin-resistant and metastasis by targeting TGFbetaR2 in NSCLC. PloS One 9:e94639
Jin TF, Kim HS, Choi SK, Hwang EH, Woo J, Ryu HS, Kim K, Moon A, Moon WK (2017) microRNA-200c/141 upregulates SerpinB2 to promote breast cancer cell metastasis and reduce patient survival. Oncotarget 8:32769–32782
Jusoh AR, Mohan SV, Lu Ping T, Tengku Din T, Haron J, Romli RC, Jaafar H, Nafi SN, Tuan Salwani TI, Yahya MM (2021) Plasma circulating mirnas profiling for identification of potential breast cancer early detection biomarkers. Asian Pac J Cancer Prev 22:1375–1381
Kang SM, Lee HJ, Cho JY (2013) MicroRNA-365 regulates NKX2-1, a key mediator of lung cancer. Cancer Lett 335:487–494
Kavakiotis I, Alexiou A, Tastsoglou S, Vlachos IS, Hatzigeorgiou AG (2022) DIANA-miTED: a microRNA tissue expression database. Nucleic Acids Res 50:D1055–D1061
Kim TW, Lee YS, Yun NH, Shin CH, Hong HK, Kim HH, Cho YB (2020) MicroRNA-17-5p regulates EMT by targeting vimentin in colorectal cancer. Br J Cancer 123:1123–1130
Kino T, Hurt DE, Ichijo T, Nader N, Chrousos GP (2010) Noncoding RNA Gas5 is a growth arrest- and starvation-associated repressor of the glucocorticoid receptor. Sci Signal 3:ra8
Kohlan AK, Saidijam M, Amini R, Samadi P, Najafi R (2019) Induction of let-7e gene expression attenuates oncogenic phenotype in HCT-116 colorectal cancer cells through targeting of DCLK1 regulation. Life Sci 228:221–227
Kong P, Chen L, Yu M, Tao J, Liu J, Wang Y, Pan H, Zhou W, Wang S (2018) miR-3178 inhibits cell proliferation and metastasis by targeting Notch1 in triple-negative breast cancer. Cell Death Dis 9:1059
Lanz RB, Chua SS, Barron N, Soder BM, Demayo F, O’Malley BW (2003) Steroid receptor RNA activator stimulates proliferation as well as apoptosis in vivo. Mol Cell Biol 23:7163–7176
Lee TJ, Yuan X, Kerr K, Yoo JY, Kim DH, Kaur B, Eltzschig HK (2020) Strategies to modulate microRNA functions for the treatment of cancer or organ injury. Pharmacol Rev 72:639–667
Lee SB, Park YS, Sung JS, Lee JW, Kim B, Kim YH (2021) Tumor suppressor miR-584-5p inhibits migration and invasion in smoking related non-small cell lung cancer cells by targeting YKT6. Cancer 13:1159
Li LS, Xie XH, Luo JM, Liu M, Xi SY, Guo JL, Kong YN, Wu MQ, Gao J, Xie ZM, Tang J, Wang X, Wei WD, Yang MT, Hung MC, Xie XM (2012) Targeted expression of miR-34a using the T-VISA system suppresses breast cancer cell growth and invasion. Mol Ther 20:2326–2334
Li W, Zhai L, Zhao C, Lv S (2015a) MiR-153 inhibits epithelial-mesenchymal transition by targeting metadherin in human breast cancer. Breast Cancer Res Treat 150:501–509
Li T, Xie J, Shen C, Cheng D, Shi Y, Wu Z, Deng X, Chen H, Shen B, Peng C, Li H, Zhan Q, Zhu Z (2015b) Amplification of long noncoding RNA ZFAS1 promotes metastasis in hepatocellular carcinoma. Cancer Res 75:3181–3191
Li YL, Wang J, Zhang CY, Shen YQ, Wang HM, Ding L, Gu YC, Lou JT, Zhao XT, Ma ZL, Jin YX (2016a) MiR-146a-5p inhibits cell proliferation and cell cycle progression in NSCLC cell lines by targeting CCND1 and CCND2. Oncotarget 7:59287–59298
Li H, Ouyang RY, Wang Z, Zhou WH, Chen HY, Jiang YW, Zhang YB, Li H, Liao MT, Wang WW, Ye M, Ding ZG, Feng XP, Liu J, Zhang B (2016b) MiR-150 promotes cellular metastasis in non-small cell lung cancer by targeting FOXO4. Sci Rep 6:39001
Li Y, Cai B, Shen L, Dong Y, Lu Q, Sun S, Liu S, Ma S, Ma PX, Chen J (2017) MiRNA-29b suppresses tumor growth through simultaneously inhibiting angiogenesis and tumorigenesis by targeting Akt3. Cancer Lett 397:111–119
Li HM, Li JF, Yang TS, Lin SW, Li H (2018a) MicroRNA-433 represses proliferation and invasion of colon cancer cells by targeting homeobox A1. Oncol Res 26:315–322
Li J, Zou K, Yu L, Zhao W, Lu Y, Mao J, Wang B, Wang L, Fan S, Song B, Li L (2018b) MicroRNA-140 inhibits the epithelial-mesenchymal transition and metastasis in colorectal cancer. Mol Ther Nucleic Acids 10:426–437
Li SM, Wu HL, Yu X, Tang K, Wang SG, Ye ZQ, Hu J (2018c) The putative tumour suppressor miR-1-3p modulates prostate cancer cell aggressiveness by repressing E2F5 and PFTK1. J Exp Clin Cancer Res 37:219
Li ZX, Zhu QN, Zhang HB, Hu Y, Wang G, Zhu YS (2018d) MALAT1: a potential biomarker in cancer. Cancer Manag Res 10:6757–6768
Li J, Li Y, Meng F, Fu L, Kong C (2018e) Knockdown of long non-coding RNA linc00511 suppresses proliferation and promotes apoptosis of bladder cancer cells via suppressing Wnt/beta-catenin signaling pathway. Biosci Rep 38:BSR20171701
Li M, Zou X, Xia T, Wang T, Liu P, Zhou X, Wang S, Zhu W (2019a) A five-miRNA panel in plasma was identified for breast cancer diagnosis. Cancer Med 8:7006–7017
Li Z, Tang X, Duan S (2019b) Interference from LncRNA SPRY4-IT1 restrains the proliferation, migration, and invasion of melanoma cells through inactivating MAPK pathway by up-regulating miR-22-3p. Int J Clin Exp Pathol 12:477–487
Li L, Wang A, Cai M, Tong M, Chen F, Huang L (2020a) Identification of stool miR-135b-5p as a non-invasive diaognostic biomarker in later tumor stage of colorectal cancer. Life Sci 260:118417
