Epigenomics pp 187-214 | Cite as

MacroRNAs in the Epigenetic Control of X-Chromosome Inactivation

  • Shinwa Shibata
  • Jeannie T. Lee

Abstract

Sex chromosome dosage compensation in mammals is achieved by {X-chromosome} inactivation (XCI) in the female sex. In the mammalian female cells, only one X-chromosome is transcribed, while the other is permanently silenced. As a quintessential example of epigenetic control, XCI has been the subject of intense investigation. This process is regulated by complex interplay between multiple cis-acting non-coding genes, including Xist, Tsix, Xite, and DXPas34. All make large noncoding RNAs – so-called ‘macroRNAs’ – and together orchestrate the cascade of events involved in X-chromosome counting, choice, and the initiation of silencing. In addition to their well-establishedroles in cis, some of the non-coding loci also play roles in trans. This chapter will first summarize the current state of knowledge and focus on recent developments.

Keywords

Xist Tsix Xite DXPas34 X-chromosome inactivation {noncoding} RNA antisense genes heterochromatin CpG-methylation histone modification chromatin structure 

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Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  • Shinwa Shibata
    • 1
  • Jeannie T. Lee
    • 1
  1. 1.Department of Stem Cell Biology Graduate School of Medical SciencesKanazawa UniversityKanazawaJapan

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