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Radiochemistry

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Imaging Infections

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Abstract

We have described the radiochemical methods to produce radiopharmaceuticals for SPECT and PET and also discussed the synthesis of several agents used for infection imaging. Translation of new agents to the clinic requires excellent preclinical validation, robust synthetic schemes, and compliance with manufacturing guidelines such as the GMP regulations enforced by the FDA. The specialized equipment (e.g., cyclotron) required to produce radiopharmaceuticals can be a challenge. However, central radiopharmacies, now a common phenomenon throughout the world, and distribution networks have partially solved this problem. However, the use of on-site generators, such as those used to produce 68Ga radiopharmaceuticals can greatly enhance the availably of radiopharmaceuticals, and kit formulations for 68Ga labeling are eagerly anticipated. Finally, the discovery of novel targets for pathogen-specific imaging as well as their specific ligands is very exciting, and robust radiolabeling techniques could expedite the development of future rapid and specific, whole-body detection and monitoring of infections such as tuberculosis (TB).

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Authors and Affiliations

  1. Department of Nuclear Medicine, Steve Biko Academic Hospital, University of Pretoria, Pretoria, South Africa

    Thomas Ebenhan

  2. Radiochemistry Group, Department of Applied Chemistry, South African Nuclear Energy Corporation SOC Limited, Pelindaba, South Africa

    Carl Wagener & Jan Rijn Zeevaart

  3. Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Lauren E. Bambarger & Alvin S. Kalinda

  4. Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Lauren E. Bambarger & Alvin S. Kalinda

Authors
  1. Thomas Ebenhan
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  2. Carl Wagener
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  3. Lauren E. Bambarger
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  4. Alvin S. Kalinda
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  5. Jan Rijn Zeevaart
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Corresponding author

Correspondence to Jan Rijn Zeevaart .

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Editors and Affiliations

  1. Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    Sanjay K. Jain

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Ebenhan, T., Wagener, C., Bambarger, L.E., Kalinda, A.S., Zeevaart, J.R. (2017). Radiochemistry. In: Jain, S. (eds) Imaging Infections . Springer, Cham. https://doi.org/10.1007/978-3-319-54592-9_4

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