Li Y, Liang M, Zhang YH, Yuan B, Gao WC, Shi ZZ, Bai J (2020b) miR-93, miR-373, and miR-17-5p negatively regulate the expression of TBP2 in lung cancer. Front Oncol 10:526
Li Y, Wang YW, Chen X, Ma RR, Guo XY, Liu HT, Jiang SJ, Wei JM, Gao P (2020c) MicroRNA-4472 promotes tumor proliferation and aggressiveness in breast cancer by targeting RGMA and inducing EMT. Clin Breast Cancer 20:e113–e126
Li YK, Zhong W, Zhu M, Li MB, Yang ZW (2020d) miR-185 inhibits prostate cancer angiogenesis induced by the nodal/ALK4 pathway. BMC Urol 20:49
Li XM, Yu M, Yang CY (2020e) YY1-mediated overexpression of long noncoding RNA MCM3AP-AS1 accelerates angiogenesis and progression in lung cancer by targeting miR-340-5p/KPNA4 axis. J Cell Biochem 121:2258–2267
Li Z, Li LX, Diao YJ, Wang J, Ye Y, Hao XK (2021) Identification of urinary exosomal miRNAs for the non-invasive diagnosis of prostate cancer. Cancer Manag Res 13:25–35
Li RD, Qu H, Wang SB, Chater JM, Wang XS, Cui YR, Yu L, Zhou R, Jia Q, Traband R, Wang MY, Xie WB, Yuan DB, Zhu JG, Zhong WD, Jia ZY (2022) CancerMIRNome: an interactive analysis and visualization database for miRNome profiles of human cancer. Nucleic Acids Res 50:D1139–D1146
Liang C, Zhang X, Wang HM, Liu XM, Zhang XJ, Zheng B, Qian GR, Ma ZL (2017) MicroRNA-18a-5p functions as an oncogene by directly targeting IRF2 in lung cancer. Cell Death Dis 8:e2764
Liang YK, Lin HY, Dou XW, Chen M, Wei XL, Zhang YQ, Wu Y, Chen CF, Bai JW, Xiao YS, Qi YZ, Kruyt FAE, Zhang GJ (2018) MiR-221/222 promote epithelial-mesenchymal transition by targeting Notch3 in breast cancer cell lines. NPJ Breast Cancer 4:20
Lin CP, He L (2017) Noncoding RNAs in cancer development. Annu Rev Cancer Biol 1(1):163–184
Lin JT, Tsai KW (2021) Circulating miRNAs act as diagnostic biomarkers for bladder cancer in urine. Int J Mol Sci 22:4278
Lin CW, Chang YL, Chang YC, Lin JC, Chen CC, Pan SH, Wu CT, Chen HY, Yang SC, Hong TM, Yang PC (2013) MicroRNA-135b promotes lung cancer metastasis by regulating multiple targets in the Hippo pathway and LZTS1. Nat Commun 4:1877
Ling B, Wang GX, Long G, Qiu JH, Hu ZL (2012) Tumor suppressor miR-22 suppresses lung cancer cell progression through post-transcriptional regulation of ErbB3. J Cancer Res Clin Oncol 138:1355–1361
Liu H, Zhu L, Liu B, Yang L, Meng X, Zhang W, Ma Y, Xiao H (2012) Genome-wide microRNA profiles identify miR-378 as a serum biomarker for early detection of gastric cancer. Cancer Lett 316:196–203
Liu HX, Huang J, Peng J, Wu XX, Zhang Y, Zhu WL, Guo LL (2015a) Upregulation of the inwardly rectifying potassium channel Kir2.1 (KCNJ2) modulates multidrug resistance of small-cell lung cancer under the regulation of miR-7 and the Ras/MAPK pathway. Mol Cancer 14:59
Liu X, Ge X, Zhang Z, Zhang X, Chang J, Wu Z, Tang W, Gan L, Sun M, Li J (2015b) MicroRNA-940 promotes tumor cell invasion and metastasis by downregulating ZNF24 in gastric cancer. Oncotarget 6:25418–25428
Liu L, Meng T, Wang QS, Jin HZ, Sun ZQ, Jin B, Fang F, Wang HJ (2016) Association of Beclin-1 and microRNA-30a expression with the severity and treatment response of colorectal cancer. Genet Mol Res 15. https://doi.org/10.4238/gmr.15027704
Liu FY, Cai YJ, Rong XX, Chen JZ, Zheng DY, Chen L, Zhang JY, Luo RC, Zhao P, Ruan J (2017) MiR-661 promotes tumor invasion and metastasis by directly inhibiting RB1 in non small cell lung cancer. Mol Cancer 16:122
Liu X, Pan B, Sun L, Chen X, Zeng K, Hu X, Xu T, Xu M, Wang S (2018a) Circulating exosomal miR-27a and miR-130a act as novel diagnostic and prognostic biomarkers of colorectal cancer. Cancer Epidemiol Biomarkers Prev 27:746–754
Liu TC, Wu XP, Chen T, Luo ZW, Hu XH (2018b) Downregulation of DNMT3A by miR-708-5p inhibits lung cancer stem cell-like phenotypes through repressing Wnt/beta-catenin signaling. Clin Cancer Res 24:1748–1760
Liu X, Xu X, Pan B, He B, Chen X, Zeng K, Xu M, Pan Y, Sun H, Xu T, Hu X, Wang S (2019) Circulating miR-1290 and miR-320d as novel diagnostic biomarkers of human colorectal cancer. J Cancer 10:43–50
Lou W, Ding B, Zhong G, Du C, Fan W, Fu P (2019) Dysregulation of pseudogene/lncRNA-hsa-miR-363-3p-SPOCK2 pathway fuels stage progression of ovarian cancer. Aging (Albany NY) 11:11416–11439
Lou N, Liu G, Pan Y (2020) Long noncoding RNA ANRIL as a novel biomarker in human cancer. Future Oncol 16:2981–2995
Lu L, Luo F, Liu Y, Liu X, Shi L, Lu X, Liu Q (2015) Posttranscriptional silencing of the lncRNA MALAT1 by miR-217 inhibits the epithelial-mesenchymal transition via enhancer of zeste homolog 2 in the malignant transformation of HBE cells induced by cigarette smoke extract. Toxicol Appl Pharmacol 289:276–285
Lu MH, Tang B, Zeng S, Hu CJ, Xie R, Wu YY, Wang SM, He FT, Yang SM (2016) Long noncoding RNA BC032469, a novel competing endogenous RNA, upregulates hTERT expression by sponging miR-1207-5p and promotes proliferation in gastric cancer. Oncogene 35:3524–3534
Lu S, Kong H, Hou Y, Ge D, Huang W, Ou J, Yang D, Zhang L, Wu G, Song Y, Zhang X, Zhai C, Wang Q, Zhu H, Wu Y, Bai C (2018) Two plasma microRNA panels for diagnosis and subtype discrimination of lung cancer. Lung Cancer 123:44–51
