Table of contents

  1. Front Matter
    Pages i-xi
  2. Frank Soldner, Rudolf Jaenisch
    Pages 1-19 Open Access
  3. Mary H. Wertz, Myriam Heiman
    Pages 31-39 Open Access
  4. Shahad Albadri, Flavia De Santis, Vincenzo Di Donato, Filippo Del Bene
    Pages 41-49 Open Access
  5. Salvatore Incontro, Cedric S. Asensio, Roger A. Nicoll
    Pages 51-62 Open Access
  6. Noriyuki Kishi, Hideyuki Okano
    Pages 73-81 Open Access
  7. Barbara Bailus, Ningzhe Zhang, Lisa M. Ellerby
    Pages 87-101 Open Access
  8. Mohammadsharif Tabebordbar, Jason Cheng, Amy J. Wagers
    Pages 103-123 Open Access

About this book


This book is open access under a CC BY 4.0 license.

Innovations in molecular biology are allowing neuroscientists to study the brain with unprecedented resolution, from the level of single molecules to integrated gene circuits. Chief among these innovations is the CRISPR-Cas genome editing technology, which has the precision and scalability to tackle the complexity of the brain. This Colloque Médecine et Recherche has brought together experts from around the world that are applying genome editing to address important challenges in neuroscience, including basic biology in model organisms that has the power to reveal systems-level insight into how the nervous system develops and functions as well as research focused on understanding and treating human neurological disorders.


CRISPR-Cas9 genetic engineering recombinant-DNA methods double-strand breaks Ciona intestinalis isogenic IPSCs Parkinson's disease Huntington's disease Rett syndrome Duchenne muscular dystrophy Open Access

Editors and affiliations

  • Rudolf Jaenisch
    • 1
  • Feng Zhang
    • 2
  • Fred Gage
    • 3
  1. 1.Whitehead Institute and Department of BiologyMassachusetts Institute of TechnologyCambridgeUSA
  2. 2.Department of Brain and Cognitive ScienceBroad Institute of MIT and HarvardCambridgeUSA
  3. 3.Laboratory of GeneticsSalk Institute for Biological StudiesLa JollaUSA

Bibliographic information