Abstract
Therapeutic properties of various combinations of the bispyridinium salts HGG-12 and HGG-42 against soman and sarin poisoning were investigated in male beagles.
Best therapeutic efficiency was shown by HGG-42 in a dosage of 30 μMol/kg. Also good effects were produced by the combination of both oximes in a low dosage of 3 μMol/kg for each one.
In soman poisoning no significant reactivation of Cholinesterase in serum or erythrocytes was observed.
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References
Schenk, J., Löffler, W., Weger, N.: Therapeutic effects of HG-3, HS-6, benactyzine, and atropine in soman poisoning of dogs. Arch. Toxicol. 36, 71–81 (1976)
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Hauser, W., Weger, N. (2001). Therapeutic Effects of the Bis-Pyridinium Salts HGG-12, HGG-42, and Atropine, Benactyzine in Organophosphate Poisoning of Dogs. In: Chambers, P.L., Günzel, P. (eds) Mechanism of Toxic Action on Some Target Organs. Archives of Toxicology, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67265-1_44
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DOI: https://doi.org/10.1007/978-3-642-67265-1_44
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