Lu Q, Chen YC, Sun D, Wang SK, Ding K, Liu MY, Zhang Y, Miao YJ, Liu HC, Zhou FH (2019) MicroRNA-181a functions as an oncogene in gastric cancer by targeting caprin-1. Front Pharmacol 9:1565
Ma L, Reinhardt F, Pan E, Soutschek J, Bhat B, Marcusson EG, Teruya-Feldstein J, Bell GW, Weinberg RA (2010) Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model. Nat Biotechnol 28:341–U67
Ma C, Nong K, Zhu H, Wang W, Huang X, Yuan Z, Ai K (2014) H19 promotes pancreatic cancer metastasis by derepressing let-7′s suppression on its target HMGA2-mediated EMT. Tumour Biol 35:9163–9169
Ma MZ, Chu BF, Zhang Y, Weng MZ, Qin YY, Gong W, Quan ZW (2015) Long non-coding RNA CCAT1 promotes gallbladder cancer development via negative modulation of miRNA-218-5p. Cell Death Dis 6:e1583
Ma ZW, Luo YZ, Qiu MX (2017) miR-143 induces the apoptosis of prostate cancer LNCap cells by suppressing Bcl-2 expression. Med Sci Monit 23:359–365
Ma YL, Yan F, Wei WJ, Deng J, Li L, Liu L, Sun JH (2019) MicroRNA-598 inhibits the growth and maintenance of gastric cancer stem-like cells by down-regulating RRS1. Cell Cycle 18:2757–2769
Marrugo-Ramirez J, Mir M, Samitier J (2018) Blood-based cancer biomarkers in liquid biopsy: a promising non-invasive alternative to tissue biopsy. Int J Mol Sci 19:2877
Matin F, Jeet V, Moya L, Selth LA, Chambers S, Australian Prostate Cancer BioResource, Clements JA, Batra J (2018) A plasma biomarker panel of four microRNAs for the diagnosis of prostate cancer. Sci Rep 8:6653
Mei Y, Li K, Zhang ZC, Li MM, Yang H, Wang H, Huang XM, Li XY, Shi SH, Yang HJ (2021) miR-33b-3p acts as a tumor suppressor by targeting DOCK4 in prostate cancer. Front Oncol 11:740452
Mendez MG, Kojima S, Goldman RD (2010) Vimentin induces changes in cell shape, motility, and adhesion during the epithelial to mesenchymal transition. FASEB J 24:1838–1851
Meng W, McElroy JP, Volinia S, Palatini J, Warner S, Ayers LW, Palanichamy K, Chakravarti A, Lautenschlaeger T (2013) Comparison of microRNA deep sequencing of matched formalin-fixed paraffin-embedded and fresh frozen cancer tissues. PLoS One 8:e64393
Menon A, Abd-Aziz N, Khalid K, Poh CL, Naidu R (2022) miRNA: a promising therapeutic target in cancer. Int J Mol Sci 23:11502
Mitchell PS, Parkin RK, Kroh EM, Fritz BR, Wyman SK, Pogosova-Agadjanyan EL, Peterson A, Noteboom J, O’Briant KC, Allen A, Lin DW, Urban N, Drescher CW, Knudsen BS, Stirewalt DL, Gentleman R, Vessella RL, Nelson PS, Martin DB, Tewari M (2008) Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci U S A 105:10513–10518
Ng EKO, Tsang WP, Ng SSM, Jin HC, Yu J, Li JJ, Rocken C, Ebert MPA, Kwok TT, Sung JJY (2009) MicroRNA-143 targets DNA methyltransferases 3A in colorectal cancer. Br J Cancer 101:699–706
Ni Y, Li C, Bo C, Zhang B, Liu Y, Bai X, Cui B, Han P (2020) LncRNA EGOT regulates the proliferation and apoptosis of colorectal cancer by miR-33b-5p/CROT axis. Biosci Rep BSR20193893
Niveditha D, Jasoria M, Narayan J, Majumder S, Mukherjee S, Chowdhury R, Chowdhury S (2020) Common and unique microRNAs in multiple carcinomas regulate similar network of pathways to mediate cancer progression. Sci Rep 10:2331
O’Brien J, Hayder H, Zayed Y, Peng C (2018) Overview of microRNA biogenesis, mechanisms of actions, and circulation. Front Endocrinol (Lausanne) 9:402
O’Brien SJ, Fiechter C, Burton J, Hallion J, Paas M, Patel A, Patel A, Rochet A, Scheurlen K, Gardner S, Eichenberger M, Sarojini H, Srivastava S, Rai S, Kalbfleisch T, Polk HC Jr, Galandiuk S (2021) Long non-coding RNA ZFAS1 is a major regulator of epithelial-mesenchymal transition through miR-200/ZEB1/E-cadherin, vimentin signaling in colon adenocarcinoma. Cell Death Dis 7:61
Orom UA, Nielsen FC, Lund AH (2008) MicroRNA-10a binds the 5′UTR of ribosomal protein mRNAs and enhances their translation. Mol Cell 30:460–471
Othman N, Nagoor NH (2019) Overexpression of miR-361-5p plays an oncogenic role in human lung adenocarcinoma through the regulation of SMAD2. Int J Oncol 54:306–314
Otmani K, Lewalle P (2021) Tumor suppressor miRNA in cancer cells and the tumor microenvironment: mechanism of deregulation and clinical implications. Front Oncol 11:708765
Pakravan K, Babashah S, Sadeghizadeh M, Mowla SJ, Mossahebi-Mohammadi M, Ataei F, Dana N, Javan M (2017) MicroRNA-100 shuttled by mesenchymal stem cell-derived exosomes suppresses in vitro angiogenesis through modulating the mTOR/HIF-1alpha/VEGF signaling axis in breast cancer cells. Cell Oncol (Dordr) 40:457–470
Pan Z, Miao L (2020) Serum microRNA-592 serves as a novel potential biomarker for early diagnosis of colorectal cancer. Oncol Lett 20:1119–1126
Pan J, Zhou C, Zhao X, He J, Tian H, Shen W, Han Y, Chen J, Fang S, Meng X, Jin X, Gong Z (2018) A two-miRNA signature (miR-33a-5p and miR-128-3p) in whole blood as potential biomarker for early diagnosis of lung cancer. Sci Rep 8:16699
Paraskevopoulou MD, Hatzigeorgiou AG (2016) Analyzing MiRNA-LncRNA interactions. Methods Mol Biol 1402:271–286
Park Y, Kim J (2019) Regulation of IL-6 signaling by miR-125a and let-7e in endothelial cells controls vasculogenic mimicry formation of breast cancer cells. BMB Rep 52:214–219
