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Platelet phospholipase A2 activity in patients with Alzheimer’s disease, vascular dementia and ischemic stroke

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Summary

Phospholipase A2 (E.C. 3.1.1.4, PLA2) plays an essential role in metabolism of membrane phospholipids, it is related to inflammatory reactions, secretion of amyloid precursor protein and activation of NMDA receptor after ischemia.

In the present study we investigated PLA2 activity in platelets from 37 Alzheimer’s disease (AD) patients, 32 vascular dementia (VaD) patients and 32 individuals with ischemic stroke as compared to 27 healthy elderly controls. PLA2 activity was determined using radiometric assay.

Mean platelet PLA2 activity was increased in individuals with Alzheimer’s disease (p < 0.001). In VaD group the enzyme activity was between the values in AD and controls, these differences being significant from both groups. In the group of patients with ischemic stroke mean PLA2 activity was higher either 48 h after the stroke or 7 days later (in both cases p < 0.001).

The results may be particularly interesting in light of the fact, that inhibitors of PLA2 activity are known.

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Authors and Affiliations

  1. Department of Late Age Neurology, Silesian Medical University, Katowice, Poland

    E. Krzystanek, G. Opala & J. Siuda

  2. Department of Psychiatry and Psychotherapy, Silesian Medical University, Katowice, Poland

    M. Krzystanek

  3. Department of Pharmacology, Silesian Medical University, Sosnowiec, Poland

    H. I. Trzeciak

  4. Department of Pharmacology, Silesian Medical University, Katowice, Poland

    A. Małecki

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  1. E. Krzystanek
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  2. M. Krzystanek
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  3. G. Opala
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  4. H. I. Trzeciak
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  5. J. Siuda
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  6. A. Małecki
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Krzystanek, E., Krzystanek, M., Opala, G. et al. Platelet phospholipase A2 activity in patients with Alzheimer’s disease, vascular dementia and ischemic stroke. J Neural Transm 114, 1033–1039 (2007). https://doi.org/10.1007/s00702-007-0669-9

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