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Epigenomics

  • Anne C. Ferguson-Smith
  • John M. Greally
  • Robert A. Martienssen

Table of contents

  1. Front Matter
    Pages I-XIV
  2. Epigenomic Technologies and Analytical Approaches

    1. Front Matter
      Pages 1-1
    2. A.B. Brinkman, H.G. Stunnenberg
      Pages 3-18
    3. Alexander Meissner, Bradley E. Bernstein
      Pages 19-35
    4. Suk-Young Yoo, R.W. Doerge
      Pages 37-53
    5. Paul Flicek, Ewan Birney
      Pages 55-66
  3. Roles of DNA, RNA and Chromatin in Epigenomics

    1. Front Matter
      Pages 67-67
    2. Xiaodong Cheng, Robert M. Blumenthal
      Pages 85-100
    3. Steven Henikoff
      Pages 101-118
    4. Jay B. Hollick, Nathan Springer
      Pages 119-147
    5. Ian R. Henderson
      Pages 163-175
    6. Shinwa Shibata, Jeannie T. Lee
      Pages 187-214
  4. Epigenetic Control of Developmental Processes

    1. Front Matter
      Pages 215-215
    2. Yuri B. Schwartz, Vincenzo Pirrotta
      Pages 217-233
    3. Kirsten R. McEwen, Anne C. Ferguson-Smith
      Pages 235-258
    4. Gabriella Ficz, Cassandra R. Farthing, Wolf Reik
      Pages 259-282
    5. Ann Dean, Steven Fiering
      Pages 283-299
  5. The Epigenome in Health and Disease

    1. Front Matter
      Pages 319-319
    2. M.R. Rountree, E.U. Selker
      Pages 321-341
    3. Esteban Ballestar, Manel Esteller
      Pages 369-384
    4. Christine Ladd-Acosta, Andrew P. Feinberg
      Pages 385-395
    5. Mark R. Doyle, Richard M. Amasino
      Pages 397-410
    6. Jonathan Mill, Arturas Petronis
      Pages 411-434
  6. Back Matter
    Pages 435-438

About this book

Introduction

Epigenetic modifications act on DNA and its packaging proteins, the histones, to regulate genome function. Manifest as the heritable methylation of DNA and as post-translational histone modifications, these molecular flags influence the architecture and integrity of the chromosome, the accessibility of DNA to gene regulatory components and the ability of chromatin to interact within nuclear complexes. While a multicellular individual has only one genome, it has multiple epigenomes reflecting the diversity of cell types and their properties at different times of life; in health and in disease. Relationships are emerging between the underlying DNA sequence and dynamic epigenetic states and their consequences,such as the role of RNA interference and non-coding RNA. These integrated approaches go hand-in-hand with studies describing the genomic locations of epigenetic modifications in different cell types at different times.

The excitement and curiosity surrounding epigenomics is driven by a growing community of researchers in a burgeoning field and the development of new technologies built on the backbone of genome sequencing projects. Research has shown that the adaptability and vulnerability of epigenetic states has profound effects on natural variation, the response of the genome to its environment and on health and disease.

The aim of this volume is not to describe epigenomes, but rather to explore how understanding epigenomes tells us more about how biological systems work and the challenges and approaches taken to accomplish this. These contributions have attempted to integrate epigenomics into our understanding of genomes in wider context, and to communicate some of the wonders of epigenetics illustrated through examples across the biological spectrum.

Keywords

Chromosom DNA Epigenetic modifications genes genetics translation

Editors and affiliations

  • Anne C. Ferguson-Smith
    • 1
  • John M. Greally
    • 2
  • Robert A. Martienssen
    • 3
  1. 1.Department of Physiology Development and NeuroscienceUniversity of CambridgeUK
  2. 2.Albert Einstein College of MedicineBronx NY 10461USA
  3. 3.Cold Spring Harbor LaboratoryCold Spring HarborUSA

Bibliographic information