Park DH, Jeon HS, Lee SY, Choi YY, Lee HW, Yoon S, Lee JC, Yoon YS, Kim DS, Na MJ, Kwon SJ, Kim DS, Kang J, Park JY, Son JW (2015) MicroRNA-146a inhibits epithelial mesenchymal transition in non-small cell lung cancer by targeting insulin receptor substrate 2. Int J Oncol 47:1545–1553
Peng B, Li C, He L, Tian M, Li X (2020) miR-660-5p promotes breast cancer progression through down-regulating TET2 and activating PI3K/AKT/mTOR signaling. Braz J Med Biol Res 53:e9740
Porzycki P, Ciszkowicz E, Semik M, Tyrka M (2018) Combination of three miRNA (hsa-miR-141, hsa-miR-21, and hsa-miR-375) as potential diagnostic tool for prostate cancer recognition. Int Urol Nephrol 50:1619–1626
Qi JH, Ebrahem Q, Moore N, Murphy G, Claesson-Welsh L, Bond M, Baker A, Anand-Apte B (2003) A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2. Nat Med 9:407–415
Qiu X, Zhang J, Shi W, Liu S, Kang M, Chu H, Wu D, Tong N, Gong W, Tao G, Zhao Q, Qiang F, Zhu H, Wu Q, Wang M, Zhang Z (2016) Circulating microRNA-26a in plasma and its potential diagnostic value in gastric cancer. PLoS One 11:e0151345
Rajagopal T, Talluri S, Akshaya RL, Dunna NR (2020) HOTAIR LncRNA: a novel oncogenic propellant in human cancer. Clin Chim Acta 503:1–18
Ren Y, Zhang H, Jiang P (2018) MicroRNA-382 inhibits cell growth and migration in colorectal cancer by targeting SP1. Biol Res 51:51
Ren Z, Liu XC, Si YR, Yang DS (2020) Long non-coding RNA DDX11-AS1 facilitates gastric cancer progression by regulating miR-873-5p/SPC18 axis. Artif Cells Nanomed Biotechnol 48:572–583
Reyes-Gonzalez JM, Vivas-Mejia PE (2021) c-MYC and epithelial ovarian cancer. Front Oncol 11:601512
Rosenfeld N, Aharonov R, Meiri E, Rosenwald S, Spector Y, Zepeniuk M, Benjamin H, Shabes N, Tabak S, Levy A, Lebanony D, Goren Y, Silberschein E, Targan N, Ben-Ari A, Gilad S, Sion-Vardy N, Tobar A, Feinmesser M, Kharenko O, Nativ O, Nass D, Perelman M, Yosepovich A, Shalmon B, Polak-Charcon S, Fridman E, Avniel A, Bentwich I, Bentwich Z, Cohen D, Chajut A, Barshack I (2008) MicroRNAs accurately identify cancer tissue origin. Nat Biotechnol 26:462–469
Ryu SW, Lee SJ, Park MY, Jun JI, Jung YK, Kim E (2003) Fas-associated factor 1, FAF1, is a member of Fas death-inducing signaling complex. J Biol Chem 278:24003–24010
Saito T, Kurashige J, Nambara S, Komatsu H, Hirata H, Ueda M, Sakimura S, Uchi R, Takano Y, Shinden Y, Iguchi T, Eguchi H, Ehata S, Murakami K, Sugimachi K, Mimori K (2015) A long non-coding RNA activated by transforming growth factor-beta is an independent prognostic marker of gastric cancer. Ann Surg Oncol 22(suppl 3):S915–S922
Salinas-Vera YM, Marchat LA, Garcia-Vazquez R, Gonzalez De La Rosa CH, Castaneda-Saucedo E, Tito NN, Flores CP, Perez-Plasencia C, Cruz-Colin JL, Carlos-Reyes A, Lopez-Gonzalez JS, Alvarez-Sanchez ME, Lopez-Camarillo C (2018) Cooperative multi-targeting of signaling networks by angiomiR-204 inhibits vasculogenic mimicry in breast cancer cells. Cancer Lett 432:17–27
Samson J, Cronin S, Dean K (2018) BC200 (BCYRN1) - the shortest, long, non-coding RNA associated with cancer. Noncoding RNA Res 3:131–143
Santiago K, Chen Wongworawat Y, Khan S (2020) Differential microRNA-signatures in thyroid cancer subtypes. J Oncol 2020:2052396
Serva A, Knapp B, Tsai YT, Claas C, Lisauskas T, Matula P, Harder N, Kaderali L, Rohr K, Erfle H, Eils R, Braga V, Starkuviene V (2012) miR-17-5p regulates endocytic trafficking through targeting TBC1D2/Armus. PloS One 7:e52555
Shahabi A, Naghili B, Ansarin K, Montazeri M, Dadashpour M, Zarghami N (2021) Let-7d and miR-185 impede epithelial-mesenchymal transition by downregulating Rab25 in breast cancer. Asian Pac J Cancer Prev 22:305–313
Shen H, Zhu F, Liu JY, Xu TP, Pei D, Wang R, Qian YY, Li Q, Wang L, Shi ZM, Zheng JT, Chen QD, Jiang BH, Shu YQ (2014a) Alteration in Mir-21/PTEN expression modulates gefitinib resistance in non-small cell lung cancer. PloS One 9:e103305
Shen ZY, Zhang ZZ, Liu H, Zhao EH, Cao H (2014b) miR-375 inhibits the proliferation of gastric cancer cells by repressing ERBB2 expression. Exp Ther Med 7:1757–1761
Shermane Lim YW, Xiang X, Garg M, Le MT, Li-Ann Wong A, Wang L, Goh BC (2021) The double-edged sword of H19 lncRNA: insights into cancer therapy. Cancer Lett 500:253–262
Shi DB, Wang YW, Xing AY, Gao JW, Zhang H, Guo XY, Gao P (2015) C/EBPalpha-induced miR-100 expression suppresses tumor metastasis and growth by targeting ZBTB7A in gastric cancer. Cancer Lett 369:376–385
Shi Y, Wang Z, Zhu X, Chen L, Ma Y, Wang J, Yang X, Liu Z (2020) Exosomal miR-1246 in serum as a potential biomarker for early diagnosis of gastric cancer. Int J Clin Oncol 25:89–99
Shimomura A, Shiino S, Kawauchi J, Takizawa S, Sakamoto H, Matsuzaki J, Ono M, Takeshita F, Niida S, Shimizu C, Fujiwara Y, Kinoshita T, Tamura K, Ochiya T (2016) Novel combination of serum microRNA for detecting breast cancer in the early stage. Cancer Sci 107:326–334
Shin VY, Siu JM, Cheuk I, Ng EK, Kwong A (2015) Circulating cell-free miRNAs as biomarker for triple-negative breast cancer. Br J Cancer 112:1751–1759
