Abstract
The eukaryotic genome is packaged into nucleosomes, which form the basal unit of chromatin, the physiological form of DNA within the nucleus. Apart from its function in compacting the immense nuclear DNA molecules, chromatin also serves as a platform onto which multiple signalling pathways converge to cooperate in determining the expression status of mRNAs and other (non-coding) RNA molecules. Epigenetic profile analysis aims to determine what changes on the nucleosomes cooperate to establish and maintain DNA sequence-independent heritable traits such as those determining cell identity.
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Brinkman, A., Stunnenberg, H. (2009). Strategies for Epigenome Analysis. In: Ferguson-Smith, A.C., Greally, J.M., Martienssen, R.A. (eds) Epigenomics. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-9187-2_1
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DOI: https://doi.org/10.1007/978-1-4020-9187-2_1
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