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Cholinergic Effects of HI-6 in Soman Poisoning

  • Chapter
Dynamics of Cholinergic Function

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 30))

Abstract

During the past decade considerable advances have been made in the development of therapeutic antidotes against organophosphorus cholinesterase (ChE) inhibitors. Poisoning with most organophosphorus anticholinesterases (AntiChE) is treatable with a combination of an antimuscarinic compound, such as atropine sulfate (ATS), and an oxime, such as pralidoxime chloride (2-PAM) or toxogonin (18, 30, 34). The antidotal effects of oximes are generally thought to be due to their ability to reactivate the inhibited cholinesterase enzyme (10, 25, 26); however, a part of their beneficial effect has been ascribed to actions other than enzyme reactivation (4, 35, 41). Since most of the useful oximes are quaternary in structure and do not readily cross the blood brain barrier, the role played by the oximes in the central nervous system (CNS) is in some doubt (3, 25, 52). Although small quantities of these oximes do enter the central nervous system, the degree of reactivation of brain ChE is not great (11, 15).

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Author information

Authors and Affiliations

  1. Basic Pharmacology Branch, U.S. Army Medical Research Institute of Chemical Defense, USA

    T.-M. Shih & C. E. Whalley

  2. Toxicology Branch, Chemical Research and Development Center, Aberdeen Proving Ground, Maryland, USA

    J. J. Valdes

  3. Biomedical, Defense Research Establishment Suffield, Ralston, Alberta, Canada

    P. M. Lundy

  4. Chemistry Sections, Defense Research Establishment Suffield, Ralston, Alberta, Canada

    P. A. Lockwood

Authors
  1. T.-M. Shih
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  2. C. E. Whalley
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  3. J. J. Valdes
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  4. P. M. Lundy
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  5. P. A. Lockwood
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Editor information

Editors and Affiliations

  1. Loyola University Stritch School of Medicine, Chicago, Illinois, USA

    Israel Hanin Ph.D.

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© 1986 Plenum Press, New York

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Shih, TM., Whalley, C.E., Valdes, J.J., Lundy, P.M., Lockwood, P.A. (1986). Cholinergic Effects of HI-6 in Soman Poisoning. In: Hanin, I. (eds) Dynamics of Cholinergic Function. Advances in Behavioral Biology, vol 30. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5194-8_75

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  • DOI: https://doi.org/10.1007/978-1-4684-5194-8_75

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5196-2

  • Online ISBN: 978-1-4684-5194-8

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