Sohel MMH (2020) Circulating microRNAs as biomarkers in cancer diagnosis. Life Sci 248:117473
Sokilde R, Vincent M, Moller AK, Hansen A, Hoiby PE, Blondal T, Nielsen BS, Daugaard G, Moller S, Litman T (2014) Efficient identification of miRNAs for classification of tumor origin. J Mol Diagn 16:106–115
Srivastava A, Goldberger H, Dimtchev A, Ramalinga M, Chijioke J, Marian C, Oermann EK, Uhm S, Kim JS, Chen LN, Li X, Berry DL, Kallakury BV, Chauhan SC, Collins SP, Suy S, Kumar D (2013) MicroRNA profiling in prostate cancer--the diagnostic potential of urinary miR-205 and miR-214. PLoS One 8:e76994
Su C, Huang DP, Liu JW, Liu WY, Cao YO (2019) miR-27a-3p regulates proliferation and apoptosis of colon cancer cells by potentially targeting BTG1. Oncol Lett 18:2825–2834
Sun D, Fan XH (2019) LncRNA SNHG12 accelerates the progression of ovarian cancer via absorbing miRNA-129 to upregulate SOX4. Eur Rev Med Pharmacol Sci 23:2345–2352
Sun W, Wang XJ, Li JL, You CY, Lu P, Feng HJ, Kong Y, Zhang HY, Liu YQ, Jiao RH, Chen X, Ba Y (2018a) MicroRNA-181a promotes angiogenesis in colorectal cancer by targeting SRCIN1 to promote the SRC/VEGF signaling pathway. Cell Death Dis 9:438
Sun Q, Weng DH, Li KZ, Li S, Bai XY, Fang C, Luo DF, Wu P, Chen G, Wei JC (2018b) MicroRNA-139-5P inhibits human prostate cancer cell proliferation by targeting Notch1. Oncol Lett 16:793–800
Sun SN, Hang TY, Zhang BY, Zhu L, Wu Y, Lv XW, Huang Q, Yao HH (2019) miRNA-708 functions as a tumor suppressor in colorectal cancer by targeting ZEB1 through Akt/mTOR signaling pathway. Am J Transl Res 11:5338–5356
Sun B, Liu C, Li H, Zhang L, Luo G, Liang S, Lu M (2020) Research progress on the interactions between long non-coding RNAs and microRNAs in human cancer. Oncol Lett 19:595–605
Sun XB, Chen YW, Yao QS, Chen XH, He M, Chen CB, Yang Y, Gong XX, Huang L (2021) MicroRNA-144 suppresses prostate cancer growth and metastasis by targeting EZH2. Technol Cancer Res Treat 20:1533033821989817
Switlik WZ, Karbownik MS, Suwalski M, Kozak J, Szemraj J (2019) Serum miR-210-3p as a potential noninvasive biomarker of lung adenocarcinoma: a preliminary study. Genet Test Mol Biomarkers 23:353–358
Tang S, Cheng J, Yao Y, Lou C, Wang L, Huang X, Zhang Y (2020) Combination of four serum exosomal MiRNAs as novel diagnostic biomarkers for early-stage gastric cancer. Front Genet 11:237
Taniguchi T, Ogasawara K, Takaoka A, Tanaka N (2001) IRF family of transcription factors as regulators of host defense. Annu Rev Immunol 19:623–655
Turnbull C, Sud A, Houlston RS (2018) Cancer genetics, precision prevention and a call to action. Nat Genet 50:1212–1218
Tutar L, Ozgur A, Tutar Y (2018) Involvement of miRNAs and pseudogenes in cancer. Methods Mol Biol 1699:45–66
Uhlen M, Zhang C, Lee S, Sjostedt E, Fagerberg L, Bidkhori G, Benfeitas R, Arif M, Liu ZT, Edfors F, Sanli K, von Feilitzen K, Oksvold P, Lundberg E, Hober S, Nilsson P, Mattsson J, Schwenk JM, Brunnstrom H, Glimelius B, Sjoblom T, Edqvist PH, Djureinovic D, Micke P, Lindskog C, Mardinoglu A, Ponten F (2017) A pathology atlas of the human cancer transcriptome. Science 357:660
Vandewalle C, van Roy F, Berx G (2009) The role of the ZEB family of transcription factors in development and disease. Cell Mol Life Sci 66:773–787
Viticchie G, Lena AM, Latina A, Formosa A, Gregersen LH, Lund AH, Bernardini S, Mauriello A, Miano R, Spagnoli LG, Knight RA, Candi E, Melino G (2011) MiR-203 controls proliferation, migration and invasive potential of prostate cancer cell lines. Cell Cycle 10:1121–1131
Vo JN, Cieslik M, Zhang YJ, Shukla S, Xiao LB, Zhang YP, Wu YM, Dhanasekaran SM, Engelke CG, Cao XH, Robinson DR, Nesvizhskii AI, Chinnaiyan AM (2019) The landscape of circular RNA in cancer. Cell 176:869
Vychytilova-Faltejskova P, Radova L, Sachlova M, Kosarova Z, Slaba K, Fabian P, Grolich T, Prochazka V, Kala Z, Svoboda M, Kiss I, Vyzula R, Slaby O (2016) Serum-based microRNA signatures in early diagnosis and prognosis prediction of colon cancer. Carcinogenesis 37:941–950
Wang YX, Qin HY (2018) miR-338-3p targets RAB23 and suppresses tumorigenicity of prostate cancer cells. Am J Cancer Res 8:2564–2574
Wang XT, Arai S, Song XY, Reichart D, Du K, Pascual G, Tempst P, Rosenfeld MG, Glass CK, Kurokawa R (2008) Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription. Nature 454:126–130
Wang K, Zhang S, Weber J, Baxter D, Galas DJ (2010) Export of microRNAs and microRNA-protective protein by mammalian cells. Nucleic Acids Res 38:7248–7259
Wang S, Xiang J, Li Z, Lu S, Hu J, Gao X, Yu L, Wang L, Wang J, Wu Y, Chen Z, Zhu H (2015) A plasma microRNA panel for early detection of colorectal cancer. Int J Cancer 136:152–161
Wang SZ, Ma GX, Zhu HX, Lv CY, Chu HY, Tong N, Wu DM, Qiang FL, Gong WD, Zhao QH, Tao GQ, Zhou JW, Zhang ZD, Wang ML (2016) miR-107 regulates tumor progression by targeting NF1 in gastric cancer. Sci Rep 6:36531
Wang Y, Li YQ, Wu B, Shi C, Li C (2017) MicroRNA-661 promotes non-small cell lung cancer progression by directly targeting RUNX3. Mol Med Rep 16:2113–2120
Wang H, Peng R, Wang J, Qin Z, Xue L (2018a) Circulating microRNAs as potential cancer biomarkers: the advantage and disadvantage. Clin Epigenetics 10:59
