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Hepatic Tumor Induction in c- Myc mono-transgenic and TGF- α/c-Myc double-transgenic Mice

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Book cover Applied Toxicology: Approaches Through Basic Science

Part of the book series: Archives of Toxicology ((TOXICOLOGY,volume 19))

Summary

Double transgenic mice bearing fusion genes consisting of mouse albumin enhancer/promoter-mouse c-myc cDNA and mouse metallothionein 1 promoter-human TGF-α cDNA were generated to investigate the interaction of these genes in hepatic oncogenesis and to provide a general paradigm for characterizing both the interaction of nuclear oncogenes and growth factors in tumorigenesis as well as to produce an experimental model to test how environmental chemicals might interact with these genes during the neoplastic process. Coexpression of c-myc and TGF-α as transgenes in the mouse liver resulted in a tremendous acceleration of neoplastic development in this organ as compared to expression of either of these transgenes alone. The two distinct cellular reactions that occurred in the liver of the double transgenic mice prior to the appearance of liver tumors were dysplastic and apoptotic changes in the existing hepatocytes followed by emergence of multiple focal lesions composed of both hyperplastic and dysplastic cell populations.

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Authors and Affiliations

  1. Laboratory of Experimental Carcinogenesis, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

    Snorri S. Thorgeirsson, Eric Santoni-Rugiu, Cindy D. Davis & Elizabeth G. Snyderwine

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  1. Snorri S. Thorgeirsson
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  2. Eric Santoni-Rugiu
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  3. Cindy D. Davis
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  4. Elizabeth G. Snyderwine
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Editor information

Editors and Affiliations

  1. Interkantonale Kontrollstelle für Heilmittel, Erlachstrasse 8, CH-3000 Bern 9, Switzerland

    Jürg P. Seiler

  2. Dept. of Neurochemistry Campus San Juan, University of Alicante, Aptdo. 374, E-03080, Alicante, Spain

    Eugenio Vilanova

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© 1997 Springer-Verlag Berlin Heidelberg

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Thorgeirsson, S.S., Santoni-Rugiu, E., Davis, C.D., Snyderwine, E.G. (1997). Hepatic Tumor Induction in c- Myc mono-transgenic and TGF- α/c-Myc double-transgenic Mice. In: Seiler, J.P., Vilanova, E. (eds) Applied Toxicology: Approaches Through Basic Science. Archives of Toxicology, vol 19. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60682-3_34

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  • DOI: https://doi.org/10.1007/978-3-642-60682-3_34

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64505-1

  • Online ISBN: 978-3-642-60682-3

  • eBook Packages: Springer Book Archive

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