Skip to main content
SpringerLink
Log in

Penetration of oximes across the blood-brain barrier. A histochemical study of the cerebral cholinesterases reactivation

  • Specialia
  • Published:
Experientia Aims and scope Submit manuscript

Summary

The comparison of the effects of 4 oximes upon the cerebral cholinesterases reactivation after intoxication with paraoxon shows that the best results are obtained with toxogonine and 1574 [(carbaldoxime-4 pyridinium)-1(methyl-1 imidazolium-3)-3 propane]. The reactivation power of this latter compound seems due to the ease with which it can pass through the blood-brain barrier.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. W.D. Erdmann, in: Medical protection against chemical warfare agents, chap. 3, p. 46. Ed. Sipri. Almqvist & Wiksell International, Stockholm 1976.

    Google Scholar 

  2. W.D. Erdmann, Arzneimittel-Forsch.15, 135 (1965).

    CAS  Google Scholar 

  3. F. Hobbiger and V. Vojvodić, Biochem. Pharmac.15, 1677 (1966).

    Article  CAS  Google Scholar 

  4. F. Hobbiger and V. Vojvodić, Biochem. Pharmac.16, 455 (1967).

    Article  CAS  Google Scholar 

  5. G.B. Koelle and J.S. Friedenwald, Proc. Soc. exp. Biol. Med.70, 617 (1949).

    Article  CAS  PubMed  Google Scholar 

  6. G.B. Koelle, J. comp. Neurol.100, 211 (1954).

    Article  CAS  PubMed  Google Scholar 

  7. K. Schoene, in: Medical protection against chemical warfare agents, chap. 8, p. 88. Ed. Sipri. Almqvist & Wiksell International, Stockholm 1976.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratoire de Neurocytologie, Université P. et M. Curie, 7, quai Saint-Bernard, F-75005, Paris, France

    I. S. De la Manche, D. E. Vergé, C. Bouchaud, H. Coq & H. Sentenac-Roumanou

Authors
  1. I. S. De la Manche
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. E. Vergé
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. C. Bouchaud
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. H. Coq
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. H. Sentenac-Roumanou
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Supported by grants from the Direction des Recherches et Etudes Techniques (D.R.E.T.) (No. 77–275).

Rights and permissions

Reprints and permissions

About this article

Cite this article

De la Manche, I.S., Vergé, D.E., Bouchaud, C. et al. Penetration of oximes across the blood-brain barrier. A histochemical study of the cerebral cholinesterases reactivation. Experientia 35, 531–532 (1979). https://doi.org/10.1007/BF01922752

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01922752

Keywords

Search

Navigation