Wang ZH, Yang B, Zhang M, Guo WW, Wu ZY, Wang Y, Jia L, Li S, Xie W, Yang D, Cancer Genome Atlas Research Network (2018b) lncRNA epigenetic landscape analysis identifies EPIC1 as an oncogenic lncRNA that interacts with MYC and promotes cell-cycle progression in cancer. Cancer Cell 33:706
Wang Y, Xu W, Wang Y, Xu X, Lv S, Dong X (2019a) miR-17-5p promotes migration and invasion in breast cancer cells by repressing netrin 4. Int J Clin Exp Pathol 12:1649–1657
Wang Y, Zhang S, Dang S, Fang X, Liu M (2019b) Overexpression of microRNA-216a inhibits autophagy by targeting regulated MAP1S in colorectal cancer. Onco Targets Ther 12:4621–4629
Wang Y, Li WJ, Chen XY, Li Y, Wen PH, Xu F (2019c) MIR210HG predicts poor prognosis and functions as an oncogenic lncRNA in hepatocellular carcinoma. Biomed Pharmacother 111:1297–1301
Wang XK, Lan ZX, He J, Lai QH, Yao X, Li QY, Liu YF, Lai HS, Gu CC, Yan Q, Fang YX, Zhang Y, Li AM, Liu SD (2019d) LncRNA SNHG6 promotes chemoresistance through ULK1-induced autophagy by sponging miR-26a-5p in colorectal cancer cells. Cancer Cell Int 19:234
Wang C, Huang Y, Zhang J, Fang Y (2020a) MiRNA-339-5p suppresses the malignant development of gastric cancer via targeting ALKBH1. Exp Mol Pathol 115:104449
Wang W, Hu WT, Wang Y, An Y, Song L, Shang PF, Yue ZJ (2020b) Long non-coding RNA UCA1 promotes malignant phenotypes of renal cancer cells by modulating the miR-182-5p/DLL4 axis as a ceRNA. Mol Cancer 19:18
Wang MY, Zhao MN, Guo QM, Lou JT, Wang L (2021a) Non-small cell lung cancer cell-derived exosomal miR-17-5p promotes osteoclast differentiation by targeting PTEN. Exp Cell Res 408:112834
Wang J, Zhu YM, Ni S, Liu SY (2021b) LncRNA GAS5 suppressed proliferation and promoted apoptosis in laryngeal squamous cell carcinoma by targeting MiR-26a-5p and modifying ULK2. Cancer Manage Res 13:871–887
Weber JA, Baxter DH, Zhang S, Huang DY, Huang KH, Lee MJ, Galas DJ, Wang K (2010) The microRNA spectrum in 12 body fluids. Clin Chem 56:1733–1741
Wei AW, Li LF (2017) Long non-coding RNA SOX21-AS1 sponges miR-145 to promote the tumorigenesis of colorectal cancer by targeting MYO6. Biomed Pharmacother 96:953–959
Wiemer EA (2007) The role of microRNAs in cancer: no small matter. Eur J Cancer 43:1529–1544
Wu JG, Wang JJ, Jiang X, Lan JP, He XJ, Wang HJ, Ma YY, Xia YJ, Ru GQ, Ma J, Zhao ZS, Zhou R (2015) MiR-125b promotes cell migration and invasion by targeting PPP1CA-Rb signal pathways in gastric cancer, resulting in a poor prognosis. Gastric Cancer 18:729–739
Wu ZH, Cai XH, Huang CG, Xu J, Liu A (2016) miR-497 suppresses angiogenesis in breast carcinoma by targeting HIF-1 alpha. Oncol Rep 35:1696–1702
Wu W, He K, Guo Q, Chen J, Zhang M, Huang K, Yang D, Wu L, Deng Y, Luo X, Yu H, Ding Q, Xiang G (2019a) SSRP1 promotes colorectal cancer progression and is negatively regulated by miR-28-5p. J Cell Mol Med 23:3118–3129
Wu M, Huang Y, Chen T, Wang W, Yang S, Ye Z, Xi X (2019b) LncRNA MEG3 inhibits the progression of prostate cancer by modulating miR-9-5p/QKI-5 axis. J Cell Mol Med 23:29–38
Xie F, Hosany S, Zhong S, Jiang Y, Zhang F, Lin L, Wang X, Gao S, Hu X (2017) MicroRNA-193a inhibits breast cancer proliferation and metastasis by downregulating WT1. PLoS One 12:e0185565
Xie Y, Zhao J, Liang YL, Chen M, Luo YH, Cui XB, Jiang B, Peng L, Wang XY (2019) MicroRNA-10b controls the metastasis and proliferation of colorectal cancer cells by regulating Kruppel-like factor 4. Artif Cells Nanomed Biotechnol 47:1722–1729
Xin H, Wang C, Liu Z (2019) miR-196a-5p promotes metastasis of colorectal cancer via targeting IkappaBalpha. BMC Cancer 19:30
Xu Y, Li J, Wang P, Zhang Z, Wang X (2019) LncRNA HULC promotes lung squamous cell carcinoma by regulating PTPRO via NF-kappaB. J Cell Biochem 120:19415–19421
Xu GC, Meng Y, Wang LH, Dong B, Peng FF, Liu ST, Li SK, Liu T (2021a) miRNA-214-5p inhibits prostate cancer cell proliferation by targeting SOX4. World J Surg Oncol 19:338
Xu H, He Y, Lin L, Li M, Zhou Z, Yang Y (2021b) MiR-1207-5p targets PYCR1 to inhibit the progression of prostate cancer. Biochem Biophys Res Commun 575:56–64
Xu J, Li X, Zhang PR, Luo J, Mou EX, Liu SW (2022) miR-143-5p suppresses breast cancer progression by targeting the HIF-1 alpha-related GLUT1 pathway. Oncol Lett 23:147
Xue M, Pang H, Li X, Li H, Pan J, Chen W (2016) Long non-coding RNA urothelial cancer-associated 1 promotes bladder cancer cell migration and invasion by way of the hsa-miR-145-ZEB1/2-FSCN1 pathway. Cancer Sci 107:18–27
Yang Z, Zhou L, Wu LM, Lai MC, Xie HY, Zhang F, Zheng SS (2011) Overexpression of long non-coding RNA HOTAIR predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation. Ann Surg Oncol 18:1243–1250
Yang J, Zhang Z, Chen C, Liu Y, Si Q, Chuang TH, Li N, Gomez-Cabrero A, Reisfeld RA, Xiang R, Luo Y (2014) MicroRNA-19a-3p inhibits breast cancer progression and metastasis by inducing macrophage polarization through downregulated expression of Fra-1 proto-oncogene. Oncogene 33:3014–3023
