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  • Book
  • Open Access
  • © 2017

Genome Editing in Neurosciences

Editors:

  1. Rudolf Jaenisch

    1. Whitehead Institute and Department of Biology, Massachusetts Institute of Technology, Cambridge, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Feng Zhang

    1. Department of Brain and Cognitive Science, Broad Institute of MIT and Harvard, Cambridge, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  3. Fred Gage

    1. Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Highlights how genome editing is enabling breakthroughs in how we study the brain

  • Identifies a powerful method to understand and treat central nervous system disorders

  • Reveals system-level insight into how the nervous system develops and functions

  • Includes supplementary material: sn.pub/extras

Part of the book series: Research and Perspectives in Neurosciences (NEUROSCIENCE)

Sections

Softcover Book USD 59.99
Price excludes VAT (USA)
Hardcover Book USD 59.99
Price excludes VAT (USA)
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Table of contents (10 chapters)

  1. Front Matter

    Pages i-xi
    PDF

  2. In Vitro Modeling of Complex Neurological Diseases

    • Frank Soldner, Rudolf Jaenisch
    Pages 1-19Open Access

  4. Genome-Wide Genetic Screening in the Mammalian CNS

    • Mary H. Wertz, Myriam Heiman
    Pages 31-39Open Access

  5. CRISPR/Cas9-Mediated Knockin and Knockout in Zebrafish

    • Shahad Albadri, Flavia De Santis, Vincenzo Di Donato, Filippo Del Bene
    Pages 41-49Open Access

  6. Dissecting the Role of Synaptic Proteins with CRISPR

    • Salvatore Incontro, Cedric S. Asensio, Roger A. Nicoll
    Pages 51-62Open Access

  8. Neuroscience Research Using Non-human Primate Models and Genome Editing

    • Noriyuki Kishi, Hideyuki Okano
    Pages 73-81Open Access

  10. Using Genome Engineering to Understand Huntington’s Disease

    • Barbara Bailus, Ningzhe Zhang, Lisa M. Ellerby
    Pages 87-101Open Access

  11. Therapeutic Gene Editing in Muscles and Muscle Stem Cells

    • Mohammadsharif Tabebordbar, Jason Cheng, Amy J. Wagers
    Pages 103-123Open Access
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About this book

This book is open access under a CC BY 4.0 license.

CRISPR-Cas9 is a rapid, efficient, versatile and relatively cheap method for dissecting the molecular pathways that are the basis of life, as well as for investigating and potentially rectifying faults in these pathways that result in disease.

This book reviews how CRISPR-Cas9 and other genome editing techniques are advancing our understanding of development and function in the nervous system, uncovering the molecular causes of neurological disorders and providing tools for gene therapy.

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Keywords

  • CRISPR-Cas9
  • genetic engineering
  • recombinant-DNA methods
  • double-strand breaks
  • Ciona intestinalis
  • isogenic IPSCs
  • Parkinson's disease
  • Huntington's disease
  • Rett syndrome
  • Duchenne muscular dystrophy
  • Open Access
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Editors and Affiliations

  • Whitehead Institute and Department of Biology, Massachusetts Institute of Technology, Cambridge, USA

    Rudolf Jaenisch

  • Department of Brain and Cognitive Science, Broad Institute of MIT and Harvard, Cambridge, USA

    Feng Zhang

  • Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, USA

    Fred Gage

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About the editors

Rudolf Jaenisch, MIT Cambridge, USA
Feng Zhang, MIT Cambridge, USA
Fred Gage, Salk Institute for Biological Studies, La Jolla, CA, USA
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Bibliographic Information

  • Book Title: Genome Editing in Neurosciences

  • Editors: Rudolf Jaenisch, Feng Zhang, Fred Gage

  • Series Title: Research and Perspectives in Neurosciences

  • DOI: https://doi.org/10.1007/978-3-319-60192-2

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s) 2017

  • License: CC BY

  • Hardcover ISBN: 978-3-319-60191-5Published: 22 September 2017

  • Softcover ISBN: 978-3-319-86801-1Published: 11 August 2018

  • eBook ISBN: 978-3-319-60192-2Published: 14 September 2017

  • Series ISSN: 0945-6082

  • Series E-ISSN: 2196-3096

  • Edition Number: 1

  • Number of Pages: XI, 123

  • Number of Illustrations: 16 illustrations in colour

  • Topics: Medical Genetics, Neuroscience, Biotechnology

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Softcover Book USD 59.99
Price excludes VAT (USA)
Hardcover Book USD 59.99
Price excludes VAT (USA)
Learn about institutional subscriptions