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Platelets in Neurological Disorders

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Platelets in Thrombotic and Non-Thrombotic Disorders

Abstract

Although blood platelets are primarily involved in hemostasis and thrombosis, it is well recognized that they are also implicated in a number of different physiological and pathological events, including inflammation, host defense, and tumor metastasis. In this chapter, we provide an update on the complex interplay between platelets and some complex neurological disorders, such as Alzheimer’s disease, depression, Parkinson’s disease, and autism. Platelets and neurons share several biological features, and platelets have been regarded as a suitable and easily accessible cellular model to investigate the molecular mechanisms underlying complex neuropathological disorders for many years. Moreover, alterations of platelet function and responsiveness in patients affected by neurological diseases have been widely documented and have fueled the search for platelet-specific tests for diagnostic and prognostic assays. Although this ambitious goal still remains to be pursued, a large number of studies performed on this topic over the last decades have significantly increased our general knowledge on the pathogenesis of complex neurological disorders and have also provided important insights into novel aspects of platelet biology.

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Authors and Affiliations

  1. Department of Biology and Biotechnology, University of Pavia, via Bassi 21, 27100, Pavia, Italy

    Ilaria Canobbio, Gianni F. Guidetti & Mauro Torti

Authors
  1. Ilaria Canobbio
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  2. Gianni F. Guidetti
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  3. Mauro Torti
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Correspondence to Mauro Torti .

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Editors and Affiliations

  1. Department of Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia , Perugia, Italy

    Paolo Gresele

  2. Houston Methodist Hospital , Houston, Texas, USA

    Neal S. Kleiman

  3. Bloodworks Northwest, University of Washington , Seattle, Washington, USA

    José A. Lopez

  4. Sackler Inst of Pulmonary Pharmacol, King’s College London, London, United Kingdom

    Clive P. Page

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Canobbio, I., Guidetti, G.F., Torti, M. (2017). Platelets in Neurological Disorders. In: Gresele, P., Kleiman, N., Lopez, J., Page, C. (eds) Platelets in Thrombotic and Non-Thrombotic Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-47462-5_35

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