Yang H, Luo JW, Liu ZG, Zhou R, Luo H (2015) MicroRNA-138 regulates DNA damage response in small cell lung cancer cells by directly targeting H2AX. Cancer Invest 33:126–136
Yang X, Zhang Q, Zhang M, Su W, Wang Z, Li Y, Zhang J, Beer DG, Yang S, Chen G (2019) Serum microRNA signature is capable of early diagnosis for non-small cell lung cancer. Int J Biol Sci 15:1712–1722
Yang HB, Zhang XG, Zhu L, Yang Y, Yin XM (2021) YY1-induced lncRNA PART1 enhanced resistance of ovarian cancer cells to cisplatin by regulating miR-512-3p/CHRAC1 axis. DNA Cell Biol 40:821–832
Yao Q, Chen Y, Zhou X (2019) The roles of microRNAs in epigenetic regulation. Curr Opin Chem Biol 51:11–17
Yap KL, Li SD, Munoz-Cabello AM, Raguz S, Zeng L, Mujtaba S, Gil J, Walsh MJ, Zhou MM (2010) Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a. Mol Cell 38:662–674
Ye MF, Lin D, Li WJ, Xu HP, Zhang J (2020) MiR-26a-5p serves as an oncogenic microRNA in non-small cell lung cancer by targeting FAF1. Cancer Manage Res 12:7131–7142
Yerukala Sathipati S, Ho SY (2018) Identifying a miRNA signature for predicting the stage of breast cancer. Sci Rep 8:16138
Yi Z, Fu Y, Zhao S, Zhang X, Ma C (2010) Differential expression of miRNA patterns in renal cell carcinoma and nontumorous tissues. J Cancer Res Clin Oncol 136:855–862
Yong FL, Law CW, Wang CW (2013) Potentiality of a triple microRNA classifier: miR-193a-3p, miR-23a and miR-338-5p for early detection of colorectal cancer. BMC Cancer 13:280
Yu X, Zhang X, Bi T, Ding Y, Zhao J, Wang C, Jia T, Han D, Guo G, Wang B, Jiang J, Cui S (2013) MiRNA expression signature for potentially predicting the prognosis of ovarian serous carcinoma. Tumour Biol 34:3501–3508
Yu JJ, Lu YY, Cui D, Li EH, Zhu YP, Zhao YY, Zhao FJ, Xia SJ (2014) miR-200b suppresses cell proliferation, migration and enhances chemosensitivity in prostate cancer by regulating Bmi-1. Oncol Rep 31:910–918
Yu Y, Chen Q, Zhang X, Yang J, Lin K, Ji C, Xu A, Yang L, Miao L (2020a) Long noncoding RNA ANRIL promotes the malignant progression of cholangiocarcinoma by epigenetically repressing ERRFI1 expression. Cancer Sci 111:2297–2309
Yu L, Shao X, Huo L, Zhang T (2020b) Long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) promotes cell proliferation and migration by regulating miR-143-3p and MAGE Family Member A9 (MAGEA9) in oral squamous cell carcinoma. Med Sci Monit 26:e924187
Yuan C, Zhu X, Han Y, Song C, Liu C, Lu S, Zhang M, Yu F, Peng Z, Zhou C (2016) Elevated HOXA1 expression correlates with accelerated tumor cell proliferation and poor prognosis in gastric cancer partly via cyclin D1. J Exp Clin Cancer Res 35:15
Yuan C, Zhang Y, Tu W, Guo Y (2019) Integrated miRNA profiling and bioinformatics analyses reveal upregulated miRNAs in gastric cancer. Oncol Lett 18:1979–1988
Zha TZ, Hu BS, Yu HF, Tan YF, Zhang Y, Zhang K (2012) Overexpression of HOXA1 correlates with poor prognosis in patients with hepatocellular carcinoma. Tumour Biol 33:2125–2134
Zhang B, Pan X, Cobb GP, Anderson TA (2007) microRNAs as oncogenes and tumor suppressors. Dev Biol 302:1–12
Zhang CZ, Zhang JX, Zhang AL, Wang YY, Han L, You YP, Pu PY, Kang CS (2010a) PUMA is a novel target of miR-221/222 in human epithelial cancers. Int J Oncol 37:1621–1626
Zhang X, Gejman R, Mahta A, Zhong Y, Rice KA, Zhou YL, Cheunsuchon P, Louis DN, Klibanski A (2010b) Maternally expressed gene 3, an imprinted noncoding RNA gene, is associated with meningioma pathogenesis and progression. Cancer Res 70:2350–2358
Zhang P, Sun Y, Ma L (2015a) ZEB1: at the crossroads of epithelial-mesenchymal transition, metastasis and therapy resistance. Cell Cycle 14:481–487
Zhang HH, Tang JL, Li C, Kong JL, Wang JY, Wu YH, Xu EP, Lai MD (2015b) MiR-22 regulates 5-FU sensitivity by inhibiting autophagy and promoting apoptosis in colorectal cancer cells. Cancer Lett 356:781–790
Zhang D, Xiao YF, Zhang JW, Xie R, Hu CJ, Tang B, Wang SM, Wu YY, Hao NB, Yang SM (2015c) miR-1182 attenuates gastric cancer proliferation and metastasis by targeting the open reading frame of hTERT. Cancer Lett 360:151–159
Zhang J, Liu D, Feng Z, Mao J, Zhang C, Lu Y, Li J, Zhang Q, Li Q, Li L (2016a) MicroRNA-138 modulates metastasis and EMT in breast cancer cells by targeting vimentin. Biomed Pharmacother 77:135–141
Zhang H, Duan J, Qu Y, Deng T, Liu R, Zhang L, Bai M, Li J, Ning T, Ge S, Wang X, Wang Z, Fan Q, Li H, Ying G, Huang D, Ba Y (2016b) Onco-miR-24 regulates cell growth and apoptosis by targeting BCL2L11 in gastric cancer. Protein Cell 7:141–151
Zhang L, Shan X, Wang J, Zhu J, Huang Z, Zhang H, Zhou X, Cheng W, Shu Y, Zhu W, Liu P (2017a) A three-microRNA signature for lung squamous cell carcinoma diagnosis in Chinese male patients. Oncotarget 8:86897–86907
Zhang GX, Zhang W, Li BJ, Stringer-Reasor E, Chu CJ, Sun LY, Bae S, Chen DQ, Wei S, Jiao K, Yang WH, Cui RJ, Liu RH, Wang LZ (2017b) MicroRNA-200c and microRNA-141 are regulated by a FOXP3-KAT2B axis and associated with tumor metastasis in breast cancer. Breast Cancer Res 19:73
Zhang YL, Li XB, Hou YX, Fang NZ, You JC, Zhou QH (2017c) The lncRNA XIST exhibits oncogenic properties via regulation of miR-449a and Bcl-2 in human non-small cell lung cancer. Acta Pharmacol Sin 38:371–381
