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Preparation, quality control and stability of 99mTc-cefuroxime axetil

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Abstract

Cefuroxime axetil, a cephalosporin antibiotic used to treat bacterial infections, was investigated to label with 99mTc. Radiolabeling of cefuroxime axetil was carried out by using stannous chloride method. Effects of pH and stannous chloride amount on the radiolabeling yield were investigated. The radiochemical purity of 99mTc-cefuroxime axetil was determined by thin layer radio chromatography (TLRC), electrophoresis and high performance liquid chromatography. The maximum radiolabeling yield was 98±1%.

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Authors and Affiliations

  1. Department of Nuclear Applications, Institute of Nuclear Sciences, Ege University, 35100, Bornova, Izmir-Turkey

    F. Yurt Lambrecht, K. Durkan & P. Unak

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  1. F. Yurt Lambrecht
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  2. K. Durkan
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  3. P. Unak
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Correspondence to F. Yurt Lambrecht.

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Yurt Lambrecht, F., Durkan, K. & Unak, P. Preparation, quality control and stability of 99mTc-cefuroxime axetil. J Radioanal Nucl Chem 275, 161–164 (2008). https://doi.org/10.1007/s10967-007-6999-0

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  • DOI: https://doi.org/10.1007/s10967-007-6999-0

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