Overview
- Editors:
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Jürg P. Seiler
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Interkantonale Kontrollstelle für Heilmittel, Switzerland
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Eugenio Vilanova
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Dept. of Neurochemistry Campus San Juan, University of Alicante, Alicante, Spain
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Table of contents (39 papers)
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In Vitro Cell models for investigating Molecular Mehanisms of Toxicity
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- José V. Castell, María José Gómez-Lechón, Xavier Ponsoda, Roque Bort
Pages 313-321
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Protein Targets of Neurotoxicity
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Front Matter
Pages 323-323
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- Hanna Tähti, Maria Engelke, Leila Vaalavirta
Pages 337-345
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- M. A. Sogorb, S. Bas, L. M. Gutiérrez, E. Vilanova, S. Viniegra
Pages 347-355
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Carcinogenesis Mechanisms in Transgenic Mouse Models
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Front Matter
Pages 357-357
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- Snorri S. Thorgeirsson, Eric Santoni-Rugiu, Cindy D. Davis, Elizabeth G. Snyderwine
Pages 359-366
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- D. Schrenk, M. Müller, G. Merlino, S. S. Thorgeirsson
Pages 367-375
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- Ilona Kryspin Sørensen, Eva Kristiansen, Alicja Mortensen, Coen van Kreijl, Richard H. Adamson, Snorri S. Thorgeirsson
Pages 377-386
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Algal Toxins and Human Health
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Front Matter
Pages 387-387
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- G. A. Codd, C. J. Ward, S. G. Bell
Pages 399-410
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The Young Scientist Poster Award
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Front Matter
Pages 411-411
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- Michael Lush, David Read, Paul Glynn
Pages 413-413
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Back Matter
Pages 415-420
About this book
Ultraviolet radiation, a component of sunlight, has been recognized by photobiologists, dermatologists, and oculists as a potential hazard for human health because of its genotoxic, carcinogenic and immunotoxic properties. Its effects on human health include the induction of skin cancers, ocular damage and impairment of immunity to certain infections. A few decennia ago it was demonstrated that UV photons can affect the activity of the immune system through interactions with the skin. This means that UV not only changes normal cells into cancer cells but also permits the outgrowth of the UV -transformed cells by depressing the immune system. An intriguing question is what interactions between UV radiation and the skin initiates alterations in immune function in the exposed skin and systemically, i. e. in other places than the exposed skin. During the last 20 years many studies have been performed in order to investigate the immunosuppressive activities of UVB in laboratory animals and in human volunteers. In particular effects of UVB radiation on resistance to tumours and skin associated infections have been examined. In addition, effects of UVB radiation on immune parameters such as contact hypersensitivity and delayed-type hypersensitivity (both type IV hypersensitivity reactions), mixed lymphocyte reactions, mixed skin lymphocyte reactions, antigen presentation and numbers and function of Langerhans cells have been studied intensively. The antigenicity of murine tumours which are caused by UVB radiation was one of the first items to be investigated (Kripke, 1974).
Editors and Affiliations
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Interkantonale Kontrollstelle für Heilmittel, Switzerland
Jürg P. Seiler
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Dept. of Neurochemistry Campus San Juan, University of Alicante, Alicante, Spain
Eugenio Vilanova