Zhang H, Zhu M, Shan X, Zhou X, Wang T, Zhang J, Tao J, Cheng W, Chen G, Li J, Liu P, Wang Q, Zhu W (2019a) A panel of seven-miRNA signature in plasma as potential biomarker for colorectal cancer diagnosis. Gene 687:246–254
Zhang XY, Zhou J, Xue DW, Li Z, Liu YL, Dong LM (2019b) MiR-515-5p acts as a tumor suppressor via targeting TRIP13 in prostate cancer. Int J Biol Macromol 129:227–232
Zhang Y, Zhang H, Zhang Z, Li S, Jiang W, Li X, Lv J (2019c) LncRNA MALAT1 cessation antagonizes hypoxia/reoxygenation injury in hepatocytes by inhibiting apoptosis and inflammation via the HMGB1-TLR4 axis. Mol Immunol 112:22–29
Zhang XH, Li BF, Ding J, Shi L, Ren HM, Liu K, Huang CC, Ma FX, Wu XY (2020) LncRNA DANCR-miR-758-3p-PAX6 molecular network regulates apoptosis and autophagy of breast cancer cells. Cancer Manage Res 12:4073–4084
Zhang S, Liu C, Zou X, Geng X, Zhou X, Fan X, Zhu D, Zhang H, Zhu W (2021) MicroRNA panel in serum reveals novel diagnostic biomarkers for prostate cancer. PeerJ 9:e11441
Zhao ZY, Liu JT, Wang CL, Wang Y, Jiang YG, Guo M (2014) MicroRNA-25 regulates small cell lung cancer cell development and cell cycle through cyclin E2. Int J Clin Exp Pathol 7:7726–7734
Zheng B, Liang L, Wang C, Huang S, Cao X, Zha R, Liu L, Jia D, Tian Q, Wu J, Ye Y, Wang Q, Long Z, Zhou Y, Du C, He X, Shi Y (2011) MicroRNA-148a suppresses tumor cell invasion and metastasis by downregulating ROCK1 in gastric cancer. Clin Cancer Res 17:7574–7583
Zheng L, Pu J, Qi T, Qi M, Li D, Xiang X, Huang K, Tong Q (2013) miRNA-145 targets v-ets erythroblastosis virus E26 oncogene homolog 1 to suppress the invasion, metastasis, and angiogenesis of gastric cancer cells. Mol Cancer Res 11:182–193
Zheng G, Xiong Y, Xu W, Wang Y, Chen F, Wang Z, Yan Z (2014) A two-microRNA signature as a potential biomarker for early gastric cancer. Oncol Lett 7:679–684
Zhou W, Shi G, Zhang Q, Wu Q, Li B, Zhang Z (2014) MicroRNA-20b promotes cell growth of breast cancer cells partly via targeting phosphatase and tensin homologue (PTEN). Cell Biosci 4:62
Zhou W, Ye XL, Xu J, Cao MG, Fang ZY, Li LY, Guan GH, Liu Q, Qian YH, Xie D (2017) The lncRNA H19 mediates breast cancer cell plasticity during EMT and MET plasticity by differentially sponging miR-200b/c and let-7b. Sci Signal 10:eaak9557
Zhou Y, Tian B, Tang JM, Wu J, Wang H, Wu ZN, Li X, Yang DS, Zhang BH, Xiao YH, Wang Y, Ma JL, Wang WX, Su M (2020a) SNHG7: a novel vital oncogenic lncRNA in human cancers. Biomed Pharmacother 124:109921
Zhou C, Yi C, Yi Y, Qin W, Yan Y, Dong X, Zhang X, Huang Y, Zhang R, Wei J, Ali DW, Michalak M, Chen XZ, Tang J (2020b) LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/beta-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 and miR-619-5p/ATG14 axes. Mol Cancer 19:118
Zhu SM, Si ML, Wu HL, Mo YY (2007) MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1). J Biol Chem 282:14328–14336
Zhu C, Ren C, Han J, Ding Y, Du J, Dai N, Dai J, Ma H, Hu Z, Shen H, Xu Y, Jin G (2014) A five-microRNA panel in plasma was identified as potential biomarker for early detection of gastric cancer. Br J Cancer 110:2291–2299
Zhu W, Zhou K, Zha Y, Chen D, He J, Ma H, Liu X, Le H, Zhang Y (2016) Diagnostic value of serum miR-182, miR-183, miR-210, and miR-126 levels in patients with early-stage non-small cell lung cancer. PloS One 11:e0153046
Zhu W, Huang Y, Pan Q, Xiang P, Xie N, Yu H (2017) MicroRNA-98 suppress warburg effect by targeting HK2 in colon cancer cells. Dig Dis Sci 62:660–668
Zhu YD, Shao SL, Pan HF, Cheng ZL, Rui X (2018) MicroRNA-136 inhibits prostate cancer cell proliferation and invasion by directly targeting mitogen-activated protein kinase kinase 4. Mol Med Rep 17:4803–4810
Zhu XL, Ren LF, Wang HP, Bai ZT, Zhang L, Meng WB, Zhu KX, Ding FH, Miao L, Yan J, Wang YP, Liu YQ, Zhou WC, Li X (2019) Plasma microRNAs as potential new biomarkers for early detection of early gastric cancer. World J Gastroenterol 25:1580–1591
Zhuang J, Shen L, Yang L, Huang X, Lu Q, Cui Y, Zheng X, Zhao X, Zhang D, Huang R, Guo H, Yan J (2017) TGFbeta1 promotes gemcitabine resistance through regulating the LncRNA-LET/NF90/miR-145 signaling axis in bladder cancer. Theranostics 7:3053–3067
Acknowledgements
This study was funded by Scientific Research Projects Coordination Unit of Istanbul University. Project number: 37223. We would like to thank Rachel Mollman, a native English-speaker, for language editing and proofreading.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2023 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Obut, O., Akbaba, P., Balcı, M.A., Bakır, Y., Eldem, V. (2023). MicroRNAs and Long Non-coding RNAs as Key Targets. In: Tuli, H.S., Yerer Aycan, M.B. (eds) Oncology: Genomics, Precision Medicine and Therapeutic Targets. Springer, Singapore. https://doi.org/10.1007/978-981-99-1529-3_3
Download citation
DOI: https://doi.org/10.1007/978-981-99-1529-3_3
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-99-1528-6
Online ISBN: 978-981-99-1529-3
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)